The Global Natural Angelica Extract Ligustilide Market was valued at USD 926 Million in 2025 and is projected to reach USD 1291 Million by 2034, growing at a Compound Annual Growth Rate (CAGR) of 5.0% during the forecast period (2025–2034). This robust growth trajectory is primarily driven by the escalating global consumer shift towards natural and herbal wellness solutions, increasing clinical validation of ligustilide’s therapeutic properties, and its expanding applications in pharmaceuticals, nutraceuticals, and the booming clean beauty sector.

As the demand for evidence-based botanical ingredients surges, the companies specializing in the extraction, purification, and distribution of high-purity ligustilide are positioned at the forefront of this market expansion. In this detailed analysis, we profile the Top 10 Companies in the Natural Angelica Extract Ligustilide Market—a diverse mix of specialized chemical suppliers, B2B ingredient providers, and R&D-focused firms that are standardizing and scaling the supply of this potent bioactive compound.

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🔟 1. BOC Sciences

Headquarters: Shirley, New York, USA
Key Offering: High-Purity Ligustilide (>98%), Custom Extraction Services

BOC Sciences is a leading global supplier of chemical products and services, including a comprehensive portfolio of high-purity natural extracts. The company is a significant player in the ligustilide market, offering standardized Angelica sinensis extracts that are critical for pharmaceutical R&D and nutraceutical manufacturing. Their expertise lies in managing complex supply chains to ensure consistent quality and purity for their global clientele.

Research & Development Initiatives:

• Investment in advanced analytical techniques (HPLC, GC-MS) for precise compound quantification

• Development of custom extraction protocols to meet specific client purity requirements

• Focus on scaling up production capabilities to meet rising industrial demand

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9️⃣ 2. Cayman Chemical

Headquarters: Ann Arbor, Michigan, USA
Key Offering: Analytical Standard Ligustilide, Research-Grade Extracts

Cayman Chemical is renowned for supplying high-quality biochemicals and assay kits to the global research community. Their role in the ligustilide market is pivotal for scientific validation, providing highly purified ligustilide standards that are essential for pharmacological studies, toxicity testing, and method development in academic and industrial laboratories.

Research & Development Initiatives:

• Provision of certified reference materials for quality control in manufacturing

• Support for preclinical research into ligustilide’s neuroprotective and anti-inflammatory mechanisms

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8️⃣ 3. TAUTO BIOTECH

Headquarters: Shanghai, China
Key Offering: Ligustilide Extracts (95%-98% Purity), Raw Angelica Powder

TAUTO BIOTECH leverages its strategic location in China, the primary source of Angelica sinensis, to provide cost-effective and authentic ligustilide extracts. The company specializes in serving the domestic Traditional Chinese Medicine (TCM) market as well as international clients, with a strong focus on sustainable sourcing and traditional extraction methods complemented by modern quality controls.

Research & Development Initiatives:

• Integration of traditional knowledge with modern phytochemical analysis

• Development of value-added Angelica-based formulations for specific health applications

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7️⃣ 4. NUONA TECHNOLOGY

Headquarters: Xi’an, Shaanxi, China
Key Offering: Ultra-Pure Ligustilide (>99%), Customized Phytochemical Solutions

NUONA TECHNOLOGY distinguishes itself through its technological prowess in supercritical fluid extraction and chromatography, enabling the production of some of the highest purity ligustilide available on the market. This makes them a preferred supplier for pharmaceutical companies requiring stringent specifications for drug development.

Research & Development Initiatives:

• Pioneering green extraction technologies to improve yield and reduce environmental impact

• Active collaboration with academic institutions on bioavailability enhancement studies

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Natural Angelica Extract Ligustilide Market – View in Detailed Research Report

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6️⃣ 5. ApexBio Technology

Headquarters: Taipei, Taiwan
Key Offering: Ligustilide for Biochemical Research, Inhibitor Screening

ApexBio Technology provides high-purity bioactive compounds, including ligustilide, primarily for life science research and drug discovery. Their products are essential tools for scientists exploring the molecular pathways and therapeutic potential of ligustilide, particularly in areas like neurology and oncology.

Research & Development Initiatives:

• Supplying labeled and modified ligustilide analogs for advanced mechanistic studies

• Supporting high-throughput screening campaigns for pharmaceutical partners

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5️⃣ 6. Pharmaffiliates

Headquarters: Punjab, India
Key Offering: Ligustilide Analytical Standards, Phytochemical Reference Materials

Pharmaffiliates is an emerging player with a strong focus on the quality control segment of the market. They supply certified reference standards of ligustilide, which are indispensable for manufacturers and regulatory bodies to verify the identity, purity, and potency of Angelica extract products, ensuring compliance with international pharmacopeia standards.

