The Global Chlorodifluoroacetic Anhydride Market was valued at USD 0.9 Million in 2024 and is projected to reach USD 1.3 Million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 3.8% during the forecast period (2024–2032). This growth is driven by increasing demand for fluorinated intermediates in pharmaceutical synthesis and advanced material production across key industries.

As specialty chemical applications require more sophisticated fluorine-based compounds, chlorodifluoroacetic anhydride (CAS 2834-23-3) has become essential for creating high-value fluorochemicals. This report examines the Top 10 Companies in the Chlorodifluoroacetic Anhydride Industry—the chemical manufacturers and technology innovators defining this specialized market segment.

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🔟 1. New Fluorine Chemical

Headquarters: Taizhou, China
Key Offering: 98-99% Purity Grades

As China’s leading fluorochemical producer, New Fluorine Chemical operates one of Asia’s largest dedicated production facilities with advanced fluorination capabilities. The company serves global pharmaceutical and agrochemical manufacturers with cGMP-compliant intermediates.

Production Capacity:

• 800+ metric tons annual output
• New automated production line added in 2024
• R&D focus on lower-waste fluorination processes

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9️⃣ 2. Nantong Baokai Pharmaceutical

Headquarters: Jiangsu, China
Key Offering: Pharmaceutical Intermediates

Specializing in fluorine-containing API building blocks, Nantong Baokai produces high-purity chlorodifluoroacetic anhydride under strict quality systems. Their products are widely used in antiviral and oncology drug development.

Quality Certifications:

• FDA-inspected facility
• EDQM CEP certifications for key intermediates

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8️⃣ 3. Fluoropharm

Headquarters: Hubei, China
Key Offering: Technical & Custom Grades

Fluoropharm’s flexible production allows for customized fluorochemical solutions. The company has invested heavily in continuous flow reactor technology to improve yield and reduce environmental impact.

Process Innovation:

• Closed-loop solvent recovery systems
• 35% capacity expansion in 2023

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7️⃣ 4. Hangzhou FandaChem

Headquarters: Zhejiang, China
Key Offering: Multi-purity Grades

FandaChem serves both research institutions and industrial customers through its extensive distribution network. The company maintains strategic inventory positions in North America and Europe to ensure reliable supply.

Market Position:

• 25% year-over-year sales growth
• ISO 9001 certified operations

Download FREE Sample Report: Chlorodifluoroacetic Anhydride Market – View in Detailed Research Report

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6️⃣ 5. Zhejiang Jitai New Materials

Headquarters: Zhejiang, China
Key Offering: Bulk Industrial Grades

Jitai focuses on cost-effective production for industrial applications. Their manufacturing complex integrates fluorine raw material production with downstream processing for maximum efficiency.

Scale Advantages:

• 10,000-ton fluorochemical capacity
• Automated quality control systems

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5️⃣ 6. Shanghai Rolechem

Headquarters: Shanghai, China
Key Offering: Lab to Commercial Scale

Rolechem provides critical development quantities of chlorodifluoroacetic anhydride to pharmaceutical researchers while also supplying production-scale volumes. Their technical team offers customized analytical support.

Research Support:

• Custom purity specifications
• Method development assistance

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4️⃣ 7. Hubei Norna Technology

Headquarters: Hubei, China
Key Offering: Integrated Fluorochemical Solutions

Norna’s vertical integration extends from hydrofluoric acid production through high-value fluorinated intermediates. Their chlorodifluoroacetic anhydride features exceptionally low metal impurities.

Technical Capabilities:

• Sub-ppm metal content grades
• Electronic materials expertise

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3️⃣ 8. Shanghai YouLi Chemical

Headquarters: Shanghai, China
Key Offering: Regulated Market Products

YouLi specializes in documentation packages that meet global regulatory requirements. Their DMF filings and comprehensive analytical data support pharmaceutical customers through the approval process.

Regulatory Support:

• Complete ICH impurity profiles
• Stability data packages

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2️⃣ 9. Shanghai Yingsheng Pharmaceutical

Headquarters: Shanghai, China
Key Offering: High-Purity API Intermediates

As a CDMO with fluorine chemistry expertise, Yingsheng helps clients optimize synthetic routes using chlorodifluoroacetic anhydride. Their process development services reduce costs and improve yields.

Process Development:

• Route scouting and optimization
• Scale-up technical transfer

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1️⃣ 10. Tokyo Chemical Industry (TCI)

Headquarters: Tokyo, Japan
Key Offering: Research-Grade Chemicals

TCI supplies the global scientific community with high-purity chlorodifluoroacetic anhydride for laboratory use. While not a bulk manufacturer, their exacting standards make them essential for method development.

Scientific Resources:

• Comprehensive safety data
• Technical bulletins and applications notes

Read Full Report: Chlorodifluoroacetic Anhydride Market – View in Detailed Research Report

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🔬 Market Outlook: Expanded Applications Driving Demand

Chlorodifluoroacetic anhydride consumption is growing as new pharmaceutical candidates and high-performance materials incorporate fluorine atoms. The market is seeing increased innovation in both production methods and end-use applications.

📊 Key Market Trends:

• Growing use in protease inhibitor drugs and CNS therapeutics
• Emerging applications in liquid crystal polymers and advanced coatings
• Increasing environmental regulations affecting production methods
• Supply chain diversification efforts by Western buyers

Read Full Report: Chlorodifluoroacetic Anhydride Market – View in Detailed Research Report

The profiled companies are advancing fluorine chemistry through their chlorodifluoroacetic anhydride expertise, enabling critical innovations across multiple high-tech industries.