The Global HA Raw Material Market was valued at USD 1.72 Billion in 2025 and is projected to reach USD 2.87 Billion by 2034, growing at a Compound Annual Growth Rate (CAGR) of 6.9% during the forecast period (2024–2030). This robust growth is primarily driven by the expanding applications of hyaluronic acid in medical aesthetics, pharmaceuticals, and advanced cosmetics, alongside increasing consumer demand for anti-aging and wellness products.

As the medical and personal care industries increasingly rely on high-purity, bio-compatible ingredients, the spotlight is on the key raw material producers driving innovation, quality, and supply chain resilience. In this blog, we profile the Top 10 Companies in the HA Raw Material Industry—a combination of established biochemical giants and specialized biotech firms shaping the future of hyaluronic acid supply.

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🔟 1. Bloomage Biotechnology

Headquarters: Jinan, Shandong, China
Key Offering: High & Low Molecular Weight HA, Cross-linked HA, Oligo-HA

Bloomage Biotechnology is the world’s largest producer of hyaluronic acid, holding a significant global market share. The company supplies pharmaceutical-grade, cosmetic-grade, and food-grade HA to a vast network of clients worldwide, supported by extensive R&D capabilities and large-scale fermentation technology.

Innovation Focus:

• Pioneering microbial fermentation for high-purity HA production

• Development of novel HA derivatives for targeted drug delivery

• Strategic expansion into regenerative medicine applications

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9️⃣ 2. Kewpie Corporation

Headquarters: Tokyo, Japan
Key Offering: Hyaluronan, HA-based Functional Ingredients

Kewpie, a leading Japanese food and ingredient company, is a major player in the HA market with a strong focus on quality and safety. Its hyaluronic acid is widely used in dietary supplements, functional foods, and high-end cosmetic formulations, leveraging decades of expertise in bio-fermentation.

Innovation Focus:

• Leading research into oral bioavailability of HA for nutraceuticals

• Focus on sustainable and traceable raw material sourcing

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8️⃣ 3. Contipro a.s.

Headquarters: Dolní Dobrouč, Czech Republic
Key Offering: HA Derivatives, Modified HA, Ultra-High Molecular Weight HA

Contipro is a prominent European manufacturer known for its innovative HA derivatives and proprietary production processes. The company specializes in high-value, modified hyaluronic acid for advanced medical devices, ophthalmology, and sophisticated cosmetic applications.

Innovation Focus:

• Expertise in chemical modification of HA for enhanced functionality

• Development of HA-based biomaterials for tissue engineering

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7️⃣ 4. Givaudan Active Beauty

Headquarters: Vernier, Switzerland
Key Offering: Hyaluronic Acid, Hyaluronic Acid Precursors, Skincare Actives

Givaudan, a global leader in flavors and fragrances, is a key supplier of high-quality HA through its Active Beauty division. The company integrates HA into comprehensive active ingredient solutions for the global cosmetics industry, emphasizing performance and sensorial benefits.

Innovation Focus:

• Development of multi-functional HA complexes for skincare

• Focus on sustainable biotechnology and green chemistry principles

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6️⃣ 5. Shandong Focusfreda Biological Co., Ltd.

Headquarters: Jinan, Shandong, China
Key Offering: Pharmaceutical Grade HA, Cosmetic Grade HA, HA Sodium Salt

Shandong Focusfreda is a major Chinese manufacturer with a strong export focus. The company produces a wide range of hyaluronic acid products, serving both domestic and international markets with competitive pricing and consistent quality, supported by large production capacities.

Innovation Focus:

• Continuous optimization of fermentation yield and efficiency

• Expansion of product portfolio to include specialized HA grades

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5️⃣ 6. FNF (Neimenggu Fufeng Biotechnologies Co., Ltd.)

Headquarters: Hohhot, Inner Mongolia, China
Key Offering: Hyaluronic Acid, Microbial Polysaccharides

Fufeng Biotechnologies leverages its expertise in large-scale fermentation to produce hyaluronic acid as part of its broad portfolio of bio-products. The company is a significant volume supplier, catering to the cost-sensitive segments of the cosmetics and nutraceutical markets.

Innovation Focus:

• Integration of HA production with other fermentation-based products

• Focus on scalable and cost-effective manufacturing processes

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4️⃣ 7. Eastar Holdings Group Co., Ltd.

Headquarters: Hangzhou, Zhejiang, China
Key Offering: Hyaluronic Acid, Chondroitin Sulfate, Other Glycosaminoglycans

Eastar Holdings is a specialized manufacturer of natural ingredients, including hyaluronic acid and other bioactive compounds. The company has built a reputation for reliability and serves a diverse clientele in the pharmaceutical, cosmetic, and healthcare industries.

Innovation Focus:

• Development of combination products with synergistic ingredients

• Investment in R&D for novel extraction and purification technologies

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3️⃣ 8. Shandong Awa Biopharm Co., Ltd.

Headquarters: Linyi, Shandong, China
Key Offering: HA Raw Materials, Heparin Sodium, Chondroitin Sulfate

Shandong Awa Biopharm specializes in the production of animal-derived and fermentation-based bioactive ingredients. The company is a growing player in the HA market, focusing on expanding its production capacity and quality control systems to meet international standards.

Innovation Focus:

• Diversification of sourcing and production methods for HA

• Strengthening regulatory compliance for global market access

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2️⃣ 9. HAIKE GROUP (Shandong)

Headquarters: Jinan, Shandong, China
Key Offering: Hyaluronic Acid, Cosmetic Active Ingredients

Haike Group is an integrated biochemical company with a significant presence in the hyaluronic acid market. The company controls its supply chain from raw materials to finished products, offering a vertically integrated solution for its customers.

Innovation Focus:

• Vertical integration for cost control and supply security

• Development of customized HA solutions for specific applications

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1️⃣ 10. Seikagaku Corporation

Headquarters: Tokyo, Japan
Key Offering: High-Purity Hyaluronic Acid, Glycosaminoglycan Research Products

Seikagaku Corporation is a Japanese biopharmaceutical company with a long history of expertise in glycosaminoglycan research, including hyaluronic acid. The company is renowned for its ultra-high-purity HA, which is critical for pharmaceutical and research applications, particularly in ophthalmology and orthopedics.

Innovation Focus:

• Leading-edge research on HA structure-function relationships

• Development of HA-based therapeutics for medical use

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🌍 Outlook: The Future of HA Raw Materials Is High-Tech and Application-Specific

The HA raw material market is undergoing a significant transformation. While standard-grade HA remains a volume driver, the industry is increasingly focused on high-value, specialized derivatives, advanced purification technologies, and sustainable production methods.

📈 Key Trends Shaping the Market:

• Rising demand for ultra-low molecular weight HA for enhanced skin penetration

• Growing adoption of HA in regenerative medicine and drug delivery systems

• Increasing regulatory scrutiny and quality standards for pharmaceutical-grade HA

• Shift towards bio-fermentation over animal-derived extraction for sustainability and purity

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The companies listed above are not only supplying a vital biomaterial—they are enabling advancements in healthcare, beauty, and wellness across the globe.

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