Research & Development Initiatives:

• Development of validated analytical methods for ligustilide quantification

• Expansion of their phytochemical library to support herbal drug standardization

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4️⃣ 7. EXTRASYNTHESE

Headquarters: Genay, France
Key Offering: High-Purity Natural Product Standards, Including Ligustilide

EXTRASYNTHESE is a European specialist in the synthesis and purification of natural compounds. They cater to a sophisticated market demand for highly characterized ligustilide, serving both the research community and quality control laboratories in the cosmetic and pharmaceutical industries across Europe and North America.

Research & Development Initiatives:

• Expertise in the synthesis of rare phthalide derivatives for comparative studies

• Focus on stability testing and degradation profiling of ligustilide

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3️⃣ 8. ChemScence

Headquarters: Monmouth Junction, New Jersey, USA
Key Offering: Ligustilide for Research, Building Blocks for Synthesis

ChemScence operates as a critical link in the supply chain for research institutions and small to medium-sized enterprises (SMEs) in the nutraceutical space. They provide reliable access to ligustilide, facilitating early-stage product development and academic research outside of large-scale industrial procurement.

Research & Development Initiatives:

• Providing gram to kilogram quantities for pilot-scale projects

• Supporting innovation in dietary supplement formulations

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2️⃣ 9. Hairui Chemical

Headquarters: Zhengzhou, Henan, China
Key Offering: Ligustilide, Angelica Extract Powder, Custom Manufacturing

Hairui Chemical is a versatile manufacturer with a broad catalog of fine chemicals and plant extracts. Their strength in the ligustilide market lies in their competitive pricing and scalability, making natural Angelica extract accessible for a wider range of applications, including cost-sensitive segments of the nutraceutical and cosmetic industries.

Research & Development Initiatives:

• Optimization of extraction processes to balance cost with purity

• Expansion of Good Manufacturing Practice (GMP) compliant production lines

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1️⃣ 10. Other Emerging & Regional Players

Headquarters: Various (Global)
Key Offering: Niche Ligustilide Products, Regional Specialties

Beyond the major players, the market includes a dynamic ecosystem of smaller biotechnology firms, regional suppliers, and startups. These entities often focus on specific niches, such as organic-certified extracts, vertically integrated supply chains from farm to extract, or novel delivery systems for ligustilide (e.g., liposomal formulations). They are crucial for driving innovation, catering to localized demand, and increasing market penetration in emerging economies.

Innovation Initiatives:

• Development of proprietary extraction technologies

• Focus on sustainable and traceable sourcing of Angelica sinensis

• Creation of value-added finished products for direct consumer markets

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Natural Angelica Extract Ligustilide Market – View in Detailed Research Report

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🌍 Outlook: The Future of Natural Angelica Extract Ligustilide Is Precision and Personalization

The Natural Angelica Extract Ligustilide market is at a pivotal juncture. While traditional herbal use provides a stable foundation, the future is being shaped by scientific innovation, precision extraction, and personalized health applications. The convergence of ancient wisdom with modern technology is unlocking unprecedented opportunities for growth and therapeutic advancement.

📈 Key Trends Shaping the Market:

• Precision Extraction and Standardization: Advancements in purification technologies are enabling the production of ligustilide with consistent and high (>98%) purity, which is essential for pharmaceutical applications and reproducible health outcomes.

• Expansion into Cosmeceuticals: The anti-inflammatory and antioxidant properties of ligustilide are being harnessed in high-end skincare products, aligning with the global clean beauty trend and driving demand from cosmetic manufacturers.

• Clinical Validation and New Indications: Ongoing research is expanding the potential applications of ligustilide beyond women’s health into neuroprotection, cardiovascular wellness, and metabolic health, opening new multi-billion dollar market segments.

• Sustainable and Transparent Sourcing: Consumer and regulatory pressure is pushing companies to adopt sustainable agricultural practices for Angelica sinensis cultivation and provide full traceability from farm to final product.

Get Full Report Here:
Natural Angelica Extract Ligustilide Market – View in Detailed Research Report

The companies profiled are not merely suppliers of a botanical extract—they are enablers of a health and wellness revolution, bridging the gap between traditional herbal medicine and the evidentiary standards of modern science.

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