The Global Biorefining Enzyme Market was valued at USD 8.6 Billion in 2025 and is projected to reach USD 15.9 Billion by 2034, growing at a Compound Annual Growth Rate (CAGR) of 6.9% during the forecast period (2026–2034). This robust expansion is propelled by the global transition to a circular bioeconomy, stringent environmental regulations, and the escalating demand for sustainable biofuels and bio-based chemicals.

Biorefining enzymes, the biological catalysts essential for converting biomass into valuable products, are at the heart of this green industrial revolution. In this blog, we profile the Top 10 Companies in the Biorefining Enzyme Industry—a dynamic mix of biotechnology pioneers, chemical giants, and specialized innovators shaping the future of sustainable manufacturing.

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🔟 1. Novozymes A/S

Headquarters: Bagsværd, Denmark
Key Offering: Cellulase, Amylase, Lipase, and advanced enzyme cocktails

Novozymes is the undisputed global leader in the biorefining enzyme market, with a rich history of innovation in industrial biotechnology. The company provides high-performance enzymatic solutions that are critical for converting agricultural residues, starch, and other biomass into biofuels and biochemicals. Their comprehensive portfolio is designed to maximize yield and efficiency for biorefinery operators worldwide.

Innovation & Sustainability Focus:

• Pioneering research in enzyme efficiency and thermostability
• Strategic partnerships with major biofuel producers for tailored solutions
• Commitment to enabling a circular bioeconomy through advanced biotechnology

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9️⃣ 2. DuPont de Nemours, Inc.

Headquarters: Wilmington, Delaware, USA
Key Offering: Accellerase® cellulase cocktails, specialty enzymes for biomass conversion

DuPont is a major force in industrial enzymes, with a strong focus on developing advanced solutions for lignocellulosic biomass deconstruction. Its acquisition of Danisco’s enzyme business solidified its position, and its Accellerase® product line is widely recognized for enabling efficient second-generation biofuel production from non-food feedstocks.

Innovation & Sustainability Focus:

• Leading R&D in lignocellulosic conversion technologies
• Global supply chain supporting large-scale biorefining operations
• Focus on reducing the cost of advanced biofuel production

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8️⃣ 3. International Flavors & Fragrances Inc. (IFF)

Headquarters: New York, New York, USA
Key Offering: Enzyme solutions for biofuels, food, and feed applications

Following its merger with DuPont’s Nutrition & Biosciences division, IFF has become a powerhouse in the enzyme sector. The company leverages its extensive biotech capabilities to serve the biorefining market, offering enzymes that improve process efficiency and sustainability across multiple industrial applications.

Innovation & Sustainability Focus:

• Integrated portfolio combining enzyme technology with broader biotech solutions
• Strong focus on sustainable ingredient production
• Expanding applications in high-value bio-based chemicals

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7️⃣ 4. BASF SE

Headquarters: Ludwigshafen, Germany
Key Offering: Enzymes for industrial biotechnology and feed applications

BASF, a global chemical giant, maintains a significant presence in the enzyme market through its nutrition and health division. The company develops and supplies enzymes that are crucial for various biorefining processes, including those used in the production of bio-based chemicals and animal feed enhancement.

Innovation & Sustainability Focus:

• Integration of enzymes into broader chemical production value chains
• Research into enzyme applications for plastic biodegradation and recycling
• Commitment to sustainable solutions through its corporate strategy

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Biorefining Enzyme Market – View in Detailed Research Report

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6️⃣ 5. DSM-Firmenich

Headquarters: Kaiseraugst, Switzerland
Key Offering: Specialty enzymes for animal nutrition and bio-industrial applications

DSM-Firmenich, formed by the merger of Royal DSM and Firmenich, is a leading innovator in health, nutrition, and bioscience. The company’s enzyme division focuses on developing solutions that improve the efficiency of agricultural and industrial bioprocesses, contributing to more sustainable production systems.

