The Global Pharma Grade Lentinan Market was valued at US$ 45.2 Million in 2022 and is projected to reach US$ 92.7 Million by 2029, growing at a Compound Annual Growth Rate (CAGR) of 10.8% during the forecast period (2023–2029). This growth is being driven by rising demand for natural immunomodulators in cancer therapies, expanding applications in health supplements, and increasing regulatory approvals for beta-glucan based pharmaceuticals across oncology and wellness sectors.

As the pharmaceutical industry shifts toward natural and biologically derived compounds for enhanced patient outcomes and fewer side effects, the focus turns to key producers of high-purity Lentinan. Derived from the shiitake mushroom (Lentinus edodes), this beta-glucan polysaccharide has gained prominence for its potential in boosting immune responses, particularly in cancer treatment. In this blog, we profile the Top 10 Companies in the Pharma Grade Lentinan Market—a blend of biotechnology firms, natural product specialists, and pharmaceutical innovators shaping the future of immunotherapy and functional health products.

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🔟 1. Ajinomoto Co., Inc.

Headquarters: Tokyo, Japan
Key Offering: High-purity Lentinan extracts (above 98% purity), pharmaceutical-grade beta-glucans for oncology

Ajinomoto stands as a global leader in amino acids and bioactive compounds, with a strong foothold in the Lentinan market through its advanced fermentation technologies. The company’s products are widely used in Japanese pharmaceuticals, where Lentinan was first approved for gastric cancer adjunct therapy in the 1980s. Ajinomoto supplies to major hospitals and research institutions, emphasizing consistent quality and bioavailability in their formulations.

Research and Development Initiatives:

• Ongoing clinical trials for Lentinan in combination with chemotherapy
• Investments in sustainable mushroom cultivation to ensure raw material purity
• Commitment to expanding Lentinan applications in global immunotherapy markets

Download FREE Sample Report: Pharma Grade Lentinan Market – View in Detailed Research Report

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9️⃣ 2. Nammex Specialty Mushrooms

Headquarters: Langley, British Columbia, Canada
Key Offering: Organic pharma-grade Lentinan (purity above 98%), beta-glucan isolates for supplements and drugs

Nammex specializes in organic mushroom extracts and has built a reputation for high-quality Lentinan production using controlled cultivation methods. Operating in over 20 countries, the company supplies pharmaceutical partners focused on immune health, with products tested for potency and free from contaminants. Their emphasis on traceability makes them a preferred source for clinical-grade materials.

Research and Development Initiatives:

• Collaborations with universities on Lentinan’s anti-tumor properties
• Development of standardized extraction processes for consistent dosing

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8️⃣ 3. Xi’an Yuansun Biological Technology Co., Ltd.

Headquarters: Xi’an, Shaanxi, China
Key Offering: Lentinan powder (purity 98%+), customized extracts for anti-cancer formulations

Based in China’s biotech hub, Xi’an Yuansun excels in natural product extraction and supplies pharma-grade Lentinan to both domestic and international markets. The company leverages advanced chromatography for purification, serving the growing Asian pharmaceutical sector where traditional medicine meets modern oncology. Their products support research into Lentinan’s role as an adjuvant in cancer care.

Research and Development Initiatives:

• Focus on scaling production for high-purity segments targeting $20 million by 2029
• Partnerships with Chinese pharma giants for drug integration

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7️⃣ 4. Golden Horizon Biologics

Headquarters: Xi’an, China
Key Offering: Pharma-grade Lentinan (below and above 98% purity), polysaccharides for health products

Golden Horizon Biologics is a key player in botanical extracts, offering Lentinan that meets stringent pharmaceutical standards. With exports to Europe and North America, they cater to the health product field, where Lentinan enhances immune supplements. The company’s GMP-certified facilities ensure reliability for both research and commercial applications.

Research and Development Initiatives:

• Goal to achieve 15% market share in the purity above 98% segment
• Innovation in nano-encapsulation for improved Lentinan absorption

Download FREE Sample Report: Pharma Grade Lentinan Market – View in Detailed Research Report

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6️⃣ 5. Acetar Bio-Tech Co., Ltd.

Headquarters: Xi’an, China
Key Offering: Lentinan extracts (purity below 98% for supplements), high-grade for pharma use

Acetar Bio-Tech focuses on mushroom-derived bioactives, providing affordable Lentinan options for the burgeoning health supplement market. Their products are integral to formulations aimed at immune support, with growing adoption in North American wellness brands. The company’s vertical integration from cultivation to extraction minimizes costs while maintaining quality.

Research and Development Initiatives:

• Exploration of Lentinan in preventive health products
• Targets net-zero production emissions through eco-friendly sourcing

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5️⃣ 6. Johncan Mushroom Bio-technology Co., Ltd.

Headquarters: Fujian, China
Key Offering: Pharmaceutical Lentinan (above 98% purity), beta-glucans for oncology and immunity

Johncan is a pioneer in mushroom biotechnology in China, leading in Lentinan production with state-of-the-art fermentation tech. They supply to global pharma companies, contributing significantly to the anti-cancer drug segment, which holds the largest market share. Their commitment to R&D has positioned them as a top exporter in Asia.

Research and Development Initiatives:

• Current output exceeds 500 tons annually for pharma applications
• Aiming for doubled capacity by 2026 to meet rising demand

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4️⃣ 7. Mushroom Wisdom, Inc.

