The Global Polymyxin API Market was valued at USD 318.9 Million in 2023 and is projected to reach USD 485.2 Million by 2030, growing at a Compound Annual Growth Rate (CAGR) of 6.2% during the forecast period (2024–2030). This significant growth is primarily driven by the escalating global threat of antimicrobial resistance (AMR), particularly from multidrug-resistant Gram-negative bacteria, and the critical role of polymyxins as a last-resort treatment option.

As healthcare systems worldwide grapple with the challenge of superbugs, the pharmaceutical companies manufacturing the active pharmaceutical ingredients (APIs) for polymyxin-based drugs are at the forefront of this essential battle. In this blog, we profile the Top 10 Companies in the Polymyxin API Industry—a collection of specialized pharmaceutical manufacturers and suppliers ensuring the global supply of these life-saving antibiotics.

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🔟 1. Xellia Pharmaceuticals ApS

Headquarters: Copenhagen, Denmark
Key Offering: Colistimethate Sodium (Polymyxin E), Polymyxin B Sulfate

Xellia Pharmaceuticals is a global leader in anti-infectives, specializing in the development and manufacturing of APIs for resistant bacterial and fungal infections. With a strong heritage and a dedicated focus on niche antibiotics, Xellia is a cornerstone supplier of high-quality Polymyxin APIs to the global pharmaceutical market.

Key Strategic Initiatives:

• Investment in advanced fermentation and purification technologies for enhanced API yield and purity.

• Strategic focus on securing and stabilizing the supply chain for last-resort antibiotics.

• Commitment to rigorous quality control standards compliant with major international pharmacopoeias (USP, EP).

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9️⃣ 2. Livzon Pharmaceutical Group

Headquarters: Zhuhai, Guangdong, China
Key Offering: Polymyxin B Sulfate API, Colistin Sulfate API

Livzon Pharmaceutical Group is one of China’s leading pharmaceutical manufacturers with a significant presence in the API sector. The company has robust manufacturing capabilities for polymyxin APIs and supplies both the domestic Chinese market and international clients, playing a vital role in the Asian antibiotic supply chain.

Key Strategic Initiatives:

• Expansion of API production capacity to meet growing domestic and international demand.

• Active pursuit of international regulatory approvals to expand its global market footprint.

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8️⃣ 3. Shenzhen Polymax Biotech Co., Ltd.

Headquarters: Shenzhen, Guangdong, China
Key Offering: Colistin Sulfate, Polymyxin B Sulfate

Shenzhen Polymax Biotech is a specialized manufacturer of peptide antibiotics, with polymyxins being a core part of its product portfolio. The company focuses on research, development, and production of high-purity APIs for the pharmaceutical industry.

Key Strategic Initiatives:

• Specialization in the fermentation process optimization for polymyxin production.

• Development of stringent quality assurance protocols to ensure batch-to-batch consistency.

Download FREE Sample Report:
Global Polymyxin API Market – View in Detailed Research Report

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7️⃣ 4. Fengchen Group Co., Ltd.

Headquarters: Shanghai, China
Key Offering: Polymyxin B Sulfate, Colistin Sulfate for pharmaceutical use

Fengchen Group is a diversified chemical and pharmaceutical supplier with a significant API business. The company supplies Polymyxin APIs to formulation manufacturers and is known for its competitive pricing and large-scale production capabilities.

Key Strategic Initiatives:

• Leveraging economies of scale to maintain a competitive position in the global market.

• Continuous improvement of manufacturing processes to reduce environmental impact and enhance efficiency.

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6️⃣ 5. Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

Headquarters: Hangzhou, Zhejiang, China
Key Offering: Colistimethate Sodium, Polymyxin B API

As a subsidiary of the larger Huadong Medicine group, this company has strong R&D and manufacturing capabilities in the antibiotic sector. It is a reputable supplier of polymyxin APIs, with a focus on meeting the stringent requirements of regulated markets.

Key Strategic Initiatives:

• Investment in R&D for improving the stability and solubility profiles of polymyxin APIs.

• Building long-term partnerships with global pharmaceutical companies for API supply.

