The Global Lyoprotectant Market was valued at USD 942.5 Million in 2025 and is projected to reach USD 1.58 Billion by 2034, growing at a Compound Annual Growth Rate (CAGR) of 5.9% during the forecast period. This robust growth is being driven by the expanding biopharmaceutical industry, increasing demand for stable biologics and vaccines, and continuous innovations in formulation science.

As the biopharmaceutical sector advances towards more complex therapeutics like monoclonal antibodies and mRNA vaccines, the role of lyoprotectants in ensuring product stability and efficacy has become paramount. In this blog, we profile the Top 10 Companies in the Lyoprotectant Industry—a mix of ingredient giants, specialized excipient suppliers, and innovative manufacturers shaping the future of biologics stabilization.

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🔟 1. Roquette

Headquarters: Lestrem, France
Key Offering: Pharmaceutical-grade Sugars (Mannitol, Sorbitol), Starches, and Custom Lyoprotectant Blends

Roquette is a global leader in plant-based ingredients and a premier supplier of pharmaceutical excipients. The company’s extensive portfolio includes high-purity sugars and polyols that are essential as lyoprotectants and bulking agents in lyophilized formulations. Roquette serves major pharmaceutical and biotech companies worldwide, providing critical excipients for injectables, vaccines, and biologic drugs.

Innovation Initiatives:

• Investment in R&D for novel carbohydrate-based stabilizers

• Development of multifunctional excipients for complex biologics

• Commitment to sustainable and traceable raw material sourcing

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Lyoprotectant Market – View in Detailed Research Report

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9️⃣ 2. Cargill

Headquarters: Wayzata, Minnesota, USA
Key Offering: Starches, Sweeteners (including Trehalose), Texturants, and Bioindustrial Products

Cargill’s Bioindustrial division provides essential ingredients for the pharmaceutical industry, including lyoprotectants derived from natural sources. Their product range supports the formulation of stable, lyophilized biologics, leveraging Cargill’s massive global agricultural supply chain to ensure consistent quality and supply.

Innovation Initiatives:

• Expansion of high-purity trehalose production capacity

• Collaborations with biopharma companies on formulation optimization

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8️⃣ 3. Ingredion

Headquarters: Westchester, Illinois, USA
Key Offering: Specialized Starches, Glucose Syrups, and High-Purity Carbohydrates

Ingredion is a leading global ingredient solutions provider with a strong focus on the pharmaceutical sector. The company offers a range of carbohydrate-based excipients that function as effective lyoprotectants, bulking agents, and stabilizers for freeze-dried products, catering to the stringent requirements of biologic drug manufacturers.

Innovation Initiatives:

• Development of clean-label, non-GMO starch derivatives

• Technical support for formulation development and scale-up

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7️⃣ 4. SPI Pharma

Headquarters: Wilmington, Delaware, USA
Key Offering: Highly Purified Mannitol, Custom Excipient Blends, and Contract Processing Services

SPI Pharma specializes in pharmaceutical excipients, with a particular focus on high-purity mannitol and other bulking agents critical for lyophilization. The company is renowned for its expertise in providing tailored solutions that meet the exacting standards of the global biopharmaceutical industry.

Innovation Initiatives:

• Proprietary Particle Engineering Technology for optimized excipient performance

• Focus on excipients for complex generics and biosimilars

Download FREE Sample Report:
Lyoprotectant Market – View in Detailed Research Report

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6️⃣ 5. Pharmacosmos

Headquarters: Holbaek, Denmark
Key Offering: High-Purity Iron Carbohydrates and Specialty Carbohydrates for Parenteral Applications

Pharmacosmos is a specialist in carbohydrates for pharmaceutical use, particularly known for its parenteral-grade iron products. The company also supplies high-quality carbohydrates that serve as lyoprotectants, leveraging deep expertise in the chemistry and application of sugars in sensitive biologic formulations.

