The Global Menaquinones Market was valued at USD 355.2 Million in 2024 and is projected to reach USD 552.8 Million by 2030, growing at a Compound Annual Growth Rate (CAGR) of 7.6% during the forecast period (2024–2030). This growth is primarily driven by increasing consumer awareness of Vitamin K2’s critical role in bone and cardiovascular health, the rising prevalence of osteoporosis, and the expanding application of menaquinones in fortified foods and dietary supplements.

As the nutraceutical and pharmaceutical industries increasingly recognize the importance of Vitamin K2 (menaquinone) for its superior bioavailability and health benefits compared to Vitamin K1, the market is witnessing significant innovation and strategic expansion. In this blog, we profile the Top 10 Companies in the Menaquinones Industry—a mix of specialized ingredient suppliers, pharmaceutical giants, and biotechnology firms shaping the future of this essential nutrient.

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🔟 1. Kappa Bioscience AS

Headquarters: Oslo, Norway
Key Offering: K2Vital® Methylmenaquinone-7 (MK-7)

A subsidiary of Gnosis by Lesaffre, Kappa Bioscience is a global leader in the production of high-purity, synthetic Vitamin K2 as MK-7. The company’s proprietary K2Vital® technology ensures superior stability and bioavailability, making it a preferred ingredient for dietary supplements and functional foods worldwide.

Innovation & Market Strategy:

• Pioneer in all-trans MK-7 production
• Strong focus on clinical research to substantiate health claims
• Strategic global distribution network

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9️⃣ 2. NattoPharma ASA

Headquarters: Oslo, Norway
Key Offering: MenaQ7® (Natural MK-7 from natto)

NattoPharma, now part of Gnosis by Lesaffre, was a foundational company in establishing the clinical evidence base for Vitamin K2. Its flagship product, MenaQ7®, is a patented, naturally fermented MK-7 derived from the Japanese food natto, backed by numerous human clinical trials.

Innovation & Market Strategy:

• Extensive portfolio of clinical research on bone and heart health
• Strong intellectual property portfolio for natural MK-7
• Focus on pharmaceutical and high-potency supplement applications

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8️⃣ 3. Gnosis by Lesaffre

Headquarters: Marcq-en-Barœul, France
Key Offering: MenaQ7® & K2Vital® (both synthetic and natural MK-7)

Following its acquisitions of NattoPharma and Kappa Bioscience, Gnosis by Lesaffre has become the undisputed global leader in the Menaquinones market. The company leverages fermentation expertise to offer a comprehensive portfolio of bioactive ingredients, including a full spectrum of Vitamin K2 solutions.

Innovation & Market Strategy:

• Combined strengths of natural and synthetic MK-7 production
• Vertically integrated manufacturing from fermentation to finished product
• Investment in next-generation menaquinone forms like MK-4 and longer-chain variants

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Menaquinones Market – View in Detailed Research Report

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7️⃣ 4. Royal DSM N.V.

Headquarters: Heerlen, Netherlands
Key Offering: MenaquinGold™ (Micro-encapsulated MK-7)

DSM, a global science-based company active in health, nutrition, and bioscience, offers innovative Vitamin K2 solutions. Its MenaquinGold™ product features micro-encapsulated MK-7 for enhanced stability in a wide range of applications, from tablets to functional foods.

Innovation & Market Strategy:

• Strong R&D capabilities in microbial fermentation
• Global reach and extensive customer base in human and animal nutrition
• Focus on synergistic formulations with Vitamin D3 and other micronutrients

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6️⃣ 5. Viridis BioPharma Pvt. Ltd.

Headquarters: Mumbai, India
Key Offering: Pharmaceutical-grade Menaquinone (MK-4, MK-7)

Viridis BioPharma is a leading Indian manufacturer of active pharmaceutical ingredients (APIs) and nutraceuticals, specializing in fermentation-derived products. The company has built a strong reputation for quality and cost-effectiveness in the menaquinone market.

