The Global Protein Chromatography Resin Market was valued at USD 3.5 Billion in 2024 and is projected to reach USD 6.2 Billion by 2030, growing at a Compound Annual Growth Rate (CAGR) of 9.8% during the forecast period (2024–2030). This robust growth is primarily driven by the expanding biopharmaceutical sector, increasing demand for monoclonal antibodies and vaccines, and the critical role of chromatography in ensuring the purity and safety of biologic drugs.

As biomanufacturing scales up to meet global healthcare demands, the efficiency of downstream purification processes becomes paramount. Protein chromatography resins are the workhorse of these processes, enabling the high-purity separation of complex biological molecules. In this blog, we profile the Top 10 Companies in the Protein Chromatography Resin Industry—a group of life science giants and specialized innovators shaping the future of bioprocessing.

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🔟 1. Cytiva (Danaher Corporation)

Headquarters: Marlborough, Massachusetts, USA
Key Offering: MabSelect, Capto, Sepharose, and HiTrap resin series

Cytiva, a global life sciences leader under Danaher, is a dominant force in the chromatography resin market. Its extensive portfolio, including the industry-standard MabSelect affinity resins for antibody purification, serves thousands of biopharmaceutical customers worldwide. The company’s products are integral to the production of most commercially available biologics.

Innovation and Capacity Initiatives:

• Continuous investment in high-capacity, high-flow-rate resins to improve process economics

• Multi-million dollar expansions of resin manufacturing facilities in the US and Sweden

• Development of next-generation resins for complex modalities like bispecific antibodies and cell & gene therapies

Download FREE Sample Report: Protein Chromatography Resin Market – View in Detailed Research Report

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9️⃣ 2. Merck KGaA

Headquarters: Darmstadt, Germany
Key Offering: Eshmuno, ProSep, Fractogel, and Sartobind products

Merck’s Life Science business, operating as MilliporeSigma in the U.S., offers a comprehensive suite of chromatography resins for all stages of bioprocessing. The company is a key supplier for both large-scale commercial manufacturing and research-scale applications, with a strong focus on innovation in membrane chromatography and mixed-mode resins.

Innovation and Capacity Initiatives:

• Leading provider of innovative Eshmuno branded chromatography resins

• Significant investments in sustainable manufacturing and single-use technologies

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8️⃣ 3. Thermo Fisher Scientific

Headquarters: Waltham, Massachusetts, USA
Key Offering: POROS, Nuvia, and HyperCel resin series

Thermo Fisher Scientific provides high-performance chromatography resins through its Gibco and Applied Biosystems portfolios. The company’s POROS resins are renowned for their high binding capacity and mechanical stability, making them ideal for high-throughput and industrial-scale purification processes.

Innovation and Capacity Initiatives:

• Focus on high-throughput and automated purification solutions

• Integrated offerings that combine resins, columns, and instrumentation

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7️⃣ 4. Repligen Corporation

Headquarters: Waltham, Massachusetts, USA
Key Offering: OPUS pre-packed columns, Agarose and Glass-based resins

Repligen has transformed from a bioprocessing equipment supplier into a major chromatography product provider, notably through its acquisition of the chromatography business from GE Healthcare (now Cytiva) in 2020. The company specializes in pre-packed columns and a growing portfolio of base resins.

Innovation and Capacity Initiatives:

• Strategic focus on pre-packed columns to accelerate bioprocess development

• Expansion of manufacturing capacity for protein A and other affinity ligands

Download FREE Sample Report: Protein Chromatography Resin Market – View in Detailed Research Report

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6️⃣ 5. Purolite Corporation (an Ecolab Company)

Headquarters: King of Prussia, Pennsylvania, USA
Key Offering: Praesto, LifeSciences, and ProSep resin lines

Purolite, now part of Ecolab, is a leading manufacturer of chromatography and separation resins. The company is particularly strong in the robust Praesto agarose-based jetting technology platform, which offers high binding capacity and excellent flow properties for large-scale industrial applications.