Innovation Initiatives:

• Dedicated R&D in carbohydrate chemistry for advanced therapies

• Stringent quality control for injectable-grade excipients

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5️⃣ 6. EMD Millipore (Merck KGaA)

Headquarters: Darmstadt, Germany
Key Offering: BioReliance® Endotoxin-Tested Sugars, Process Solutions, and Analytical Services

EMD Millipore, a business of Merck KGaA, provides a comprehensive portfolio of products and services for the life science industry. Their offering includes high-purity, endotoxin-tested sugars and other excipients essential for the stabilization of biologics and vaccines during lyophilization, backed by extensive regulatory support.

Innovation Initiatives:

• Integrated solutions from development to commercial manufacturing

• Investment in single-use technologies and advanced analytics

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4️⃣ 7. BASF SE

Headquarters: Ludwigshafen, Germany
Key Offering: Kolliphor® and Kollicoat® Excipients, Polyvinylpyrrolidone (PVP), and Plasticizers

BASF’s Pharma Solutions business offers a wide range of excipients that can function as lyoprotectants and formulation aids. Their polymers, such as PVP, are used to stabilize proteins and other sensitive molecules during the freeze-drying process, preventing aggregation and denaturation.

Innovation Initiatives:

• Development of synthetic polymers for challenging biologic formulations

• Focus on enhancing solubility and stability of high-concentration protein drugs

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3️⃣ 8. Ashland Global Holdings Inc.

Headquarters: Wilmington, Delaware, USA
Key Offering: Benecel™ Hypromellose (HPMC), Klucel™ Hydroxypropylcellulose (HPC), and other Cellulose Derivatives

Ashland is a leading global supplier of specialty chemicals, including a broad range of pharmaceutical polymers. Their cellulose-based excipients are used as viscosity modifiers, stabilizers, and lyoprotectants in injectable and lyophilized drug products, providing critical protection for sensitive APIs.

Innovation Initiatives:

• Application expertise in formulation development for biologics

• Investment in sustainable and bio-based excipient platforms

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2️⃣ 9. DFE Pharma

Headquarters: Goch, Germany
Key Offering: Pharmacel® Microcrystalline Cellulose (MCC), Lactose, and other Functional Excipients

DFE Pharma is a leading expert in pharmaceutical excipients, offering products that are critical for creating stable lyophilized cakes. Their excipients ensure good cake structure, rapid reconstitution, and long-term stability, making them vital partners for drug manufacturers globally.

Innovation Initiatives:

• Specialization in excipients for inhalable and injectable products

• Development of co-processed excipients for optimized performance

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1️⃣ 10. JRS PHARMA

Headquarters: Rosenberg, Germany
Key Offering: Vivapur® Microcrystalline Cellulose, Prosolv® SMCC, and Specialty Excipients

JRS PHARMA is a globally recognized manufacturer of excipients derived from renewable raw materials. The company’s products are extensively used in solid dosage forms and lyophilized formulations, where they act as bulking agents and stabilizers, ensuring the quality and performance of the final drug product.

Innovation Initiatives:

• Focus on excipient functionality and performance enhancement

• Global technical support and custom solution development

Get Full Report Here:
Lyoprotectant Market – View in Detailed Research Report

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🧬 Outlook: The Future of Lyoprotectants Is Smarter and More Specialized

The lyoprotectant market is undergoing a significant transformation. While traditional sugars and polyols continue to dominate, the industry is investing heavily in advanced formulation science, novel excipient development, and customized solutions for next-generation therapies.

📈 Key Trends Shaping the Market:

• Rising demand for high-purity, animal-free, and defined-origin excipients

• Increasing complexity of biologic drugs requiring sophisticated stabilization strategies

• Growth in outsourcing to CROs/CMOs driving demand for standardized and ready-to-use lyoprotectant blends

• Regulatory emphasis on robust formulation data and Quality by Design (QbD) principles

Get Full Report Here:
Lyoprotectant Market – View in Detailed Research Report

The companies listed above are not only supplying critical excipients—they’re enabling the development and delivery of life-saving biologics and vaccines worldwide.