The Global Protein Chromatography Resin Market was valued at USD 3.2 Billion in 2024 and is projected to reach USD 5.8 Billion by 2030, growing at a Compound Annual Growth Rate (CAGR) of 9.5% during the forecast period (2024–2030). This significant growth is fueled by the expanding biopharmaceutical industry, increasing demand for monoclonal antibodies (mAbs), and the critical role of chromatography in downstream purification processes for vaccines and therapeutic proteins.

As biomanufacturing scales up to meet global healthcare demands, the quality and efficiency of purification are paramount. The key resin suppliers are at the forefront of developing high-capacity, robust, and innovative solutions. In this blog, we profile the Top 10 Companies in the Protein Chromatography Resin Industry—a group of life science giants and specialized technology firms shaping the future of biologics production.

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🔟 1. Cytiva (Danaher)

Headquarters: Marlborough, Massachusetts, USA
Key Offering: ÄKTA™ chromatography systems, MabSelect™, Capto™ resin series

Cytiva, part of the Danaher corporation, is a global leader in bioprocessing technologies. Its portfolio of protein A, ion exchange, and multimodal chromatography resins is industry-standard for the purification of monoclonal antibodies and other recombinant proteins.

Innovation & Capacity Initiatives:

• Continuous investment in high-capacity MabSelect PrismA™ resin

• Expansion of resin manufacturing facilities in the US and Sweden

• Development of ready-to-process columns for faster biomanufacturing workflows

Download FREE Sample Report:
Global Protein Chromatography Resin Market – View in Detailed Research Report

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9️⃣ 2. Merck KGaA

Headquarters: Darmstadt, Germany
Key Offering: Eshmuno®, ProSep®, Capto® (licensed) resins

Merck’s Life Science business, operating as MilliporeSigma in the U.S., offers a comprehensive range of chromatography resins and filter membranes. The company’s Eshmuno brand includes high-performance protein A resins that are widely adopted for large-scale antibody purification.

Innovation & Capacity Initiatives:

• Strategic focus on increasing global production capacity for biologics

• R&D into novel ligands for challenging protein purification

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8️⃣ 3. Purolite Corporation

Headquarters: King of Prussia, Pennsylvania, USA
Key Offering: Praesto® agarose-based resins, protein A ligands

Purolite, a prominent player in separation and purification technologies, provides high-flow agarose beads and robust protein A ligands through its Praesto platform. The company is known for its focus on cost-effective and high-performing solutions for the biopharma sector.

Innovation & Capacity Initiatives:

• Expansion of its global manufacturing footprint

• Development of next-generation agarose beads with enhanced binding capacity

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7️⃣ 4. Thermo Fisher Scientific

Headquarters: Waltham, Massachusetts, USA
Key Offering: POROS™ resins, Gibco™ chromatography products

Thermo Fisher Scientific offers the POROS series of high-performance chromatography resins, which are known for their high binding capacity and chemical stability. These products are integral to the downstream processing workflows of many biopharmaceutical companies.

Innovation & Capacity Initiatives:

• Integration of chromatography resins with its broader bioproduction ecosystem

• Focus on developing resins for mRNA and viral vector purification

Download FREE Sample Report:
Global Protein Chromatography Resin Market – View in Detailed Research Report

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6️⃣ 5. Repligen Corporation

Headquarters: Waltham, Massachusetts, USA
Key Offering: OPUS® pre-packed columns, Protein A ligands (via acquisitions)

Repligen has transformed into a leading provider of bioprocessing technologies, largely through strategic acquisitions. The company offers protein A ligands and a full suite of chromatography columns and systems, focusing on enabling continuous and integrated biomanufacturing.

Innovation & Capacity Initiatives:

• Aggressive acquisition strategy to build a full chromatography workflow

• Pioneering development of continuous chromatography systems

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5️⃣ 6. Bio-Rad Laboratories

Headquarters: Hercules, California, USA
Key Offering: NGC™ Chromatography Systems, UNOsphere™ and CHT™ Ceramic Hydroxyapatite resins

Bio-Rad is a well-established life science research and clinical diagnostics company. Its chromatography division provides robust resins and systems used extensively for protein purification in both research and process development scales.

Innovation & Capacity Initiatives:

• Strong focus on chromatography for research and process development

• Ongoing development of novel resin chemistries for complex separations

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4️⃣ 7. GenScript Biotech Corporation

Headquarters: Piscataway, New Jersey, USA
Key Offering: Gene synthesis, antibodies, and protein services including purification resins

GenScript is a leading life sciences contract research and development organization. It offers a range of protein purification resins and services, leveraging its expertise in antibody development and recombinant protein production.

Innovation & Capacity Initiatives:

• Integration of resin offerings with its end-to-end biologics development services

• Focus on high-affinity protein A and G resins for research-grade purification

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3️⃣ 8. Tosoh Corporation

Headquarters: Tokyo, Japan
Key Offering: TSKgel® chromatography columns and resins

Tosoh Corporation is a major Japanese chemical and specialty materials company. Its Bioscience division produces high-quality TSKgel chromatography columns and resins, which are widely used for analytical and preparative protein separation in the biopharmaceutical industry.

Innovation & Capacity Initiatives:

• Long-standing expertise in polymer-based resin technology

• Strong market presence in Asia-Pacific and growing global footprint

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2️⃣ 9. Agilent Technologies

Headquarters: Santa Clara, California, USA
Key Offering: AdvanceBio resins, HPLC/UHPLC columns for protein analysis

While renowned for its analytical instruments, Agilent also provides chromatography columns and resins designed for protein characterization and purification. Its products are critical for quality control and analytical testing in biopharma.

Innovation & Capacity Initiatives:

• Development of columns for high-resolution separations of complex proteins

• Focus on analytical and quality control applications in biomanufacturing

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1️⃣ 10. Kaneka Corporation

Headquarters: Osaka, Japan
Key Offering: Kaneka Capcell Pharma resins

Kaneka Corporation produces high-performance chromatography media, including its proprietary polymer-based resins. These resins are designed for the separation and purification of pharmaceuticals, including large biomolecules like proteins and antibodies.

Innovation & Capacity Initiatives:

• Specialization in polymer-based chromatography media with high chemical stability

• Investment in scaling up production to meet growing global demand

Get Full Report Here:
Global Protein Chromatography Resin Market – View in Detailed Research Report

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🔬 Outlook: The Future of Protein Chromatography is High-Throughput and Continuous

The protein chromatography resin market is evolving rapidly. While traditional batch purification remains dominant, the industry is shifting towards continuous bioprocessing, which demands resins with higher durability, capacity, and faster kinetics.

📈 Key Trends Shaping the Market:

• Rising adoption of multi-modal and mixed-mode resins for complex separations

• Growing demand for pre-packed, ready-to-use columns to reduce validation time

• Increased focus on resin reusability and lifetime to lower the cost of goods

• Expansion of biosimilar and biobetter development, driving resin demand

Get Full Report Here:
Global Protein Chromatography Resin Market – View in Detailed Research Report

The companies listed above are not only supplying essential purification tools—they are enabling the development and production of next-generation biologics that are transforming modern medicine.