Innovation & Sustainability Focus:

• Advanced enzyme solutions for feed efficiency and methane reduction
• Development of enzymes for next-generation biorefining processes
• Strong emphasis on science-based sustainability targets

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5️⃣ 6. AB Enzymes GmbH

Headquarters: Darmstadt, Germany
Key Offering: Tailored enzyme solutions for food, feed, and technical applications

AB Enzymes, a subsidiary of Associated British Foods, is a specialized enzyme producer with expertise in developing custom solutions for various industrial processes. The company’s biorefining enzymes are used to enhance the efficiency of biomass conversion and improve the sustainability profile of end products.

Innovation & Sustainability Focus:

• Customized enzyme development for specific customer needs
• Focus on improving process economics through enzymatic solutions
• Applications in waste valorization and resource efficiency

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4️⃣ 7. Amano Enzyme Inc.

Headquarters: Nagoya, Japan
Key Offering: Specialty enzymes for pharmaceutical, food, and industrial use

Amano Enzyme is a respected Japanese company with a long history of enzyme innovation. While strong in food and pharmaceutical applications, the company also contributes to the biorefining sector with enzymes that facilitate the breakdown of complex biomass into usable components for bio-based product manufacturing.

Innovation & Sustainability Focus:

• High-purity enzyme production for specialized applications
• Research into novel enzyme discovery and functionality
• Expanding into bio-industrial enzyme markets

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3️⃣ 8. Metgen Oy

Headquarters: Espoo, Finland
Key Offering: Engineered enzymes for lignocellulosic biomass conversion

Metgen is a technology-driven Finnish company specializing in engineered enzymes for challenging biomass feedstocks. The company’s innovative enzyme technology is designed to efficiently break down lignocellulosic materials, making it a key player in advancing second-generation biorefining capabilities.

Innovation & Sustainability Focus:

• Proprietary enzyme engineering platform technology
• Focus on overcoming biomass recalcitrance for improved yields
• Partnerships with biorefinery developers for technology deployment

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2️⃣ 9. Advanced Enzyme Technologies Ltd.

Headquarters: Mumbai, India
Key Offering: Enzymes for human nutrition, animal feed, and bio-processing

Advanced Enzyme Technologies is a leading Indian enzyme company with growing international presence. The company develops and manufactures enzymes for various applications, including those relevant to biorefining processes, and is expanding its capabilities to serve the global bioeconomy.

Innovation & Sustainability Focus:

• Research on enzyme applications for agricultural waste utilization
• Expanding production capacity for industrial enzymes
• Focus on cost-effective enzyme solutions for emerging markets

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1️⃣ 10. Enzyme Solutions LLC

Headquarters: Waukesha, Wisconsin, USA
Key Offering: Custom enzyme formulations and process optimization services

Enzyme Solutions is a specialized North American company focusing on developing tailored enzymatic solutions for industrial clients. The company works closely with biorefinery operators to optimize their processes through customized enzyme cocktails that improve conversion efficiency and reduce operational costs.

Innovation & Sustainability Focus:

• Customer-specific enzyme formulation development
• Process optimization services for biorefining operations
• Focus on improving the economic viability of bio-based production

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Biorefining Enzyme Market – View in Detailed Research Report

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🌍 Outlook: The Future of Biorefining Enzymes Is Efficient and Sustainable

The biorefining enzyme market is undergoing a significant transformation as the world accelerates its shift toward sustainable production systems. While commodity enzymes still dominate market volume, the industry is investing heavily in advanced enzyme engineering, customized solutions, and innovative applications that extend beyond traditional biofuels.

📈 Key Trends Shaping the Market:

• Rapid advancements in protein engineering and directed evolution techniques
• Growing demand for enzymes tailored to specific regional feedstocks
• Expansion into high-value bio-based chemicals and materials production
• Increasing integration of digital technologies for enzyme performance optimization

Get Full Report Here:
Biorefining Enzyme Market – View in Detailed Research Report

The companies listed above are not only supplying essential catalysts for bio-based production—they’re driving the technological innovation that will enable a truly circular and sustainable global economy.