The Global Pharmaceutical-grade HFA-134a Market was valued at USD 752 Million in 2025 and is projected to reach USD 1,242 Million by 2034, growing at a Compound Annual Growth Rate (CAGR) of 7.7% during the forecast period (2024–2034). This robust growth is primarily driven by the rising global prevalence of respiratory diseases like Asthma and Chronic Obstructive Pulmonary Disease (COPD), stringent phase-out mandates for ozone-depleting CFC propellants, and the increasing demand for reliable, high-purity inhalation drug delivery systems.

Pharmaceutical-grade HFA-134a (1,1,1,2-tetrafluoroethane) is a critical component in Metered-Dose Inhalers (MDIs), ensuring the precise and safe delivery of life-saving medications. Its production requires adherence to the highest purity standards, such as those set by the United States Pharmacopoeia (USP) and the European Pharmacopoeia (EP), typically demanding a purity of ≥99.97% with strict controls on impurities. As the pharmaceutical industry continues to innovate, the companies that produce this essential propellant are at the forefront of global healthcare. In this blog, we profile the Top 10 Companies in the Pharmaceutical-grade HFA-134a Industry—specialty chemical manufacturers and fluorochemical giants ensuring the integrity of inhaled therapies worldwide.

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🔟 1. SRF Limited

Headquarters: Gurugram, Haryana, India
Key Offering: Pharmaceutical-grade HFA-134a (Solstice® 134a)

SRF Limited is a leading global manufacturer of fluorochemicals and a key supplier of high-purity HFA-134a for the pharmaceutical industry. Their technical expertise in fluorine chemistry positions them as a critical partner for inhaler manufacturers, providing propellants that meet rigorous international pharmacopoeia standards.

Key Initiatives & Capabilities:

• Production facilities compliant with cGMP (Current Good Manufacturing Practice) standards

• Strong focus on Research & Development for process optimization and purity enhancement

• Strategic global supply chain to serve pharmaceutical clients across North America, Europe, and Asia

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9️⃣ 2. Koura (a Fluorochem company)

Headquarters: Runcorn, United Kingdom
Key Offering: Zephex® 134a (Pharmaceutical Grade)

Koura, a global leader in the manufacture and supply of fluoroproducts, offers Zephex® 134a, a pharmaceutical-grade HFA propellant. With a heritage in fluorine chemistry, Koura provides a reliable and audited supply essential for the stringent requirements of the global pharmaceutical market.

Key Initiatives & Capabilities:

• World-class manufacturing site with a dedicated pharmaceutical-grade production line

• Comprehensive regulatory support and documentation for global market approvals

• Commitment to sustainable fluorocarbon production and environmental stewardship

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8️⃣ 3. Zhejiang Juhua Co., Ltd. (Juhua shares)

Headquarters: Quzhou, Zhejiang, China
Key Offering: High-purity HFA-134a

Zhejiang Juhua is one of China’s largest fluorochemical producers and a significant player in the regional market for pharmaceutical-grade HFA-134a. The company leverages its integrated fluorine production chain to supply the growing demand for MDI propellants within Asia and internationally.

Key Initiatives & Capabilities:

• Extensive vertical integration in fluorine chemical production

• Focus on expanding production capacity to meet rising domestic and export demand

• Investment in quality control systems to achieve international pharmacopoeia certifications

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7️⃣ 4. The Chemours Company

Headquarters: Wilmington, Delaware, USA
Key Offering: Opteon™ and legacy Freon™ products, including high-purity HFA-134a

As a spin-off from DuPont, Chemours possesses deep historical expertise in fluoroproducts. While its public focus is often on refrigerants, it has the capability and technology to produce the high-purity grades required for pharmaceutical applications, serving a global customer base.

Key Initiatives & Capabilities:

• Legacy of innovation and technical expertise in fluorine-based chemistry

• Global manufacturing footprint with stringent quality assurance protocols

• Ongoing investment in sustainable fluorochemical technologies

Download FREE Sample Report:
Pharmaceutical-grade HFA-134a Market – View in Detailed Research Report

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6️⃣ 5. Arkema S.A.

Headquarters: Colombes, France
Key Offering: Forane® 134a (Pharmaceutical Grade)

Arkema, a major global chemical company, produces Forane® 134a, which is used in various applications, including as a propellant for pharmaceutical MDIs. Their commitment to innovation in materials science extends to providing high-performance solutions for the healthcare sector.

