The Global Silk Fibroin Powder Market was valued at USD 115 Million in 2025 and is projected to reach USD 261 Million by 2034, growing at a Compound Annual Growth Rate (CAGR) of 12.5% during the forecast period (2026–2034). In 2024, global consumption reached approximately 1,008 tons, with an average market price of around 124.6 USD/kg. This remarkable growth is fueled by the escalating demand for natural, biocompatible, and high-performance materials across biomedical, cosmetics, and advanced materials sectors, driven by consumer preference for sustainable and effective ingredients.

As industries pivot towards bio-based solutions, the focus intensifies on the key manufacturers and innovators who are unlocking the potential of this ancient, yet remarkably advanced, natural protein. In this blog, we profile the Top 10 Companies in the Silk Fibroin Powder Industry—a diverse mix of established biochemical firms, specialized biotech startups, and research-driven enterprises shaping the future of this high-growth market.

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🔟 1. Advanced BioMatrix

Headquarters: Carlsbad, California, USA
Key Offering: Medical-Grade Silk Fibroin Powder, Hydrogels, 3D Bio-inks

Advanced BioMatrix is a leading supplier of high-purity, research-grade biomaterials. The company provides ultra-pure silk fibroin powder specifically designed for demanding applications in tissue engineering, drug delivery systems, and 3D cell culture. Their products are characterized by stringent quality control and lot-to-lot consistency, making them a trusted partner for academic and pharmaceutical research.

Innovation Initiatives:

• Development of functionalized silk fibroin for specific biomedical applications

• Focus on biocompatibility testing and regulatory support for clinical translation

• Custom powder formulation services for specialized research needs

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9️⃣ 2. Biosynth

Headquarters: Staad, Switzerland
Key Offering: High-Purity Silk Fibroin Powder, Biochemicals, APIs

Biosynth is a global life sciences supplier with a comprehensive portfolio of biochemicals. Their silk fibroin powder offerings cater to both research and development scale requirements, serving customers in pharmaceuticals, cosmetics, and material science. The company’s strength lies in its robust supply chain and ability to provide materials that meet international quality standards.

Innovation Initiatives:

• Investment in scalable purification technologies for silk fibroin

• Expansion of product lines to include silk-based peptides and composites

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8️⃣ 3. Cocoon Biotech

Headquarters: Boston, Massachusetts, USA
Key Offering: Sterile Silk Fibroin Powder, Drug Delivery Platforms

Cocoon Biotech specializes in developing silk-based biomaterials for therapeutic applications. The company leverages proprietary processing techniques to produce silk fibroin powder with preserved bioactivity and controlled degradation profiles. Their focus is primarily on creating innovative solutions for osteoarthritis treatment and controlled release formulations.

Innovation Initiatives:

• Proprietary silk processing for enhanced drug loading efficiency

• Clinical-stage development of silk-based therapeutics

• Partnerships with pharmaceutical companies for product co-development

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7️⃣ 4. Seidecosa

Headquarters: Le Bourget-du-Lac, France
Key Offering: Cosmetic-Grade Silk Powder, Silk Proteins, Sericin

Seidecosa is a European specialist in the valorization of silk by-products. The company produces a range of silk-derived ingredients, including fine silk fibroin powder optimized for cosmetic formulations. Their expertise in green chemistry extraction methods ensures high-quality, natural ingredients for skincare and haircare products, emphasizing sustainability and efficacy.

Innovation Initiatives:

• Development of eco-friendly extraction processes

• Focus on cosmetic applications with proven efficacy data

• Expansion into nutraceutical and well-being sectors

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Silk Fibroin Powder Market – View in Detailed Research Report

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6️⃣ 5. Huzhou Aotesi Biochemical Co., Ltd.

Headquarters: Huzhou, Zhejiang, China
Key Offering: Industrial & Cosmetic Grade Silk Fibroin Powder

Huzhou Aotesi Biochemical is a major Chinese manufacturer of silk-derived products. Leveraging its location in a key silk-producing region, the company has developed efficient large-scale production capabilities for silk fibroin powder. It serves a broad customer base in the cosmetics, textile auxiliary, and biomedical industries with cost-competitive and consistent quality products.