Innovation & Market Strategy:

• Strategic focus on cost-competitive production for emerging markets
• Expanding capacity for both MK-4 and MK-7 isoforms
• Strong presence in the Asian and Middle Eastern pharmaceutical sectors

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5️⃣ 6. International Flavors & Fragrances Inc. (IFF)

Headquarters: New York, USA
Key Offering: Vitamin K2 as part of broad health & wellness portfolio

Following its merger with DuPont’s Nutrition & Biosciences unit, IFF possesses a formidable portfolio of health ingredients. While not a primary menaquinone specialist, the company offers Vitamin K2 solutions through its extensive capabilities in microbial fermentation and ingredient science.

Innovation & Market Strategy:

• Leverages scale and customer relationships from the merged entity
• Focus on integrated ingredient solutions for food, beverage, and supplement manufacturers
• Investment in sustainable production technologies

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4️⃣ 7. Dyadic International, Inc.

Headquarters: Jupiter, Florida, USA
Key Offering: C1 platform for efficient menaquinone production

Dyadic is a biotechnology company focused on developing and deploying its proprietary C1 microbial protein production platform. This technology is being applied to produce a variety of proteins, enzymes, and metabolites, including Vitamin K2, at lower costs and higher yields.

Innovation & Market Strategy:

• Proprietary C1 hyper-expression technology platform
• Strategic partnerships for commercial-scale production
• Focus on disrupting production economics for high-value metabolites

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Menaquinones Market – View in Detailed Research Report

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3️⃣ 8. GeneFerm Biotechnology Co., Ltd.

Headquarters: Taoyuan City, Taiwan
Key Offering: Fermentation-derived Menaquinone (MK-4, MK-7)

GeneFerm is a leading Asian biotechnology company specializing in microbial fermentation for the production of vitamins, amino acids, and other fine chemicals. The company has established itself as a reliable supplier of menaquinones for the regional and global markets.

Innovation & Market Strategy:

• Strong R&D focus on strain improvement and fermentation optimization
• Strategic location catering to the high-growth Asia-Pacific market
• Competitive pricing strategy for bulk ingredient supply

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2️⃣ 9. Kyowa Hakko Bio Co., Ltd.

Headquarters: Tokyo, Japan
Key Offering: Menaquinone-4 (MK-4) ingredients

As part of the Kirin Holdings Group, Kyowa Hakko Bio is a globally recognized leader in fermentation technology. The company produces a range of bio-chemicals and has expertise in manufacturing Vitamin K2, particularly the MK-4 form used in pharmaceutical applications in Japan.

Innovation & Market Strategy:

• Decades of experience in industrial fermentation
• Strong presence in the pharmaceutical sector, especially in Japan
• Focus on “Bio-based” and “Human Healthcare” corporate philosophy

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1️⃣ 10. Seebio Biotech (Shanghai) Co., Ltd.

Headquarters: Shanghai, China
Key Offering: Menaquinone (MK-4, MK-7) for supplements and food fortification

Seebio Biotech is a prominent Chinese manufacturer of fine chemicals and nutraceutical ingredients. The company has invested in fermentation capabilities for menaquinone production, catering to the rapidly growing domestic and international demand for Vitamin K2.

Innovation & Market Strategy:

• Cost-advantaged manufacturing base in China
• Rapid scaling capabilities to meet increasing global demand
• Focus on both standard and customized menaquinone formulations

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🌍 Outlook: The Future of Menaquinones Is Precision Health and Broader Applications

The menaquinones market is experiencing a transformative phase, moving from a niche nutraceutical ingredient to a mainstream component of preventative health strategies. The convergence of stronger clinical evidence, aging global populations, and innovative delivery formats is fueling robust growth.

📈 Key Trends Shaping the Market:

• Expansion of clinical applications beyond bone health to cardiovascular, cognitive, and metabolic wellness
• Increasing fortification of staple foods and beverages with Vitamin K2
• Rising demand for plant-based and vegan-friendly MK-7 sourced from non-animal fermentation
• Strategic consolidations and partnerships to secure supply chains and expand geographic reach

Get Full Report Here:
Menaquinones Market – View in Detailed Research Report

The companies listed above are not only supplying a critical nutrient—they’re pioneering the integration of targeted nutrition into global health and wellness paradigms.