Key Initiatives & Capabilities:

• Strong European manufacturing base serving a key pharmaceutical market

• Focus on product stewardship and regulatory compliance for medical applications

• Diverse fluorochemical portfolio supporting cross-industry applications

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5️⃣ 6. Daikin Industries, Ltd.

Headquarters: Osaka, Japan
Key Offering: High-purity fluorocarbon gases, including HFA-134a

Daikin is a world leader in air conditioning and fluorochemical technology. While its primary focus is on refrigerants, its advanced production capabilities allow it to supply ultra-high-purity grades suitable for sensitive applications like pharmaceutical aerosols.

Key Initiatives & Capabilities:

• Pioneering fluorine chemistry research and development

• State-of-the-art purification technologies to achieve pharmaceutical-grade standards

• Established supply chain networks throughout Asia-Pacific and beyond

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4️⃣ 7. Honeywell International Inc.

Headquarters: Charlotte, North Carolina, USA
Key Offering: Solstice® and Genetron® branded fluoroproducts

Honeywell is a diversified technology giant with a significant fluoroproducts business. It has historically been a major player in the transition from CFCs to HFA propellants and maintains the capability to produce the high-purity materials required for the pharmaceutical industry.

Key Initiatives & Capabilities:

• Extensive intellectual property portfolio in next-generation fluorochemicals

• Global manufacturing and distribution infrastructure

• Active development of lower Global Warming Potential (GWP) alternatives

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3️⃣ 8. Dongyue Group Limited

Headquarters: Zibo, Shandong, China
Key Offering: High-purity HFC-134a (HFA-134a)

Dongyue Group is a leading Chinese chemical company with a strong focus on the fluorosilicone industry. It is a key domestic producer of HFA-134a and is increasingly focusing on upgrading its processes to meet the stringent purity requirements of the pharmaceutical sector.

Key Initiatives & Capabilities:

• One of the largest fluorochemical production bases in China

• Strategic investments in R&D to improve product purity and yield

• Growing role in supplying the Asian pharmaceutical manufacturing hub

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2️⃣ 9. Mexichem S.A.B. de C.V. (Orbia)

Headquarters: Tlalnepantla, Mexico
Key Offering: Fluorinated compounds and specialty gases

Mexichem, now operating under the Orbia umbrella, has a strong presence in the fluorochemicals market in the Americas. The company produces a range of fluorinated products and has the infrastructure to cater to specialty gas markets, including pharmaceutical propellants.

Key Initiatives & Capabilities:

• Significant market presence in North and South America

• Integrated supply chain from fluorspar to finished fluorochemicals

• Focus on diversifying its product portfolio into high-value specialties

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1️⃣ 10. Sinochem Lantian Co., Ltd.

Headquarters: Hangzhou, Zhejiang, China
Key Offering: Refrigerants and fluorochemical intermediates

As part of the state-owned Sinochem Group, Sinochem Lantian is a significant player in China’s chemical industry. The company produces HFC-134a and is positioned to supply the domestic pharmaceutical market, contributing to regional supply chain resilience.

Key Initiatives & Capabilities:

• Backing of a major state-owned enterprise with substantial resources

• Focus on meeting China’s growing domestic demand for pharmaceutical ingredients

• Commitment to environmental protection and sustainable operations

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Pharmaceutical-grade HFA-134a Market – View in Detailed Research Report

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🌍 Outlook: The Future of Pharmaceutical-grade HFA-134a is Precision and Sustainability

The Pharmaceutical-grade HFA-134a market is evolving in response to both healthcare demands and environmental considerations. While HFA-134a remains the dominant propellant due to its proven safety and efficacy, the industry is actively exploring next-generation alternatives with improved environmental profiles.

📈 Key Trends Shaping the Market:

• Increasing global burden of respiratory diseases driving consistent MDI demand

• Stringent global regulatory harmonization for drug and excipient quality

• R&D into next-generation propellants with lower Global Warming Potential (GWP)

• Growth of contract manufacturing and outsourcing in pharmaceutical production

• Supply chain diversification and regionalization to enhance security of supply

Get Full Report Here:
Pharmaceutical-grade HFA-134a Market – View in Detailed Research Report

The companies profiled above are not just chemical suppliers; they are essential partners in global public health, ensuring that millions of patients worldwide have reliable access to life-saving inhalation therapies. Their commitment to quality, innovation, and supply chain excellence is fundamental to the future of respiratory care.