The Global Histidine Market was valued at USD 245 Million in 2025 and is projected to reach USD 349 Million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 6.3% during the forecast period (2025–2032). This growth is being driven by increasing demand from pharmaceutical formulations, protein-fortified food supplements, and the expanding animal feed industry in emerging economies.

As the global health and nutrition sector focuses on essential amino acids for human and animal well-being, the spotlight is on the key producers who are driving production innovation, quality standards, and supply chain efficiency. In this blog, we profile the Top 10 Companies in the Histidine Industry—a mix of established biotechnology giants, specialized manufacturers, and emerging players shaping the future of amino acid supply.

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🔟 1. Kyowa Hakko Bio

Headquarters: Tokyo, Japan
Key Offering: Pharmaceutical Grade L-Histidine, Feed Grade L-Histidine

Kyowa Hakko Bio is a global leader in amino acid production, with L-Histidine being one of its flagship products. The company leverages advanced microbial fermentation technology to produce high-purity histidine that meets stringent international pharmacopeia standards. Their products are integral to intravenous solutions, nutraceuticals, and premium animal feed formulations worldwide.

Innovation Initiatives:

• Pioneering high-yield fermentation strains for cost-effective production

• Strategic partnerships with global pharmaceutical companies

• Continuous R&D investment exceeding 5% of annual revenue

Download FREE Sample Report: Histidine Market – View in Detailed Research Report

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9️⃣ 2. Ajinomoto Co., Inc.

Headquarters: Tokyo, Japan
Key Offering: AJINOMOTO® L-Histidine, Specialty Amino Acid Blends

Ajinomoto is one of the world’s largest amino acid manufacturers, with a comprehensive portfolio that includes high-quality L-Histidine. The company’s global distribution network and vertically integrated production capabilities ensure a stable supply for diverse applications from clinical nutrition to industrial uses.

Innovation Initiatives:

• Development of proprietary purification technologies

• Expansion into value-added amino acid formulations

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8️⃣ 3. Evonik Industries AG

Headquarters: Essen, Germany
Key Offering: Pharmaceutical Grade Histidine, Feed Additives

Evonik’s Health & Nutrition division is a significant player in the specialty amino acids market. The company’s focus on sustainable production and rigorous quality control makes it a preferred supplier for European pharmaceutical and nutraceutical companies requiring certified histidine.

Innovation Initiatives:

• Sustainable bioprocess development for amino acid production

• Digitalization of supply chain management

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7️⃣ 4. Shine Star (Hubei) Biological Engineering Co., Ltd.

Headquarters: Hubei, China
Key Offering: Food Grade L-Histidine, Industrial Grade Histidine

As one of China’s leading amino acid producers, Shine Star Biological Engineering has significantly expanded its histidine production capacity in recent years. The company competes effectively in price-sensitive markets while gradually improving product quality to meet international standards.

Innovation Initiatives:

• Capacity expansion projects targeting export markets

• Investment in quality improvement initiatives

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6️⃣ 5. KingYork Group

Headquarters: Shijiazhuang, China
Key Offering: Pharmaceutical Intermediates, L-Histidine HCL

KingYork Group has established itself as a reliable manufacturer of amino acids and pharmaceutical intermediates. The company’s strength lies in its cost-competitive production methods and flexibility in serving both domestic Chinese and international markets.

Innovation Initiatives:

• Development of customized amino acid formulations

• Expansion into pharmaceutical application development

Download FREE Sample Report: Histidine Market – View in Detailed Research Report

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5️⃣ 6. Huaheng Biological Technology Co., Ltd.

Headquarters: Shandong, China
Key Offering: Bio-based L-Histidine, Amino Acid Supplements

Huaheng Biological specializes in fermentation-derived amino acids, with growing capabilities in histidine production. The company focuses on serving the rapidly expanding Asian market for dietary supplements and animal nutrition products.

Innovation Initiatives:

• Optimization of fermentation processes for higher yields

• Partnerships with domestic supplement manufacturers

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4️⃣ 7. Wuhan Microsen Technology Co., Ltd.

Headquarters: Wuhan, China
Key Offering: High-Purity L-Histidine, Custom Amino Acid Solutions

Wuhan Microsen Technology has emerged as a specialized producer of fine chemicals and amino acids. The company’s technical expertise in purification processes positions it well for serving quality-conscious customers in pharmaceutical applications.

Innovation Initiatives:

• Focus on high-purity specialty amino acids

• Development of application-specific histidine formulations

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3️⃣ 8. Shaoxing Yamei Biotechnology Co., Ltd.

Headquarters: Zhejiang, China
Key Offering: Food Grade Amino Acids, L-Histidine for Nutrition

Shaoxing Yamei Biotechnology has built a reputation for consistent quality in amino acid production. The company serves primarily the domestic Chinese market but has increasing visibility in international trade, particularly in Southeast Asia.

Innovation Initiatives:

• Process optimization for cost reduction

• Expansion into adjacent amino acid markets

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2️⃣ 9. Bafeng Pharmaceutical & Chemical Co., Ltd.

Headquarters: Zhejiang, China
Key Offering: Pharmaceutical Intermediates, Amino Acid Salts

Bafeng Pharmaceutical leverages its chemical synthesis expertise to produce histidine and related compounds. The company’s integrated manufacturing approach provides flexibility in serving diverse customer requirements across different purity grades.

Innovation Initiatives:

• Diversification into pharmaceutical-grade amino acids

• Quality system upgrades for regulatory compliance

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1️⃣ 10. Shanghai Freemen Technology Co., Ltd.

Headquarters: Shanghai, China
Key Offering: L-Histidine, Amino Acid Research Chemicals

Shanghai Freemen Technology operates as both a manufacturer and distributor of amino acids, including histidine. The company’s strategic location and logistics capabilities make it an important player in the supply chain for research institutions and smaller-scale industrial users.

Innovation Initiatives:

• Development of research-grade amino acid products

• Enhanced supply chain management for international customers

Get Full Report Here: Histidine Market – View in Detailed Research Report

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🌍 Outlook: The Future of Histidine Is Precision and Personalization

The histidine market is undergoing a significant transformation. While traditional production methods still dominate, the industry is increasingly focusing on high-purity applications, sustainable manufacturing, and customized formulations for specific health and nutritional needs.

📈 Key Trends Shaping the Market:

• Growing demand for pharmaceutical-grade histidine in biologic drugs and infusion therapies

• Increased incorporation of histidine in sports nutrition and clinical nutrition products

• Technological advancement in fermentation efficiency and purification processes

• Strategic partnerships between amino acid producers and end-user industries

Get Full Report Here: Histidine Market – View in Detailed Research Report

The companies listed above are not only supplying essential nutrients—they’re advancing the science of personalized nutrition and therapeutic applications.