The Global Solid Phase Synthesis Carrier for Nucleic Acid Drugs Market was valued at USD 58.4 million in 2024 and is projected to reach USD 112 million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 10.1% during the forecast period (2024–2032). This expansion is being driven by the rapid development of RNA-based therapeutics, increasing adoption of precision medicine approaches, and advancements in oligonucleotide manufacturing technologies.
As the pharmaceutical industry shifts toward nucleic acid-based treatments for genetic disorders, cancers and infectious diseases, the demand for high-performance synthesis carriers has intensified. These critical materials – including CPG (Controlled Pore Glass) and polystyrene resins – serve as the foundation for producing oligonucleotides with the purity and consistency required for therapeutic applications. Here we examine the Top 10 Companies in the Solid Phase Synthesis Carrier Market that are enabling the next generation of genetic medicines.
🔟 1. Nitto Denko Corporation
Headquarters: Osaka, Japan
Key Offering: CPG carriers, functionalized polystyrene resins
A leader in materials science, Nitto Denko provides high-performance synthesis carriers specifically engineered for nucleic acid drug production. Their proprietary surface treatments and pore size distributions optimize coupling efficiency across multiple synthesis scales.
Core Strengths:
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Patented manufacturing processes ensuring batch-to-batch consistency
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Diverse portfolio addressing research, clinical and commercial needs
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GMP-compliant production facilities supporting pharma applications
Download FREE Sample Report: Solid Phase Synthesis Carrier for Nucleic Acid Drugs Market – View in Detailed Research Report
9️⃣ 2. Sunresin New Materials Co., Ltd.
Headquarters: Xi’an, China
Key Offering: Polystyrene-based synthesis supports
Sunresin has emerged as China’s leading supplier of nucleic acid synthesis carriers, combining technical expertise with cost-effective manufacturing capabilities. Their products are increasingly adopted by biopharmaceutical companies throughout Asia.
Market Position:
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Strategic supplier to China’s growing oligonucleotide API manufacturers
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Expanding presence in international CDMO partnerships
8️⃣ 3. Cytiva (Danaher Corporation)
Headquarters: Marlborough, Massachusetts, USA
Key Offering: Sepharose-based synthesis media
Leveraging its extensive expertise in bioprocessing, Cytiva offers specialized carriers that integrate seamlessly with automated oligonucleotide synthesizers. Their products are particularly favored for mRNA therapeutic production.
Process Advantages:
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Carriers optimized for therapeutic-scale production volumes
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Compatibility with major synthesizer platforms
7️⃣ 4. Tianjin Nankai Hecheng Science & Technology Co., Ltd.
Headquarters: Tianjin, China
Key Offering: Cost-effective CPG carriers
This specialized manufacturer provides affordable, high-quality synthesis supports primarily serving China’s domestic nucleic acid drug market while expanding into Southeast Asia and Middle Eastern markets.
Regional Focus:
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Strategic partnerships with Chinese biotech innovators
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Increasing GMP capabilities for pharmaceutical applications
6️⃣ 5. Suzhou Nanomicro Technology Co., Ltd.
Headquarters: Suzhou, China
Key Offering: Silica-based synthesis matrices
Nanomicro Technology specializes in innovative silica carriers that combine inorganic stability with organic functionality, particularly effective for modified nucleotide incorporation.
Technical Expertise:
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Advanced surface modification techniques
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High-density loading capabilities
Download FREE Sample Report: Solid Phase Synthesis Carrier for Nucleic Acid Drugs Market – View in Detailed Research Report
5️⃣ 6. ChemGenes Corporation
Headquarters: Wilmington, Massachusetts, USA
Key Offering: Specialty CPG supports
ChemGenes focuses on high-purity synthesis carriers for therapeutic oligonucleotide production, with rigorous quality control ensuring exceptional consistency between batches.
Quality Focus:
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GMP-grade materials with full documentation
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Designed for scale-up manufacturing
4️⃣ 7. Merck KGaA
Headquarters: Darmstadt, Germany
Key Offering: Premier CPG and PS resins
Through its Novabiochem brand, Merck provides research and GMP-grade synthesis carriers benefiting from the company’s extensive experience in nucleic acid and peptide synthesis reagents.
Global Leadership:
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Comprehensive product portfolio
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Reliable worldwide distribution network
3️⃣ 8. Bio-Synthesis, Inc.
Headquarters: Lewisville, Texas, USA
Key Offering: Customized synthesis supports
Bio-Synthesis specializes in developing tailored carriers for challenging oligonucleotide modifications and specialized research applications.
Niche Capabilities:
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Proprietary surface chemistries
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Flexible small-batch production
2️⃣ 9. PolyOrg, Inc.
Headquarters: Leominster, Massachusetts, USA
Key Offering: High-capacity polymeric resins
PolyOrg focuses on advanced polystyrene-based carriers engineered for maximum oligonucleotide loading capacity and synthesis efficiency.
Innovation Focus:
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Proprietary crosslinking technologies
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Optimized swelling properties
1️⃣ 10. Tokyo Chemical Industry Co., Ltd. (TCI)
Headquarters: Tokyo, Japan
Key Offering: Research-grade synthesis carriers
TCI serves the academic and biotech research communities with an extensive catalog of derivatized supports for oligonucleotide synthesis and modification studies.
Research Support:
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Broad selection of functionalized carriers
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Rapid development of new chemistries
Get Full Report Here: Solid Phase Synthesis Carrier for Nucleic Acid Drugs Market – View in Detailed Research Report
🔬 Future Outlook: Enabling Next-Generation Nucleic Acid Medicines
The solid phase synthesis carrier market is evolving rapidly to meet the needs of advanced nucleic acid therapeutics. As drug developers create more complex oligonucleotides with diverse modifications, carrier technologies must advance in parallel to ensure efficient, high-yield synthesis.
🧬 Key Market Developments:
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Carriers optimized for large-scale GMP manufacturing
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Advanced surface chemistries for challenging modifications
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Integration with continuous flow synthesis systems
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Materials minimizing side reactions and maximizing purity
Get Full Report Here: Solid Phase Synthesis Carrier for Nucleic Acid Drugs Market – View in Detailed Research Report
The companies profiled above form the essential supply chain enabling the development of groundbreaking nucleic acid therapeutics that are transforming modern medicine.
