The Global N-Acetyl-L-Hydroxyproline Market was valued at USD 62.3 Million in 2023 and is projected to reach USD 89.7 Million by 2028, growing at a Compound Annual Growth Rate (CAGR) of 7.1% during the forecast period (2023–2028). This robust growth is primarily fueled by the expanding global cosmetics industry, increased consumer demand for advanced anti-aging skincare products, and the compound’s proven efficacy in enhancing skin hydration and collagen synthesis.

As the beauty and personal care sector increasingly prioritizes scientifically-backed, bioactive ingredients, the spotlight turns to the key manufacturers who are ensuring a stable and high-quality supply of N-Acetyl-L-Hydroxyproline. In this blog, we profile the Top 10 Companies in the Global N-Acetyl-L-Hydroxyproline Industry—a blend of established amino acid specialists, chemical innovators, and ingredient suppliers shaping the future of cosmetic formulations.

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🔟 1. KYOWA HAKKO BIO CO., LTD.

Headquarters: Tokyo, Japan
Key Offering: High-Purity N-Acetyl-L-Hydroxyproline, Pharmaceutical and Cosmetic-Grade Amino Acids

Kyowa Hakko Bio is a globally recognized leader in the fermentation technology and production of amino acids. The company is a primary supplier of high-purity N-Acetyl-L-Hydroxyproline, leveraging its proprietary bio-fermentation processes to ensure superior quality and consistency for the cosmetic and pharmaceutical industries.

Innovation Initiatives:

• Pioneering research in amino acid applications for skin health

• Development of sustainable fermentation-based production methods

• Strategic partnerships with major global cosmetic brands

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Global N-Acetyl-L-Hydroxyproline Market – View in Detailed Research Report

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9️⃣ 2. Shijiazhuang Haitian Amino Acid Co., Ltd.

Headquarters: Shijiazhuang, Hebei, China
Key Offering: N-Acetyl-L-Hydroxyproline (Purity ≥99%), Custom Amino Acid Derivatives

Shijiazhuang Haitian is a major Chinese manufacturer specializing in amino acids and their derivatives. The company has established a strong position in the N-Acetyl-L-Hydroxyproline market by offering competitive pricing and reliable supply chains, catering predominantly to the burgeoning Asia-Pacific cosmetics market.

Innovation Initiatives:

• Expansion of production capacity to meet growing global demand

• Focus on cost-effective chemical synthesis routes

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8️⃣ 3. Evonik Industries AG

Headquarters: Essen, Germany
Key Offering: Specialty Ingredients, N-Acetyl-L-Hydroxyproline for Premium Cosmetics

Evonik’s Health & Care division is a key player in the specialty chemicals space, supplying high-performance ingredients to the personal care industry. Their offering of N-Acetyl-L-Hydroxyproline is backed by extensive R&D into its mechanism of action for improving skin barrier function and reducing the appearance of wrinkles.

Innovation Initiatives:

• Investment in green chemistry and sustainable ingredient sourcing

• Development of synergistic ingredient systems with N-Acetyl-L-Hydroxyproline

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7️⃣ 4. Ajinomoto Co., Inc.

Headquarters: Tokyo, Japan
Key Offering: AminoScience® Products, Including N-Acetyl-L-Hydroxyproline

Ajinomoto, a world leader in amino acid science, produces N-Acetyl-L-Hydroxyproline under its esteemed AminoScience brand. The company’s expertise in amino acid technology ensures a product of exceptional purity, making it a preferred choice for high-end cosmetic formulations worldwide.

Innovation Initiatives:

• Clinical studies validating the efficacy of amino acids in cosmetics

• Global distribution network supporting seamless ingredient supply

Download FREE Sample Report:
Global N-Acetyl-L-Hydroxyproline Market – View in Detailed Research Report

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6️⃣ 5. Bachem AG

Headquarters: Bubendorf, Switzerland
Key Offering: High-Purity Peptide Building Blocks, N-Acetyl-L-Hydroxyproline

Bachem is a premier supplier of peptides and organic fine chemicals, including N-Acetyl-L-Hydroxyproline, which is widely used as a building block in peptide synthesis for pharmaceutical and cosmetic applications. Their commitment to cGMP standards guarantees a product of the highest quality.

