The Global Nicotinamide Riboside Hydrogen Malate (NR-HM) Market was valued at USD 19.8 Million in 2025 and is projected to reach USD 30.5 Million by 2034, growing at a Compound Annual Growth Rate (CAGR) of 4.7% during the forecast period (2024–2034). This robust growth is being driven by rising consumer awareness of cellular health, increasing demand for anti-aging and longevity supplements, and the critical role of Nicotinamide Adenine Dinucleotide (NAD+) precursors in metabolic function and disease prevention.

As the nutraceutical and pharmaceutical industries shift their focus toward solutions that target the root causes of aging and metabolic dysfunction, the spotlight is on the key ingredient manufacturers driving innovation, purity, and scientific validation. In this blog, we profile the Top 10 Companies in the Nicotinamide Riboside Hydrogen Malate (NR-HM) Industry—a mix of pioneering biotech firms and established ingredient suppliers shaping the future of cellular health supplementation.

---

🔟 1. Bontac Bio-Engineering (Shenzhen) Co., Ltd.

Headquarters: Shenzhen, Guangdong, China
Key Offering: High-Purity NR-HM (>99.5%), Enzymatic Catalysis Technology

Bontac Bio-Engineering is a leading global player in the synthesis of NAD+ precursors, including Nicotinamide Riboside (NR) and its stable salt form, NR-HM. The company leverages advanced enzymatic synthesis platforms to produce high-purity ingredients for the nutraceutical and pharmaceutical markets.

Key Innovations:

• Proprietary enzymatic manufacturing process ensuring high yield and purity

• Strong R&D focus on NAD+ biology and related coenzymes

• Strategic partnerships with global supplement brands

Download FREE Sample Report:
Nicotinamide Riboside Hydrogen Malate (NR-HM) Market – View in Detailed Research Report

---

9️⃣ 2. Invertin Biotech

Headquarters: Goa, India
Key Offering: NR-HM, Custom Fermentation Services

Invertin Biotech specializes in the fermentation-based production of high-value nutraceutical ingredients. Their NR-HM is known for its consistency and scalability, catering to both bulk ingredient buyers and finished product manufacturers seeking reliable supply chains.

Key Innovations:

• Fermentation technology for sustainable and cost-effective production

• Focus on green chemistry and reduced environmental impact

---

8️⃣ 3. Bicells Science Ltd.

Headquarters: Wuhan, Hubei, China
Key Offering: Pharmaceutical-Grade NR-HM, Research Chemicals

Bicells Science Ltd. is a research-driven company supplying high-purity biochemicals to the pharmaceutical and life sciences industries. Their NR-HM is manufactured under strict quality control protocols, making it suitable for clinical research and premium supplement formulations.

Key Innovations:

• cGMP compliant manufacturing facilities

• Specialization in nucleotides and nucleosides for research applications

---

7️⃣ 4. SENTIANBIO

Headquarters: Suzhou, Jiangsu, China
Key Offering: NR-HM, NMN, Custom Synthesis

SENTIANBIO is a prominent manufacturer of longevity-related ingredients, with a strong portfolio that includes Nicotinamide Mononucleotide (NMN) and NR-HM. The company focuses on integrating R&D with manufacturing to deliver high-quality, scientifically-backed raw materials.

Key Innovations:

• Integrated R&D and production capabilities

• Commitment to quality and third-party testing verification

---

6️⃣ 5. Wuxi Vega Science Co., Ltd.

Headquarters: Wuxi, Jiangsu, China
Key Offering: NR-HM, Cosmetic & Nutraceutical Ingredients

Wuxi Vega Science supplies a wide range of bioactive ingredients for the health, personal care, and food industries. Their NR-HM is utilized in formulations targeting skin health from within, leveraging its role in cellular energy and repair.

Key Innovations:

• Application development support for formulators

• Focus on ingredient stability and bioavailability

Download FREE Sample Report:
Nicotinamide Riboside Hydrogen Malate (NR-HM) Market – View in Detailed Research Report

---

5️⃣ 6. Botanical Cube Inc.

Headquarters: Xi’an, Shaanxi, China
Key Offering: NR-HM, Plant Extracts, Herbal Ingredients

Botanical Cube Inc. combines expertise in botanical extracts with modern synthetic biology to offer a diverse portfolio of health ingredients. Their foray into NR-HM demonstrates their commitment to providing cutting-edge, science-based solutions to the global market.

Key Innovations:

• Synergy between botanical and synthetic ingredient expertise

• Strong global distribution network

---

4️⃣ 7. Xi’an Prius Biological Engineering Co., Ltd

Headquarters: Xi’an, Shaanxi, China
Key Offering: NR-HM, Amino Acids, Peptides

Xi’an Prius Biological Engineering is a established manufacturer of fine chemicals and biological products. The company produces NR-HM alongside a range of other health-promoting compounds, leveraging its expertise in purification and quality control.

Key Innovations:

• Advanced purification technologies for high-purity outputs

• Experience in serving regulated markets worldwide

---

3️⃣ 8. TianMingPharm

Headquarters: Shanghai, China
Key Offering: Pharmaceutical Intermediates, NR-HM

TianMingPharm operates at the intersection of pharmaceuticals and nutraceuticals, producing high-quality intermediates like NR-HM. Their focus on pharmaceutical standards ensures their ingredients meet stringent quality requirements.

Key Innovations:

• Production adhering to pharmaceutical industry standards

• Strategic focus on intermediates for active pharmaceutical ingredients (APIs)

---

2️⃣ 9. Innova GreenTech Inc.

Headquarters: Nanjing, Jiangsu, China
Key Offering: NR-HM, Green Synthesis Technologies

Innova GreenTech Inc. is dedicated to developing environmentally friendly manufacturing processes for bioactive molecules. Their production of NR-HM emphasizes sustainability without compromising on purity or efficacy.

Key Innovations:

• Development of green chemistry synthesis routes

• Commitment to reducing the ecological footprint of chemical production

---

1️⃣ 10. Hygieia Biotech

Headquarters: Guangzhou, Guangdong, China
Key Offering: NR-HM, Probiotics, Synbiotic Formulations

Hygieia Biotech specializes in innovative health solutions, combining ingredients like NR-HM with probiotics to create synergistic formulations for gut health and overall well-being. They serve brands looking for scientifically-advanced, multi-mechanism products.

Key Innovations:

• Research into the gut-NAD+ axis and microbiome health

• Development of combination products for enhanced efficacy

Get Full Report Here:
Nicotinamide Riboside Hydrogen Malate (NR-HM) Market – View in Detailed Research Report

---

🔬 Outlook: The Future of NR-HM Is Rooted in Science and Accessibility

The Nicotinamide Riboside Hydrogen Malate market is experiencing a significant transformation. While foundational research on NAD+ boosting continues to advance, the industry is investing in cleaner production methods, clinical validation, and broader application development beyond traditional supplements.

📈 Key Trends Shaping the Market:

• Increasing clinical research validating the health benefits of NR and its salts

• Growing consumer demand for scientifically-backed longevity ingredients

• Expansion into new applications, including functional foods, beverages, and topical cosmetics

• Regulatory advancements, such as FDA’s New Dietary Ingredient (NDI) status for NR-HM in the U.S., paving the way for market growth

Get Full Report Here:
Nicotinamide Riboside Hydrogen Malate (NR-HM) Market – View in Detailed Research Report

The companies listed above are not only supplying a critical health ingredient—they’re pioneering the science of healthy aging for a global population.