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5️⃣ 6. Midas Pharma GmbH

Headquarters: Ingelheim, Germany
Key Offering: Polymyxin B Sulfate, Colistimethate Sodium

Midas Pharma is a European pharmaceutical company specializing in the development, registration, and distribution of APIs and finished dosage forms. It acts as a key intermediary, sourcing and supplying high-quality Polymyxin APIs to pharmaceutical manufacturers across Europe and other regions.

Key Strategic Initiatives:

• Providing comprehensive regulatory support for market authorization in Europe.

• Ensuring a reliable and audited supply chain for critical medicines.

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4️⃣ 7. LGM Pharma

Headquarters: Boca Raton, Florida, USA
Key Offering: Polymyxin B Sulfate API, Colistin Sulfate

LGM Pharma is a leading global API supplier and distributor, providing comprehensive services from sourcing and qualification to regulatory support. The company offers Polymyxin APIs to generic and innovator pharmaceutical companies, particularly focusing on the North American market.

Key Strategic Initiatives:

• Robust quality management system ensuring cGMP compliance for all supplied APIs.

• Strategic logistics network to ensure timely delivery of critical pharmaceutical ingredients.

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3️⃣ 8. Caesar & Loretz GmbH

Headquarters: Hilden, Germany
Key Offering: Polymyxin B Sulfate

Caesar & Loretz (Caelo) is a well-established German supplier of pharmaceutical ingredients, excipients, and finished dosage forms. The company supplies high-quality Polymyxin B Sulfate to the pharmaceutical industry, backed by strong technical and regulatory expertise.

Key Strategic Initiatives:

• Focus on sourcing APIs from qualified and audited manufacturers.

• Providing tailored solutions and support for pharmaceutical development projects.

Download FREE Sample Report:
Global Polymyxin API Market – View in Detailed Research Report

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2️⃣ 9. Yancheng Youhua Pharma and Chemical Co., Ltd.

Headquarters: Yancheng, Jiangsu, China
Key Offering: Colistin Sulfate, Polymyxin Sulfate

Yancheng Youhua is a Chinese manufacturer with a focus on pharmaceutical intermediates and APIs. The company produces polymyxin APIs and supplies them to both domestic formulators and international markets, contributing significantly to the global supply volume.

Key Strategic Initiatives:

• Cost-effective manufacturing processes to compete in the global API market.

• Efforts to upgrade facilities to meet international regulatory standards.

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1️⃣ 10. Lianyungang Runzhong Pharmaceutical Co., Ltd.

Headquarters: Lianyungang, Jiangsu, China
Key Offering: Polymyxin E (Colistin) API

Lianyungang Runzhong Pharmaceutical is a specialized producer of pharmaceutical ingredients, including polymyxins. The company plays a role in the supply chain for these critical antibiotics, particularly serving the Asian pharmaceutical manufacturing base.

Key Strategic Initiatives:

• Focus on production efficiency and scaling up to meet market demands.

• Engagement in the development of pharmaceutical-grade intermediates.

Read Full Report:
Global Polymyxin API Market – View in Detailed Research Report

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🌍 Outlook: The Future of Polymyxin APIs in an Era of Antimicrobial Resistance

The Polymyxin API market is defined by its critical role in public health. While these antibiotics have been available for decades, their importance has been magnified by the rise of untreatable infections. The market’s evolution is now shaped by the need for supply chain resilience, stringent quality control, and responsible use to preserve their efficacy.

📈 Key Trends Shaping the Market:

• Increased Regulatory Scrutiny: Regulatory agencies like the FDA and EMA are imposing stricter controls on manufacturing quality and promoting antimicrobial stewardship to combat resistance.

• Geopolitical Influences on Supply Chains: The concentration of API production in specific regions highlights the need for diversified and secure supply sources to prevent shortages.

• Research into Next-Generation Polymyxins: Efforts are underway to develop novel polymyxin analogs with improved safety profiles and activity against resistant strains.

• Growing Emphasis on Combination Therapies: Polymyxins are increasingly used in combination with other antibiotics to enhance efficacy and slow resistance development, influencing API demand.

Read Full Report:
Global Polymyxin API Market – View in Detailed Research Report

The companies listed above are not just suppliers of chemical compounds; they are essential partners in the global healthcare infrastructure, providing the last line of defense against some of the world’s most dangerous bacterial infections.