The Global Casein Hydrolase Market was valued at USD 243.7 Million in 2023 and is projected to reach USD 382.1 Million by 2030, growing at a Compound Annual Growth Rate (CAGR) of 6.8% during the forecast period (2024–2030). This robust growth is being driven by the rising demand for protein-fortified foods, the expansion of the functional food and beverage sector, and the increasing application of casein hydrolysates in pharmaceutical and cosmetic formulations.

As industries increasingly focus on bioactive ingredients and enhanced protein digestibility, the spotlight is on the key enzyme manufacturers and biotech firms driving innovation in protein hydrolysis. In this blog, we profile the Top 10 Companies in the Casein Hydrolase Industry—a mix of established enzyme giants and specialized biotech pioneers shaping the future of protein ingredient solutions.

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🔟 1. Novozymes A/S

Headquarters: Bagsværd, Denmark
Key Offering: Protease enzymes for casein hydrolysis, Custom enzyme solutions

Novozymes is a global leader in biological solutions, offering a comprehensive portfolio of enzymes for industrial applications. Their protease enzymes are extensively used for controlled hydrolysis of casein to produce bioactive peptides, hypoallergenic infant formula ingredients, and protein supplements with enhanced functional properties.

Innovation Initiatives:

• Advanced fermentation technology for high-yield enzyme production

• R&D in tailored enzymatic processes for specific peptide profiles

• Sustainable production methods aligning with circular economy principles

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Casein Hydrolase Market – View in Detailed Research Report

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9️⃣ 2. DSM-Firmenich

Headquarters: Kaiseraugst, Switzerland
Key Offering: MaxiPro® CASEIN, Specialty enzyme blends for dairy protein hydrolysis

Following the merger of DSM and Firmenich, the company has strengthened its position in specialty ingredients, including enzymes for protein modification. Their expertise lies in producing consistent and high-quality casein hydrolysates for nutritional and pharmaceutical applications, with a focus on improving bioavailability and reducing allergenicity.

Innovation Initiatives:

• Development of precision fermentation-derived enzymes

• Expansion of product portfolio for sports nutrition and clinical diets

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8️⃣ 3. Advanced Enzyme Technologies Ltd.

Headquarters: Thane, Maharashtra, India
Key Offering: AET Enzyme Kits for Casein Hydrolysis, Customized enzyme formulations

Advanced Enzyme Technologies is one of India’s leading enzyme companies with a significant global footprint. They specialize in developing thermally stable and highly specific proteases for hydrolyzing casein, catering to the food, feed, and pharmaceutical industries with a strong emphasis on research-driven solutions.

Innovation Initiatives:

• Investment in R&D for novel enzyme discovery from diverse microbial sources

• Focus on clean-label and non-GMO enzyme solutions for the global market

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7️⃣ 4. Chr. Hansen Holding A/S

Headquarters: Hørsholm, Denmark
Key Offering: Microbial proteases, Enzyme systems for dairy protein processing

Chr. Hansen is a global bioscience company renowned for its microbial and enzyme technology. Their enzyme division provides robust protease solutions used in the dairy industry to hydrolyze casein, improving functionality in products like protein bars, beverages, and infant nutrition.

Innovation Initiatives:

• Sustainable enzyme production using state-of-the-art biotechnology

• Collaborations with food manufacturers to develop next-generation protein ingredients

Download FREE Sample Report:
Casein Hydrolase Market – View in Detailed Research Report

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6️⃣ 5. BASF SE

Headquarters: Ludwigshafen, Germany
Key Offering: Enzymes for nutrition and health, Custom hydrolysis solutions

BASF’s nutrition and health division offers a range of enzyme products, including those suitable for protein hydrolysis. While its primary strength lies in vitamins and carotenoids, BASF provides integrated solutions that include enzymatic processing aids for creating specialized protein ingredients like casein hydrolysates.

