The Global Multimodal Chromatography Resin Market was valued at USD 1.35 Billion in 2023 and is projected to reach USD 2.46 Billion by 2032, growing at a Compound Annual Growth Rate (CAGR) of 6.9% during the forecast period (2023–2032). This robust growth is driven by increasing demand for biopharmaceuticals, stringent regulatory requirements for drug purity, and the superior selectivity offered by multimodal resins in complex biomolecule separations.

As the bioprocessing industry evolves toward next-generation therapeutics, these advanced purification materials have become indispensable for monoclonal antibodies, vaccines, and gene therapies. This analysis spotlights the Top 10 Companies in the Multimodal Chromatography Resin Industry—technology innovators setting new standards in downstream processing efficiency and purification performance.

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🔟 1. Cytiva (formerly GE Healthcare Life Sciences)

Headquarters: Marlborough, Massachusetts, USA
Key Offering: Capto™ multimodal resin series

As the market leader with over 35% global share, Cytiva’s Capto platform dominates industrial-scale biologics purification. The company’s continuous innovation in ligand chemistry has established new benchmarks for binding capacity and flow characteristics.

Technology Leadership:

• Capto MMC for mixed-mode cation exchange applications
• Capto adhere for polishing complex antibody mixtures
• Pre-packed column solutions for single-use bioprocessing

Download FREE Sample Report: Multimodal Chromatography Resin Market – View in Detailed Research Report

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9️⃣ 2. Merck Millipore (Merck KGaA)

Headquarters: Darmstadt, Germany
Key Offering: Eshmuno® HCX and Fractogel® EMD resins

Merck’s life science division combines German engineering with global manufacturing scale, offering resins that achieve >99.5% purity in monoclonal antibody production.

Technology Leadership:

• High-capacity salt-tolerant chemistries
• GMP+ certified manufacturing facilities
• Integrated purification workflows for viral vectors

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8️⃣ 3. Thermo Fisher Scientific

Headquarters: Waltham, Massachusetts, USA
Key Offering: POROS™ XS/HS and CaptureSelect™ resins

Thermo Fisher’s acquisition strategy has created a comprehensive chromatography portfolio serving both research-scale and commercial bioproduction needs.

Technology Leadership:

• High-flow porous polymer resins
• Affinity ligands for Fc fusion proteins
• Ready-to-use process chromatography columns

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7️⃣ 4. Bio-Rad Laboratories

Headquarters: Hercules, California, USA
Key Offering: Nuvia® and CHT™ ceramic hydroxypatite resins

Bio-Rad’s biocompatible resin technology excels in difficult separations, particularly for viruses and large biomolecules where traditional resins struggle.

Technology Leadership:

• Ceramic-based matrix for exceptional stability
• Nuvia cPrime for intermediate purification
• Validated platforms for vaccine production

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6️⃣ 5. Tosoh Bioscience

Headquarters: Tokyo, Japan
Key Offering: TOYOPEARL® MX-Trp resins

The Japanese specialty chemical manufacturer provides high-performance resins with particular strengths in Asia-Pacific biomanufacturing markets.

Technology Leadership:

• Hydrophobic charge induction chromatography
• Large particle sizes for high flow rates
• Stable performance across extreme pH ranges

Download FREE Sample Report: Multimodal Chromatography Resin Market – View in Detailed Research Report

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5️⃣ 6. Repligen Corporation

Headquarters: Waltham, Massachusetts, USA
Key Offering: OPUS® and Atoll® process chromatography resins

Through strategic acquisitions, Repligen has rapidly become a key supplier of novel chromatography solutions for gene therapy applications.

Technology Leadership:

• High-capacity capture resins
• Single-use prepacked columns
• AAV and lentivirus purification platforms

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4️⃣ 7. Mitsubishi Chemical Group

Headquarters: Tokyo, Japan
Key Offering: Seplife® BigBeads technology

The chemical conglomerate’s life sciences division focuses on large-particle resins for high-flow industrial bioprocessing.

Technology Leadership:

• 150μm+ particle size distribution
• High dynamic binding capacity
• Reduced pressure drop in large-scale columns

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3️⃣ 8. Purolite Life Sciences

Headquarters: King of Prussia, Pennsylvania, USA
Key Offering: Praesto® and Lifetech™ ECR resins

Purolite provides cost-optimized alternatives for biosimilar and generic biologic manufacturers without compromising performance.

Technology Leadership:

• Competitive binding capacities
• Custom ligand development services
• Robust sanitization protocols

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2️⃣ 9. Danaher (Pall Corporation)

Headquarters: Washington, DC, USA
Key Offering: Mustang® membrane chromatography

Danaher’s bioprocessing unit pioneered membrane chromatography as an alternative to packed-bed resin columns for flow-through polishing.

Technology Leadership:

• High-throughput membrane adsorbers
• Single-use capsule formats
• Viral clearance validation packages

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1️⃣ 10. JSR Micro

Headquarters: Tokyo, Japan
Key Offering: FineLINE® and NanoCrystal™ affinity resins

JSR combines polymer science expertise with bioprocessing knowledge to create innovative affinity-mimetic ligands.

Technology Leadership:

• Molecular-imprinted ligands
• High-resolution separation media
• Novel bead architectures for improved kinetics

Get Full Report Here: Multimodal Chromatography Resin Market – View in Detailed Research Report

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🔬 Market Outlook: The Next Frontier in Bioprocessing Purification

The multimodal chromatography resin sector is undergoing rapid transformation as biologics manufacturing evolves. Emerging applications in cell/gene therapies and mRNA vaccines are driving demand for more selective, higher-capacity purification solutions.

📈 Key Industry Trends:

• Shift toward continuous bioprocessing configurations
• Growing adoption of salt-tolerant chemistries to simplify buffer systems
• Increasing use in viral vector purification for advanced therapies
• Development of affinity-mimetic ligands for difficult separations

These market leaders continue to invest heavily in R&D, with particular focus on improving binding capacities, sanitization protocols, and cost efficiencies for large-scale manufacturing.

Get Full Report Here: Multimodal Chromatography Resin Market – View in Detailed Research Report