Top 10 Companies in the (S)-Glycidylbutyrate (CAS 65031-96-1) Market (2026): Market Leaders Driving Global Chiral Chemistry

MARKET INSIGHTS

Global (S)-Glycidylbutyrate (CAS 65031-96-1) market size was valued at USD 28.4 million in 2025. The market is projected to grow from USD 30.1 million in 2026 to USD 52.7 million by 2034, exhibiting a CAGR of 6.4% during the forecast period.

(S)-Glycidylbutyrate is a chiral epoxide ester compound recognized for its high optical purity and reactivity, making it a valuable building block in asymmetric synthesis and pharmaceutical manufacturing. The compound serves as a key intermediate in the production of optically active fine chemicals, including beta‑blockers, antifungal agents, and other enantioselective drug substances, where precise stereochemistry is critical to therapeutic efficacy.

The market is witnessing steady growth driven by rising demand for enantiopure intermediates within the pharmaceutical and agrochemical industries, alongside growing adoption of green chemistry principles that favor chiral catalysis routes. Furthermore, expanding research activities in asymmetric synthesis and the increasing pipeline of stereospecific drug candidates are reinforcing demand. Key suppliers of chiral specialty chemicals, including Sigma‑Aldrich (Merck KGaA), TCI Chemicals, and Alfa Aesar, maintain active commercial offerings of this compound to support global research and industrial applications.

(S)-Glycidylbutyrate (CAS 65031-96-1) Market – View in Detailed Research Report

Top 10 Companies in the (S)-Glycidylbutyrate (CAS 65031-96-1) Market

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1️⃣ TCI Chemicals

Headquarters: Tokyo, Japan
Key Offering: High‑purity (S)-Glycidylbutyrate (99% ee and 98% ee), research‑grade, bulk supplies

TCI has a long history in fine chemicals, delivering a range of chiral building blocks that meet the stringent quality demands of pharmaceutical and agrochemical synthesis. Its (S)-Glycidylbutyrate portfolio is available in multiple purity grades, enabling seamless integration into complex synthetic routes.

Sustainability Initiatives:

• Investment in green chemistry laboratories and renewable feedstock utilization
• Optimized process flows to reduce solvent consumption
• Compliance with international environmental standards

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2️⃣ Sigma‑Aldrich (Merck KGaA)

Headquarters: Darmstadt, Germany
Key Offering: Comprehensive catalog, GMP‑grade (S)-Glycidylbutyrate, custom synthesis

Sigma‑Aldrich serves as a global distributor, providing high‑purity chiral intermediates with robust analytical support. The company’s rigorous quality control framework ensures consistent enantiomeric excess and traceability.

Sustainability Initiatives:

• Waste‑minimizing manufacturing processes
• Use of renewable energy sources in production facilities
• Lifecycle assessment for key products

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3️⃣ Thermo Fisher Scientific (Alfa Aesar)

Headquarters: Waltham, MA, USA
Key Offering: Research‑grade and GMP‑grade (S)-Glycidylbutyrate, rapid shipping

Thermo Fisher delivers a robust supply chain with dedicated quality control, supporting pharmaceutical R&D and early‑stage discovery. The company’s integrated analytical services provide comprehensive purity verification.

Sustainability Initiatives:

• Sustainable packaging options
• Carbon‑neutral logistics for high‑value products
• Continuous process improvement to reduce waste

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4️⃣ Capot Chemical

Headquarters: Shanghai, China
Key Offering: Competitive pricing, flexible order quantities, 98% ee product

Capot has expanded its chiral portfolio to provide cost‑effective solutions for early‑stage research and pilot‑scale projects. The company emphasizes rapid turnaround and reliable quality.

Sustainability Initiatives:

• Local manufacturing reduces shipping footprint
• Energy‑efficient production lines
• Waste minimization through process optimization

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5️⃣ Leap Chem

Headquarters: Shenzhen, China
Key Offering: High‑purity (S)-Glycidylbutyrate (99% ee), custom packaging

Leap Chem serves both domestic and export markets, focusing on quality and rapid delivery. The company supports advanced research with high‑purity reagents.

Sustainability Initiatives:

• Renewable energy use in production facilities
• Eco‑friendly solvent selection
• Recyclable packaging materials

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6️⃣ Hairui Chemical

Headquarters: Guangzhou, China
Key Offering: Research‑grade, 97% ee, affordable pricing

Hairui provides a wide range of chiral intermediates, supporting academic research with accessible pricing and reliable quality.

Sustainability Initiatives:

• Waste reduction programs
• Use of recyclable containers
• Energy‑efficient production processes

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7️⃣ Combi‑Blocks

Headquarters: Waltham, MA, USA
Key Offering: Custom chiral synthesis, (S)-Glycidylbutyrate (99% ee), rapid turnaround

Combi‑Blocks specializes in tailored chiral solutions, offering rapid custom synthesis for pharmaceutical and biotech clients. The company’s process optimization reduces solvent use and improves atom economy.

Sustainability Initiatives:

• Process optimization to lower solvent consumption
• Use of green catalysts where feasible
• Support for carbon‑neutral shipping options

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8️⃣ Fluorochem

Headquarters: London, UK
Key Offering: High‑purity (S)-Glycidylbutyrate (99% ee), analytical certificates

Fluorochem supplies a niche range of high‑purity chiral reagents, catering to advanced research laboratories. The company provides detailed analytical data to support regulatory submissions.

Sustainability Initiatives:

• Green solvent selection
• Life‑cycle assessment for key products
• Recyclable packaging solutions

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9️⃣ Alfa Aesar

Headquarters: Albany, NY, USA
Key Offering: Research‑grade (S)-Glycidylbutyrate (98% ee), affordable

Alfa Aesar offers an extensive catalog of fine chemicals, with a focus on accessibility for academic users. The company emphasizes consistent quality and transparent pricing.

Sustainability Initiatives:

• Recyclable packaging materials
• Responsible sourcing of raw materials
• Energy‑efficient manufacturing practices

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🔟 Koch Chemical

Headquarters: Houston, TX, USA
Key Offering: High‑purity (S)-Glycidylbutyrate (99% ee), bulk supply, GMP compliance

Koch Chemical serves the pharmaceutical and specialty chemical markets with consistent quality and reliable delivery. The company invests in energy‑efficient production and supports carbon‑neutral logistics.

Sustainability Initiatives:

• Energy‑efficient production lines
• Carbon‑neutral shipping options
• Continuous improvement of solvent recovery systems

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Outlook

From 2026 to 2034, the (S)-Glycidylbutyrate market will continue to expand, reaching USD 52.7 million by 2034. The steady increase reflects the growing emphasis on enantiopure intermediates in pharmaceutical development and the expanding pipeline of stereospecific drug candidates. Regulatory frameworks across major markets require rigorous chiral characterization, reinforcing the need for high‑purity building blocks. The rising trend toward outsourcing synthesis to contract development and manufacturing organizations (CDMOs) further supports incremental volume growth, especially from suppliers that can consistently deliver >98% ee.

Future Trends

Emerging drivers in the market include the broader adoption of enzymatic and biocatalytic routes, which reduce reliance on heavy‑metal catalysts and improve atom economy. Artificial intelligence–driven retrosynthesis platforms are accelerating the design of chiral routes, enabling faster route optimization and cost reduction. Digital supply‑chain solutions are enhancing traceability and quality assurance for chiral intermediates, while sustainability metrics become key differentiators for buyers. Geographical expansion, particularly in the Asia‑Pacific region, will create new demand corridors as local pharmaceutical sectors mature and invest in advanced synthesis capabilities.