R-452B (GWP 676) as Low GWP Replacement for R-410A in Air Conditioners Market (2026): Market Leaders Powering Global Cooling

MARKET INSIGHTS

The Global R-452B (GWP 676) as low GWP replacement for R-410A in air conditioners market size was valued at USD 1.87 billion in 2025. The market is projected to grow from USD 2.14 billion in 2026 to USD 5.63 billion by 2034, exhibiting a CAGR of 11.4% during the forecast period.

R-452B is a non-flammable, hydrofluoroolefin (HFO)-based refrigerant blend composed of R-32, R-125, and R-1234yf, engineered as a lower global warming potential (GWP) alternative to R-410A, which carries a GWP of 2,088. With a GWP of 676 – approximately 68% lower than R-410A – R-452B offers a thermodynamic performance profile closely aligned with its predecessor, making it a practical near-drop-in solution for residential and commercial air conditioning systems without requiring major equipment redesign.

R-452B is gaining significant momentum, driven by increasingly stringent global refrigerant regulations, particularly under the Kigali Amendment to the Montreal Protocol, which mandates a phasedown of high-GWP hydrofluorocarbons (HFCs). Furthermore, the European F-Gas Regulation and similar policies across North America and Asia-Pacific are accelerating the transition away from R-410A. Leading refrigerant manufacturers such as Chemours, Honeywell, and Daikin have been actively advancing R-452B adoption across their product lines, reinforcing supply chain readiness and market confidence.

R-452B (GWP 676) as Low GWP Replacement for R-410A in Air Conditioners Market – View in Detailed Research Report

Top 10 Companies Driving the R-452B Market

1️⃣ Chemours

Headquarters: Wilmington, Delaware, USA
Key Offering: Opteon™ XL55 refrigerant blend

Chemours has pioneered the commercial production of R-452B, providing a reliable supply chain and extensive R&D to ensure safety and performance across HVAC platforms. Their expertise in HFO chemistry underpins the blend’s low GWP and near-drop-in compatibility with existing R-410A systems.

Sustainability Initiatives:

• Investing in advanced HFO manufacturing to reduce carbon footprint.
• Collaborating with OEMs to certify low-GWP solutions.
• Committing to 100% renewable energy in production facilities.

2️⃣ Honeywell

Headquarters: Charlotte, North Carolina, USA
Key Offering: Solstice® N41 refrigerant blend

Honeywell’s Solstice® line positions R-452B as a key transitional refrigerant for split-system air conditioners, offering competitive performance while meeting regulatory mandates.

Sustainability Initiatives:

• Expanding HFO production capacity to meet global demand.
• Partnering with HVAC manufacturers to reduce lifecycle emissions.
• Investing in carbon offset projects for refrigerant manufacturing.

3️⃣ Daikin

Headquarters: Osaka, Japan
Key Offering: Opteon™ XL55 and other A2L blends

Daikin has integrated R-452B into its residential and light commercial product lines, leveraging its extensive global distribution network to accelerate adoption.

Sustainability Initiatives:

• Targeting 30% reduction in refrigerant GWP across product portfolio.
• Implementing circular refrigerant management programs.
• Investing in renewable energy for manufacturing plants.

4️⃣ Carrier (Johnson Controls)

Headquarters: Milwaukee, Wisconsin, USA
Key Offering: Puron Advance™ and other A2L solutions

Carrier’s Puron Advance™ platform demonstrates the feasibility of R-452B in residential HVAC, offering comparable efficiency with lower GWP.

Sustainability Initiatives:

• Adopting low-GWP refrigerants across 90% of new product lines.
• Reducing energy consumption in manufacturing through process optimization.
• Supporting green building certifications worldwide.

5️⃣ Trane Technologies

Headquarters: Chicago, Illinois, USA
Key Offering: A2L refrigerant integration in commercial units

Trane has announced R-452B compatible platforms for rooftop units and VRF systems, positioning itself as a leader in the commercial segment.

Sustainability Initiatives:

• Setting 50% reduction in refrigerant GWP by 2030.
• Implementing closed-loop refrigerant recovery systems.
• Partnering with utilities to promote energy-efficient HVAC.

6️⃣ Midea

Headquarters: Beijiao, China
Key Offering: Low-GWP refrigerant blends for residential units

Midea’s adoption of R-452B in its large domestic market underscores the blend’s global appeal and the company’s commitment to regulatory compliance.

Sustainability Initiatives:

• Reducing refrigerant GWP by 40% across product lines.
• Investing in renewable energy for production plants.
• Developing smart HVAC solutions for energy savings.

7️⃣ Lennox

Headquarters: Tulsa, Oklahoma, USA
Key Offering: Low-GWP refrigerant solutions for residential air conditioners

Lennox’s focus on R-452B demonstrates its strategy to offer high-efficiency, low-carbon HVAC systems.

Sustainability Initiatives:

• Targeting 30% reduction in refrigerant GWP by 2030.
• Implementing eco-friendly manufacturing practices.
• Engaging in community outreach on climate action.

8️⃣ Rheem

Headquarters: Atlanta, Georgia, USA
Key Offering: Low-GWP refrigerant blends for residential and light commercial units

Rheem’s integration of R-452B into its product portfolio showcases its commitment to sustainable HVAC solutions.

Sustainability Initiatives:

• Reducing refrigerant GWP by 35% across new products.
• Investing in renewable energy for manufacturing.
• Collaborating with OEMs on green building projects.

9️⃣ York (Johnson Controls)

Headquarters: Milwaukee, Wisconsin, USA
Key Offering: Low-GWP refrigerant solutions for commercial HVAC

York’s focus on R-452B supports its strategy to deliver low-carbon commercial HVAC solutions.

Sustainability Initiatives:

• Reducing refrigerant GWP by 30% across commercial product lines.
• Implementing closed-loop refrigerant recovery systems.
• Promoting energy-efficient HVAC in green building projects.

🔟 10️⃣ Johnson Controls

Headquarters: Milwaukee, Wisconsin, USA
Key Offering: Integrated low-GWP HVAC solutions for commercial and industrial markets

Johnson Controls’ broad portfolio includes R-452B-compatible systems, reinforcing its position as a global leader in sustainable HVAC.

Sustainability Initiatives:

• Targeting 50% reduction in refrigerant GWP by 2030.
• Investing in renewable energy for manufacturing and data centers.
• Supporting green building certifications worldwide.

Download FREE Sample Report

R-452B (GWP 676) as Low GWP Replacement for R-410A in Air Conditioners Market – View in Detailed Research Report

Outlook

With regulatory frameworks tightening and OEMs accelerating product launches, the R-452B market is poised for robust growth. The near-drop-in nature of the blend, coupled with its lower GWP, positions it as the preferred transitional refrigerant across residential, light commercial, and commercial segments. By 2034, the market is expected to reach USD 5.63 billion, driven by new equipment sales and a growing retrofit base as the installed R-410A fleet ages.

Future Trends

Key future trends include:

• Continued adoption of R-452B in emerging markets as regulatory mandates extend.
• Advancements in A2L safety standards, reducing barriers for OEMs.
• Integration of R-452B with smart HVAC controls to maximize energy efficiency.
• Potential shift towards even lower-GWP alternatives such as R-32 and R-290, while R-452B serves as a bridge solution.