Innovation Initiatives:

• Scaling up production capacity to meet growing global demand

• Investment in R&D for higher purity grades targeting pharmaceutical applications

• Development of customized particle size distributions for specific client needs

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5️⃣ 6. Kelisema Srl

Headquarters: Bologna, Italy
Key Offering: Silk Fibroin Micro-powders, Natural Biomaterials

Kelisema is an Italian biotechnology company focused on the research, development, and production of innovative materials derived from silk. They produce silk fibroin powders with specific morphological characteristics for advanced applications in regenerative medicine and cosmeceuticals, emphasizing the natural origin and superior performance of their products.

Innovation Initiatives:

• Tailoring powder properties (size, porosity) for specific biological interactions

• Exploring silk fibroin composites with other natural polymers

• Collaborations with European research institutes

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4️⃣ 7. Huzhou Xintiansi Bio-tech Co., Ltd.

Headquarters: Huzhou, Zhejiang, China
Key Offering: Food-Grade & Cosmetic-Grade Silk Fibroin Powder

Huzhou Xintiansi Bio-tech is another significant player from China’s silk region, specializing in the deep processing of silk. The company has established itself as a reliable supplier of silk fibroin powder for the food and beverage industry, where it is used as a natural protein additive, as well as for high-quality cosmetic applications.

Innovation Initiatives:

• Certification of food-grade and organic standards for global market access

• Process optimization for improved yield and reduced environmental impact

• Development of soluble silk protein powders for enhanced application versatility

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3️⃣ 8. Chongqing Haifan Biochemical Co., Ltd.

Headquarters: Chongqing, China
Key Offering: Pharmaceutical & Cosmetic Grade Silk Fibroin

Chongqing Haifan Biochemical is a specialized manufacturer of biological products, including silk fibroin powder. The company focuses on producing high-purity grades suitable for sensitive applications. Its strategic focus on quality control and adherence to Good Manufacturing Practices (GMP) makes it a growing contender in the market for reliable biopolymer supplies.

Innovation Initiatives:

• Implementation of stringent quality management systems

• R&D focused on Improving the bioavailability of silk fibroin

• Expansion of product portfolio to include silk-based hydrogels and films

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2️⃣ 9. Zhejiang Xingyue Biotechnology Co., Ltd.

Headquarters: Jiaxing, Zhejiang, China
Key Offering: Nano-Silk Fibroin Powder, Cosmetic Ingredients

Zhejiang Xingyue Biotechnology specializes in the nano-technology processing of natural biomaterials. The company produces nano-grade silk fibroin powder, which offers superior properties for cosmetic formulations, including enhanced skin penetration and transparency. Their technological edge lies in achieving controlled particle sizes at the nanoscale while maintaining protein integrity.

Innovation Initiatives:

• Pioneering nano-milling and dispersion technologies for silk protein

• Developing synergistic blends of silk fibroin with other active cosmetic ingredients

• Targeting high-value applications in anti-aging and premium skincare

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1️⃣ 10. Xi’an Sost Biotech Co., Ltd.

Headquarters: Xi’an, Shaanxi, China
Key Offering: Standard and Customized Silk Fibroin Powders

Xi’an Sost Biotech is a supplier of natural plant and animal extracts, including silk fibroin powder. The company serves a global clientele by providing a range of purity grades tailored to customer specifications. Their business model emphasizes flexibility and the ability to supply both small-scale research quantities and larger commercial batches.

Innovation Initiatives:

• Providing extensive technical data and certificates of analysis for all products

• Offering custom extraction and purification services

• Expanding its online presence and direct-to-researcher sales channels

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Silk Fibroin Powder Market – View in Detailed Research Report

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🌍 Outlook: The Future of Silk Fibroin Powder Is Multifunctional and High-Value

The silk fibroin powder market is experiencing a paradigm shift from a niche biomaterial to a versatile platform ingredient. While traditional applications in cosmetics and textiles continue to grow, the most significant value creation is occurring in advanced biomedical applications and sustainable materials. The industry is investing heavily in R&D to enhance functionality, improve production economics, and unlock new application paradigms.

📈 Key Trends Shaping the Market:

• R&D expansion in tissue engineering and regenerative medicine, utilizing silk’s excellent scaffold properties.

• Growing adoption in cosmeceuticals for its moisturizing, anti-aging, and film-forming benefits.

• Exploration of silk fibroin in edible coatings and sustainable packaging to reduce plastic waste.

• Technological advancements in extraction and purification leading to higher yields and lower costs.

Get Full Report Here:
Silk Fibroin Powder Market – View in Detailed Research Report

The companies profiled above are not merely suppliers of a raw material—they are enablers of innovation across multiple high-growth industries, transforming a natural wonder into the building blocks of a more sustainable and healthier future.