Innovation Initiatives:

• Focus on pharmaceutical-grade purity for sensitive applications

• Advanced analytical methods for quality control

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5️⃣ 6. Sigma-Aldrich (Merck KGaA)

Headquarters: Darmstadt, Germany
Key Offering: N-Acetyl-L-Hydroxyproline for Research and Development

As part of Merck KGaA, Sigma-Aldrich is a leading life science supplier that provides N-Acetyl-L-Hydroxyproline primarily to research institutions, universities, and R&D departments of cosmetic companies. Their product is essential for exploratory studies and new formulation development.

Innovation Initiatives:

• Supporting academic and industrial research with high-purity chemicals

• Providing comprehensive technical data and support

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4️⃣ 7. Wacker Chemie AG

Headquarters: Munich, Germany
Key Offering: Biosolutions Products, Cyclodextrin Complexes with Active Ingredients

Wacker Chemie specializes in silicone and biosolutions, with capabilities in developing sophisticated delivery systems for cosmetic actives. While not a primary producer, they utilize ingredients like N-Acetyl-L-Hydroxyproline in their proprietary formulations to enhance stability and bioavailability in final products.

Innovation Initiatives:

• Development of novel encapsulation technologies for active ingredients

• Focus on enhancing the performance of cosmetic raw materials

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3️⃣ 8. Spec-Chem Industry Inc.

Headquarters: Taipei, Taiwan
Key Offering: Cosmetic Active Ingredients, Including Skin Moisturizing Agents

Spec-Chem is a prominent supplier of cosmetic ingredients in Asia, offering a diverse portfolio that includes raw materials for moisturizing and anti-aging products. They source and supply N-Acetyl-L-Hydroxyproline to formulators across the region, emphasizing its role in advanced skincare solutions.

Innovation Initiatives:

• Building strong supply chain partnerships with Chinese manufacturers

• Providing technical formulation support to cosmetic brands

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2️⃣ 9. Hangzhou Hyper Chemicals Limited

Headquarters: Hangzhou, Zhejiang, China
Key Offering: Amino Acid Derivatives, N-Acetyl-L-Hydroxyproline

Hangzhou Hyper Chemicals is a specialized manufacturer of fine chemicals and pharmaceutical intermediates, including N-Acetyl-L-Hydroxyproline. The company serves both domestic and international markets, competing on quality and scalability.

Innovation Initiatives:

• Optimization of synthetic pathways for improved yield and purity

• Expansion of export operations to Europe and North America

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1️⃣ 10. NutraGreen Bio-Technology Co., Ltd.

Headquarters: Xi’an, Shaanxi, China
Key Offering: Plant Extracts and Amino Acids for Cosmetics and Nutraceuticals

NutraGreen combines expertise in botanical extracts with the production of amino acids like N-Acetyl-L-Hydroxyproline. The company markets these ingredients for their dual benefits in cosmetic and nutraceutical applications, tapping into the trend of inner and outer beauty.

Innovation Initiatives:

• Research into the synergistic effects of botanicals and amino acids

• Promotion of naturally-derived and bioactive ingredients

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Global N-Acetyl-L-Hydroxyproline Market – View in Detailed Research Report

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🌍 Outlook: The Future of N-Acetyl-L-Hydroxyproline Is Multifunctional and Integrated

The N-Acetyl-L-Hydroxyproline market is experiencing a significant transformation. While its primary application remains in anti-aging cosmetics, the industry is exploring new frontiers in pharmaceutical applications and nutricosmetics.

📈 Key Trends Shaping the Market:

• Rising demand for scientifically-proven, bioactive ingredients in skincare

• Expansion into regenerative medicine and wound healing applications

• Growing consumer awareness of ingredients leading to “cosmeceutical” growth

• Increased investment in green and sustainable production technologies

Get Full Report Here:
Global N-Acetyl-L-Hydroxyproline Market – View in Detailed Research Report

The companies listed above are not only supplying a critical cosmetic ingredient—they’re enabling the next generation of advanced skincare and wellness products.