The Global Hyaluronic Acid (HA) Raw Material Market was valued at USD 1.15 Billion in 2025 and is projected to reach USD 2.03 Billion by 2034, growing at a Compound Annual Growth Rate (CAGR) of 6.5% during the forecast period (2026–2034). This significant growth is propelled by the booming aesthetics and cosmetics industries, expanding pharmaceutical applications in ophthalmology and orthopedics, and the rising consumer demand for nutraceuticals promoting joint and skin health.

As the healthcare and personal care sectors increasingly prioritize ingredients that offer advanced hydration, tissue repair, and biocompatibility, the focus shifts to the key producers who are driving innovation, scalability, and purity in HA production. In this blog, we profile the Top 10 Companies in the HA Raw Material Industry—a mix of biotechnology giants, fermentation specialists, and ingredient innovators shaping the future of this dynamic market.

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🔟 1. Bloomage Biotechnology Corporation Ltd.

Headquarters: Jinan, Shandong, China
Key Offering: Pharmaceutical Grade HA, Cosmetic Grade HA, Food Grade HA

Bloomage Biotechnology is the world’s largest producer of hyaluronic acid, commanding a significant share of the global market. The company operates state-of-the-art fermentation facilities and has a vertically integrated supply chain, from raw material sourcing to finished product distribution. Its extensive portfolio caters to a wide range of molecular weights and purity levels, serving major clients in the medical, cosmetic, and nutraceutical sectors worldwide.

Innovation and Expansion Initiatives:

• Continuous R&D in microbial fermentation technology for higher yields and purity

• Strategic global expansion and partnerships with international brands

• Investment in developing novel HA-based biomaterials for advanced drug delivery

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HA Raw Material Market – View in Detailed Research Report

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9️⃣ 2. Kewpie Corporation

Headquarters: Tokyo, Japan
Key Offering: High-Purity Pharmaceutical HA, HyaCare® Series (Cosmetic Grade)

Kewpie, a Japanese food and ingredient conglomerate, is a pioneer in hyaluronic acid production, initially discovering its extraction methods. Today, it is a leading global supplier, renowned for its exceptionally high-purity products. Kewpie’s HyaCare® series is a benchmark for quality in the cosmetic industry, while its pharmaceutical-grade HA is critical for ophthalmic surgeries and injectable treatments.

Innovation and Expansion Initiatives:

• Proprietary fermentation and purification processes ensuring ultra-low endotoxin levels

• Strong focus on regulatory compliance for medical applications (JP, USP, EP)

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8️⃣ 3. Contipro Group

Headquarters: Dolní Dobrouč, Czech Republic
Key Offering: High/Medium/Low Molecular Weight HA, ACP® (Acylated Hyaluronic Acid)

Contipro is a European leader specializing in the research, development, and manufacturing of high-value hyaluronic acid derivatives and fractions. The company is distinguished by its innovative ACP® technology, which enhances HA’s stability and skin affinity. Contipro focuses on advanced biomedical and cosmetic applications, providing tailored solutions for complex formulations.

Innovation and Expansion Initiatives:

• Pioneering research in cross-linked and modified HA for long-lasting effects

• Expansion of production capacities to meet growing European and North American demand

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7️⃣ 4. Shandong Focusfreda Biological Co., Ltd.

Headquarters: Jinan, Shandong, China
Key Offering: Cosmetic Grade HA, Pharmaceutical Grade HA, Oligo-HA

Shandong Focusfreda is a major Chinese manufacturer with a strong export footprint. The company produces a comprehensive range of hyaluronic acid products, with a particular strength in cosmetic-grade materials. Its focus on competitive pricing and consistent quality has made it a preferred supplier for many global cosmetic brands and contract manufacturers.

Innovation and Expansion Initiatives:

• Investment in automated production lines to enhance efficiency and scale

• Development of low molecular weight (Oligo-HA) for improved skin absorption

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HA Raw Material Market – View in Detailed Research Report

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6️⃣ 5. Givaudan Active Beauty

Headquarters: Vernier, Switzerland
Key Offering: Hyaskin™ (HA ingredients), PrimalHyal™ 50 (High Molecular Weight HA)

Givaudan, a global leader in flavors and fragrances, is a significant player in the beauty ingredients market through its Active Beauty division. The company offers a portfolio of patented HA ingredients, such as Hyaskin, which are designed for specific efficacy claims in skincare. Givaudan leverages its deep understanding of consumer trends to develop innovative HA solutions for its clients.