Innovation Initiatives:

• Integration of enzyme technology into broader nutrition solution platforms

• Research into enzyme applications for personalized nutrition

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5️⃣ 6. Creative Enzymes

Headquarters: Shirley, New York, USA
Key Offering: High-purity casein hydrolase, Research-grade and industrial-scale enzymes

Creative Enzymes is a specialized supplier focusing exclusively on enzyme products and services. They provide high-purity casein hydrolase enzymes crucial for research institutions, diagnostic kit manufacturers, and food R&D labs, offering both off-the-shelf products and custom enzyme development services.

Innovation Initiatives:

• Extensive catalog of rare and specialty enzymes

• Custom enzyme screening and optimization services for specific client needs

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4️⃣ 7. Specialty Enzymes & Probiotics

Headquarters: Chino, California, USA
Key Offering: SEPROZYME® Proteases, Enzyme blends for dairy and nutrition

Specialty Enzymes & Probiotics is a recognized manufacturer of enzymes for food, dietary supplements, and animal nutrition. Their protease enzymes are effectively used for casein hydrolysis, providing solutions that enhance protein digestibility and create functional ingredients for health-focused products.

Innovation Initiatives:

• Development of enzyme combinations for synergistic hydrolysis effects

• Focus on GRAS (Generally Recognized as Safe) and halal/kosher certified enzymes

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3️⃣ 8. Amano Enzyme Inc.

Headquarters: Nagoya, Japan
Key Offering: Amano Proteases, Enzymes for food processing and analysis

Amano Enzyme is a Japanese pioneer in enzyme technology with a strong presence in the global market. The company offers a variety of proteases derived from microbial and fungal sources, which are used to hydrolyze casein for applications ranging from flavor enhancement in foods to the production of bioactive peptides.

Innovation Initiatives:

• Long-standing expertise in microbial enzyme fermentation

• Continuous improvement of enzyme specificity and activity for cleaner hydrolysis

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2️⃣ 9. Enzyme Development Corporation

Headquarters: New York, New York, USA
Key Offering: Custom enzyme formulations, Technical support for protein hydrolysis

Enzyme Development Corporation specializes in providing tailored enzyme solutions for various industrial processes. They work closely with clients in the food and ingredient sectors to develop optimal enzymatic approaches for casein hydrolysis, focusing on achieving desired degrees of hydrolysis and functional outcomes.

Innovation Initiatives:

• Customer-centric approach with extensive technical application support

• Selection of enzymes from multiple global producers to provide optimal solutions

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1️⃣ 10. Biocatalysts Ltd.

Headquarters: Cardiff, United Kingdom
Key Offering: Neutrase® and other proteases, Enzyme solutions for protein modification

Biocatalysts Ltd. is a specialist enzyme company known for its innovative approach to developing enzymes for the food and beverage industry. Their protease products, including those suitable for casein hydrolysis, are used to create hydrolyzed proteins with improved solubility, emulsification, and nutritional profiles.

Innovation Initiatives:

• Proprietary enzyme screening and development platform (Eazyzyme®)

• Rapid prototyping and scale-up capabilities for custom enzyme projects

Get Full Report Here:
Casein Hydrolase Market – View in Detailed Research Report

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🔬 Outlook: The Future of Casein Hydrolase Is Precision and Personalization

The casein hydrolase market is undergoing a significant transformation, evolving from bulk enzyme supply to precision biotech solutions. As consumer demand for personalized nutrition and functional foods rises, the industry is investing in advanced bioprocessing technologies and novel enzyme discovery.

📈 Key Trends Shaping the Market:

• R&D into microbial proteases with specific cleavage sites for targeted bioactive peptide release

• Growing adoption in sports nutrition and clinical nutrition for muscle recovery and specialized diets

• Increasing regulatory emphasis on enzyme safety and clean-label product formulations

• Expansion of application scope into cosmetics for anti-aging and skin health products

Get Full Report Here:
Casein Hydrolase Market – View in Detailed Research Report

The companies listed above are not only supplying essential enzymes—they’re pioneering the next generation of protein ingredient technology for a health-conscious world.