The Global Histidine Market was valued at USD 230 Million in 2024 and is projected to reach USD 349 Million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 6.3% during the forecast period (2025–2032). This growth is being driven by rising demand from pharmaceutical applications, expanding animal feed industries, and the accelerating adoption of sustainable fermentation technologies across nutraceutical and food supplement sectors.

As the health and nutrition industry prioritizes protein fortification and specialized amino acid formulations, the spotlight is on the key producers who are driving innovation, quality, and production efficiency. In this blog, we profile the Top 10 Companies in the Histidine Industry—a mix of established bio-pharmaceutical giants, fermentation specialists, and regional leaders shaping the future of amino acid supply.

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🔟 1. Kyowa Hakko Bio

Headquarters: Tokyo, Japan
Key Offering: Pharmaceutical-Grade L-Histidine, Feed-Grade Histidine

Kyowa Hakko Bio is a global leader in amino acid production, renowned for its advanced fermentation technologies and high-purity histidine. The company supplies critical ingredients to major pharmaceutical companies worldwide and holds a dominant position in the Asian market. Their R&D focus is on improving yield efficiency and developing novel histidine applications in therapeutics.

Innovation Initiatives:

• Pioneering microbial fermentation processes for amino acids

• Strategic partnerships with global pharmaceutical corporations

• Commitment to sustainable bio-production methods

Download FREE Sample Report: Histidine Market – View in Detailed Research Report

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9️⃣ 2. Ajinomoto Co., Inc.

Headquarters: Tokyo, Japan
Key Offering: Ajinomoto Brand L-Histidine, Custom Amino Acid Blends

Ajinomoto is one of the world’s largest amino acid producers, with histidine being a key product in their extensive portfolio. The company’s vertically integrated operations span from raw material sourcing to finished product distribution, ensuring consistent quality and supply chain reliability for customers in over 130 countries.

Innovation Initiatives:

• Expanding production capacity for pharmaceutical-grade amino acids

• Developing specialized histidine formulations for clinical nutrition

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8️⃣ 3. Evonik Industries AG

Headquarters: Essen, Germany
Key Offering: Pharmaceutical Excipients, Animal Nutrition Amino Acids

Evonik’s Health & Nutrition division is a significant player in the European histidine market, particularly for pharmaceutical applications. The company’s strong technical expertise in amino acid chemistry and regulatory compliance makes it a preferred supplier for regulated markets.

Innovation Initiatives:

• Focus on cGMP-compliant manufacturing facilities

• Research into histidine’s role in advanced drug delivery systems

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7️⃣ 4. SHOWA DENKO K.K. (Now Resonac Holdings)

Headquarters: Tokyo, Japan
Key Offering: High-Purity L-Histidine, Electronic Grade Amino Acids

As part of Resonac Holdings, the company maintains strong capabilities in specialty chemical production, including pharmaceutical-grade histidine. Their focus on ultra-high purity products positions them well in premium market segments requiring stringent quality standards.

Innovation Initiatives:

• Investment in continuous fermentation process optimization

• Development of specialty histidine derivatives for niche applications

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6️⃣ 5. Merck KGaA

Headquarters: Darmstadt, Germany
Key Offering: MilliporeSigma Brand Histidine, Life Science Reagents

Merck’s life science business offers high-purity histidine primarily for research, pharmaceutical development, and bioprocessing applications. Their products are essential components in cell culture media, buffer systems, and various biopharmaceutical formulations.

Innovation Initiatives:

• Extensive quality control and documentation for regulatory submissions

• Collaboration with biotech companies on novel therapeutic applications

Download FREE Sample Report: Histidine Market – View in Detailed Research Report

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5️⃣ 6. Shine Star Biological Engineering Co., Ltd.

Headquarters: Hubei, China
Key Offering: Feed-Grade Histidine, Food Additive Grade Amino Acids

As one of China’s leading amino acid producers, Shine Star has significantly expanded its histidine production capacity to meet growing domestic and international demand. The company competes effectively in price-sensitive markets while maintaining consistent quality standards.

Innovation Initiatives:

• Cost-optimized production processes for competitive pricing

• Expansion into pharmaceutical-grade amino acid production

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4️⃣ 7. KingYork Group

Headquarters: Shandong, China
Key Offering: Industrial Grade Histidine, Animal Feed Additives

KingYork has established itself as a reliable supplier of histidine for animal nutrition applications, particularly in the rapidly growing Asian livestock sector. The company’s strategic location in a major agricultural region provides advantages in raw material sourcing and logistics.

Innovation Initiatives:

• Development of customized amino acid blends for specific animal species

• Investment in environmental sustainability for production facilities

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3️⃣ 8. Jiangsu Sainty Group

Headquarters: Jiangsu, China
Key Offering: Pharmaceutical Intermediates, Bulk Amino Acids

Jiangsu Sainty Group has diversified into amino acid production, including histidine, leveraging its established chemical manufacturing infrastructure. The company serves both domestic Chinese markets and international customers seeking cost-effective alternatives.

Innovation Initiatives:

• Vertical integration to control production costs

• Focus on meeting international quality standards for export markets

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2️⃣ 9. Huaheng Biological Technology Co., Ltd.

Headquarters: Shandong, China
Key Offering: L-Histidine, Amino Acid Fertilizers, Feed Additives

Huaheng Biological specializes in fermentation-based production of amino acids, with growing capabilities in histidine manufacturing. The company’s focus on biological technologies positions it well for the industry’s shift toward sustainable production methods.

Innovation Initiatives:

• Adoption of green chemistry principles in manufacturing

• Research into agricultural applications of amino acids

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1️⃣ 10. Bafeng Pharmaceutical & Chemical Co., Ltd.

Headquarters: Hebei, China
Key Offering: Pharmaceutical Raw Materials, Amino Acid Salts

Bafeng Pharmaceutical has expanded from traditional chemical production into amino acids, including histidine for pharmaceutical applications. The company benefits from China’s strong chemical industry infrastructure and growing technical expertise in fine chemical manufacturing.

Innovation Initiatives:

• Development of histidine salts for improved stability in formulations

• Investment in analytical capabilities for quality assurance

Get Full Report Here: Histidine Market – View in Detailed Research Report

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🌍 Outlook: The Future of Histidine Is Precision and Sustainability

The histidine market is undergoing a significant transformation. While traditional applications in animal feed and basic pharmaceuticals continue to drive volume, the industry is increasingly focused on high-value specialty applications, precision nutrition, and sustainable production technologies.

📈 Key Trends Shaping the Market:

• R&D expansion in fermentation efficiency and yield optimization

• Growing regulatory emphasis on amino acid purity and safety standards

• Increasing integration of histidine in personalized nutrition and therapeutics

• Strategic alliances between amino acid producers and end-user industries

Get Full Report Here: Histidine Market – View in Detailed Research Report

The companies listed above are not only supplying essential nutrients—they’re driving the innovation and sustainability that will define the future of health and nutrition markets globally.