Innovation and Expansion Initiatives:

• Integration of HA into multifunctional active ingredient systems

• Focus on sustainable and natural-origin ingredients aligned with market trends

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5️⃣ 6. Fidia Farmaceutici S.p.A.

Headquarters: Abano Terme, Italy
Key Offering: HYAJECT® (for viscosupplementation), HA for Ophthalmology

Fidia Farmaceutici is a specialized pharmaceutical company with a long-standing heritage in hyaluronic acid-based therapeutics. It is a key supplier of medical-grade HA, particularly for the orthopedic market where its products are used in viscosupplementation for osteoarthritis. Fidia’s expertise lies in the stringent purification required for injectable medical devices.

Innovation and Expansion Initiatives:

• Leadership in developing HA-based medical devices for joint care

• Ongoing clinical research to expand therapeutic indications for HA

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4️⃣ 7. Seikagaku Corporation

Headquarters: Tokyo, Japan
Key Offering: Artz® (Arthritis Treatment), High-Purity HA for Research

Seikagaku Corporation is a Japanese biopharmaceutical company with a core focus on glycosaminoglycans, including hyaluronic acid. It is a leading provider of HA for therapeutic use, especially in orthopedics. The company also supplies high-purity HA for scientific research and diagnostic applications, underscoring its commitment to quality.

Innovation and Expansion Initiatives:

• Development of novel HA formulations with enhanced residence time in the joint

• Strategic focus on the regenerative medicine sector

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3️⃣ 8. Shandong AWA Biopharm Co., Ltd.

Headquarters: Liaocheng, Shandong, China
Key Offering: Cosmetic Grade HA, Food Grade HA, Pharmaceutical Intermediate HA

Shandong AWA Biopharm is an emerging yet significant manufacturer in the Chinese HA landscape. The company has been expanding its production capacity to capitalize on the growing global demand. It primarily serves the cosmetic and nutraceutical markets, offering cost-effective HA solutions without compromising on fundamental quality standards.

Innovation and Expansion Initiatives:

• Capacity expansion projects to increase market share

• Focus on streamlining production for competitive pricing

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2️⃣ 9. HTL Biotechnology

Headquarters: Javené, France
Key Offering: HYAJECT® (Non-Animal Stabilized Hyaluronic Acid), Javelle® HA

HTL Biotechnology is a French company specializing in the production of high-purity, non-animal derived hyaluronic acid. Its NASHA® technology platform is well-regarded for producing stable and biocompatible HA. The company supplies materials for aesthetic medicine, dermatology, and advanced therapies, with a strong emphasis on European regulatory standards.

Innovation and Expansion Initiatives:

• Expertise in bio-fermentation for animal-free, sustainable HA

• Partnerships with medical device companies for innovative applications

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1️⃣ 10. Singclean Medical Products Co., Ltd.

Headquarters: Hangzhou, Zhejiang, China
Key Offering: HA for Medical Devices, Dermal Fillers, Surgical Adjuvants

Singclean is a leading Chinese manufacturer of medical devices, including a range of products based on hyaluronic acid. While primarily an end-product manufacturer, its vertical integration and large-scale demand make it a significant consumer and processor of HA raw material. The company’s focus on affordable medical aesthetics products drives substantial volume requirements for high-quality HA.

Innovation and Expansion Initiatives:

• Vertical integration from raw material to finished medical devices

• Rapid expansion in domestic and international medical aesthetics markets

Get Full Report Here:
HA Raw Material Market – View in Detailed Research Report

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🔬 Outlook: The Future of HA Raw Material Is Specialized and Sustainable

The HA raw material market is undergoing a significant transformation. While the demand for standard grades continues to grow volumetrically, the industry’s value is increasingly shifting toward specialized, high-purity fractions, innovative derivatives, and sustainable production methods.

📈 Key Trends Shaping the Market:

• R&D into ultra-low molecular weight HA for enhanced bioactivity and penetration

• Growing consumer and regulatory preference for bio-fermented, animal-free HA sources

• Expansion of HA applications in regenerative medicine, wound care, and nutraceuticals

• Strategic consolidations and partnerships to secure supply chains and technological expertise

Get Full Report Here:
HA Raw Material Market – View in Detailed Research Report

The companies profiled above are not only supplying a critical global ingredient—they are at the forefront of scientific advancement in biotechnology and materials science, enabling healthier and more innovative products across multiple industries.