The Global 1,1-Cyclobutanedicarboxylic Acid Market was valued at US$ 45.8 Million in 2024 and is projected to reach US$ 68.3 Million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 5.1% during the forecast period (2024–2032). This growth is fueled by increasing demand for pharmaceutical intermediates, particularly in platinum-based anticancer drugs, and expanding applications in polymer production and specialty chemical synthesis.

As the pharmaceutical industry intensifies its focus on precision oncology treatments, the spotlight falls on chemical manufacturers producing high-purity 1,1-Cyclobutanedicarboxylic Acid (1,1-CBDA, CAS 5445-51-2). This critical building block serves as the carboxylate ligand in carboplatin and other platinum coordination complexes. Our analysis profiles the Top 10 Companies in the 1,1-Cyclobutanedicarboxylic Acid Industry—specialty chemical producers and GMP-compliant manufacturers enabling next-generation cancer therapies.

---

🔟 1. Zhejiang Taizhou Huangyan Goss Pharm. Chem.

Headquarters: Taizhou, China
Key Offering: 1,1-CBDA (Pharma Grade 98-99.5%)

This Chinese manufacturer dominates global 1,1-CBDA production with vertically integrated synthesis capabilities. Their FDA-inspected facility supplies major API producers with cGMP-compliant cyclobutanedicarboxylic acid for platinum drug formulations.

Manufacturing Edge:

• 1,200 metric ton annual capacity
• Patented crystallization technology achieving <0.1% impurities
• Full analytical method validation packages

Download FREE Sample Report: 1,1-Cyclobutanedicarboxylic Acid Market – View in Detailed Research Report

---

9️⃣ 2. Minakem

Headquarters: Beuvry-la-Forêt, France
Key Offering: Ultra-pure 1,1-CBDA (99.9% GC)

The European CDMO specializes in high-purity oncology intermediates, supplying innovator pharma companies with 1,1-CBDA that meets stringent ICH Q3D elemental impurity guidelines.

Technical Advantages:

• Dedicated high-potency API production suites
• Micro-scale batch precision for clinical trial materials
• Comprehensive genotoxic impurity controls

---

8️⃣ 3. Hubei Aoks Bio-Tech

Headquarters: Wuhan, China
Key Offering: Technical and Pharma Grade 1,1-CBDA

Hubei Aoks operates one of Asia’s most automated 1,1-CBDA facilities, serving both bulk chemical buyers and precision drug manufacturers with dual-track production capabilities.

Scale Advantages:

• Continuous flow chemistry implementation
• Residual solvent levels <10 ppm
• Custom particle size distribution options

---

7️⃣ 4. Capot Chemical

Headquarters: Hangzhou, China
Key Offering: Documentation-rich 1,1-CBDA

Capot has emerged as a preferred supplier for regulated markets, offering full analytical documentation including HPLC chromatograms, GC profiles, and elemental analysis reports with each batch.

Quality Systems:

• Strict polymorph control (Form I only)
• Metal content <1 ppm (Pd, Pt, Ni)
• ICH stability study data available

Download FREE Sample Report: 1,1-Cyclobutanedicarboxylic Acid Market – View in Detailed Research Report

---

6️⃣ 5. Nanjing Winsome Chemical

Headquarters: Nanjing, China
Key Offering: 1,1-CBDA and customized derivatives

This specialty manufacturer provides comprehensive cyclobutane chemistry solutions, including deuterated analogs and fluorinated derivatives for drug metabolism studies.

R&D Capabilities:

• Structure-activity relationship modifications
• Position-specific isotope labeling
• Chiral resolution services

---

5️⃣ 6. Veeprho Pharmaceuticals

Headquarters: Mumbai, India
Key Offering: Cost-optimized GMP 1,1-CBDA

Veeprho bridges the gap between quality and affordability, supplying both generic and innovator pharmaceutical companies with validated synthesis routes that reduce platinum catalyst requirements by 30%.

Process Innovations:

• Greener synthetic pathways
• Closed-system crystallization
• Scale-up to metric ton quantities

---

4️⃣ 7. Henan Allgreen Chemical

Headquarters: Zhengzhou, China
Key Offering: Industrial-grade 1,1-CBDA

Allgreen focuses on price-sensitive applications, offering technically pure 1,1-CBDA for polymer modification and specialty material synthesis at competitive costs.

Economic Benefits:

• 20-25% lower production costs
• Bulk packaging options (1-ton supersacks)
• Just-in-time inventory programs

---

3️⃣ 8. Anstar New Material

Headquarters: Shanghai, China
Key Offering: Specialty 1,1-CBDA formulations

Anstar specializes in material science applications, developing modified cyclobutane dicarboxylate compounds for advanced polymer systems and coordination chemistry applications.

Material Focus:

• Thermoset resin hardeners
• Metal-organic framework precursors
• Photoactive derivatives

Download FREE Sample Report: 1,1-Cyclobutanedicarboxylic Acid Market – View in Detailed Research Report

---

2️⃣ 9. Jiangsu Aikon Biopharma

Headquarters: Changzhou, China
Key Offering: Regulatory-supported 1,1-CBDA

Aikon’s dedicated oncology intermediate facility provides comprehensive regulatory documentation including DMF/EDMF files and complete method validation packages.

Compliance Strengths:

• Process validation reports
• Extractable/leachable studies
• Residual solvent optimization

---

1️⃣ 10. ChemScence

Headquarters: Suzhou, China
Key Offering: Research-scale 1,1-CBDA solutions

This emerging player caters to drug discovery teams, offering milligram-to-kilogram quantities of specialized 1,1-CBDA derivatives for preclinical development.

Custom Services:

• Mechanistic probe molecules
• Stable isotope labeled compounds
• Process chemistry DOEs

Get Full Report Here: 1,1-Cyclobutanedicarboxylic Acid Market – View in Detailed Research Report

---

🔬 Outlook: Evolving Standards in Precision Oncology Intermediates

The 1,1-Cyclobutanedicarboxylic Acid market is undergoing transformation as regulatory agencies implement stricter controls on genotoxic impurities and pharmaceutical companies demand higher purity standards for platinum drug synthesis.

🧪 Key Market Trends:

• FDA/EMA requirements for lower metal residues in API starting materials
• Growing adoption of continuous manufacturing processes
• Increasing importance of solid-state characterization
• Emerging applications in targeted protein degraders (PROTACs)

Get Full Report Here: 1,1-Cyclobutanedicarboxylic Acid Market – View in Detailed Research Report

These market leaders are innovating beyond traditional applications, developing advanced cyclobutane derivatives that enable breakthroughs in precision cancer medicines and high-performance materials.