Headquarters: East Rutherford, New Jersey, USA
Key Offering: Lentinan-rich extracts (pharma-grade), integrated beta-glucan products

Mushroom Wisdom, a U.S.-based firm with Japanese roots, specializes in clinically studied Lentinan formulations. They bridge traditional shiitake benefits with modern pharma needs, supplying for both drugs and supplements. Their products are backed by decades of research, making them a trusted name in the Western market.

Research and Development Initiatives:

• Clinical studies on Lentinan for breast and lung cancer support
• Expansion into U.S. FDA-compliant production lines

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3️⃣ 8. Real Mushrooms Ltd.

Headquarters: Gibsons, British Columbia, Canada
Key Offering: Pure Lentinan powders (98%+ purity), organic pharma ingredients

Real Mushrooms emphasizes transparency and potency in their Lentinan offerings, serving the North American pharma and health sectors. With a focus on whole-food derived extracts, they avoid fillers, appealing to quality-conscious manufacturers. Their growth aligns with the rising interest in natural cancer adjuncts.

Research and Development Initiatives:

• Indigenous cultivation research for higher beta-glucan yields
• Collaborations for scaling in the health product field

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2️⃣ 9. NK Ingredients Pte. Ltd.

Headquarters: Singapore
Key Offering: Lentinan isolates (pharma-grade), polysaccharides for global supply chains

NK Ingredients operates across Asia-Pacific, providing Lentinan to pharmaceutical hubs in Japan and China. Their expertise in purification supports the purity above 98% segment, crucial for injectable drugs. The company’s logistics network ensures timely delivery for time-sensitive research projects.

Research and Development Initiatives:

• Investment in biotech for enhanced Lentinan stability
• Strategic alliances for entering European markets

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1️⃣ 10. Supersmart (Hifas da Terra)

Headquarters: Lugo, Spain
Key Offering: European pharma-grade Lentinan, beta-glucan complexes for therapy

Supersmart leads in Europe with innovative Lentinan products tailored for the EU’s strict regulations. They focus on sustainable sourcing and supply to oncology centers, where Lentinan aids in reducing chemotherapy side effects. Their R&D emphasizes integration with other mushroom bioactives for synergistic effects.

Research and Development Initiatives:

• End-to-end solutions for clinical trial materials
• Partnerships with EU research institutes for new applications

Read Full Report: Pharma Grade Lentinan Market – View in Detailed Research Report

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🌍 Outlook: The Future of Pharma Grade Lentinan Is Innovative and Accessible

The pharma grade Lentinan market is experiencing transformative growth. While high-purity products dominate for anti-cancer applications, the sector is pouring resources into expanding accessibility, advanced extraction methods, and broader therapeutic uses beyond oncology.

Because of increasing evidence from clinical studies, particularly in Japan and emerging Asian markets, Lentinan is poised to play a larger role in personalized medicine. However, challenges like supply chain dependencies on mushroom cultivation persist, driving investments in synthetic biology alternatives. Furthermore, the health product segment offers untapped potential as consumers seek natural immune boosters.

The U.S. market, estimated at $10 million in 2022, reflects steady demand from supplement innovators, while China is forecasted to surge past $30 million by 2029, fueled by domestic pharma expansions. The purity below 98% segment, ideal for cost-effective supplements, is expected to reach $25 million with an 8% CAGR over the next six years, whereas above 98% purity will lead premium pharma uses.

📈 Key Trends Shaping the Market:

• Expansion of Lentinan production capacity in Asia and North America
• Regulatory advancements for beta-glucan approvals in cancer therapies by 2029
• Digital tracking of supply chains for purity and sustainability verification
• Pharma-nutraceutical partnerships to blend Lentinan into daily health regimens

Global segmentation highlights Asia’s dominance with over 60% share in 2022, driven by Japan and China, followed by North America’s growing adoption in integrative medicine. Europe trails but shows promise through research funding, while South America and Middle East & Africa represent emerging opportunities as awareness spreads.

By type, the above 98% purity segment commands 55% of the market, essential for injectable drugs, while below 98% suits oral supplements. Applications wise, anti-cancer drugs hold 45%, health products 35%, and others like antiviral research 20%.

Read Full Report: Pharma Grade Lentinan Market – View in Detailed Research Report

The companies listed above are not only supplying pharma grade Lentinan—they’re pioneering the natural revolution in immunotherapy and wellness.

At 24chemicalresearch, we provide comprehensive market intelligence that empowers businesses to navigate complex landscapes. Our reports, built on rigorous surveys of manufacturers, suppliers, and experts, offer insights into revenues, sales volumes, and competitive dynamics. From global overviews to regional breakdowns, including North America (U.S., Canada, Mexico), Europe (Germany, France, U.K., Italy, Russia, Nordic, Benelux, Rest), Asia (China, Japan, South Korea, Southeast Asia, India, Rest), South America (Brazil, Argentina, Rest), and Middle East & Africa (Turkey, Israel, Saudi Arabia, UAE, Rest), we cover it all. Dive deeper into segments by type (Purity Below 98%, Above 98%) and application (Anti-Cancer Drug, Health Product Field, Others) to strategize effectively. With data from 2018-2029, including post-COVID and geopolitical impacts, our analysis helps assess drivers like rising cancer incidences, challenges such as raw material volatility, and opportunities in sustainable biotech.

This detailed profile underscores how these leaders are positioning Lentinan not just as a niche compound, but as a cornerstone of future health innovations. As research evolves, expect more integrations with precision medicine, potentially elevating market values beyond projections. For those in pharma, biotech, or nutraceuticals, staying ahead means understanding these dynamics today.