Innovation and Capacity Initiatives:

• Pioneer in jetting technology for superior resin bead homogeneity

• Global manufacturing footprint with facilities in the US, UK, and China

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5️⃣ 6. Bio-Rad Laboratories

Headquarters: Hercules, California, USA
Key Offering: Affi-Gel, Profinity, and ENrich chromatography resins

Bio-Rad Laboratories offers a wide array of chromatography resins primarily focused on the research and process development markets. Its products are used for laboratory-scale protein purification, method development, and small-scale production, serving academic, government, and industrial research labs globally.

Innovation and Capacity Initiatives:

• Strong presence in the research and academia segments

• Development of specialized resins for challenging purification applications

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4️⃣ 7. Agilent Technologies

Headquarters: Santa Clara, California, USA
Key Offering: AdvanceBio, ZORBAX, and Pursuit resins and columns

While primarily known for analytical instrumentation, Agilent Technologies also supplies preparative and process-scale chromatography resins. The company’s expertise in column chemistry translates to high-performance resins used in both analytical separations and small to mid-scale bioprocessing.

Innovation and Capacity Initiatives:

• Leveraging analytical expertise for preparative chromatography applications

• Focus on high-resolution resins for complex separation challenges

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3️⃣ 8. Tosoh Corporation

Headquarters: Tokyo, Japan
Key Offering: TSKgel, Toyopearl, and Ether-5 OEt resin series

Tosoh Corporation is a major Japanese chemical company with a significant presence in the chromatography market. Its Toyopearl and TSKgel resin families are widely used for both analytical and preparative separations, with a strong market position in Asia and growing global presence.

Innovation and Capacity Initiatives:

• Extensive R&D in polymer-based resin technologies

• Strategic focus on the rapidly growing Asian biopharmaceutical market

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2️⃣ 9. Kaneka Corporation

Headquarters: Osaka, Japan
Key Offering: Kaneka Capcell Pak and other affinity resins

Kaneka Corporation, through its life sciences division, develops and manufactures high-performance chromatography resins. The company has been expanding its footprint in the biochromatography space, offering innovative solutions for the purification of antibodies and other therapeutic proteins.

Innovation and Capacity Initiatives:

• Investment in novel ligand technologies for improved selectivity

• Expansion of manufacturing capabilities to serve global markets

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1️⃣ 10. Mitsubishi Chemical Group

Headquarters: Tokyo, Japan
Key Offering: TOYOPEARL, DIAION resins

Mitsubishi Chemical Group offers a broad range of separation and purification products, including the TOYOPEARL chromatography resins. These resins are used across various applications from laboratory research to industrial-scale biomanufacturing, with a particular strength in ion-exchange and hydrophobic interaction chromatography.

Innovation and Capacity Initiatives:

• Development of multimodal and affinity chromatography solutions

• Focus on sustainability and green chemistry in resin manufacturing

Get Full Report Here: Protein Chromatography Resin Market – View in Detailed Research Report

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🔬 Outlook: The Future of Protein Chromatography Resins Is High-Capacity and Continuous

The protein chromatography resin market is undergoing a significant evolution. While traditional resins continue to dominate current manufacturing, the industry is aggressively investing in next-generation materials that offer higher binding capacities, faster processing, and compatibility with continuous bioprocessing platforms.

📈 Key Trends Shaping the Market:

• Accelerated adoption of multi-modal and mixed-mode resins for complex molecule purification

• Growing demand for resins compatible with continuous bioprocessing operations

• Increasing focus on resin reusability and lifetime extension to reduce costs

• Development of novel affinity ligands beyond Protein A for emerging therapeutic modalities

Get Full Report Here: Protein Chromatography Resin Market – View in Detailed Research Report

The companies listed above are not only supplying essential purification tools—they’re enabling the next wave of biotherapeutic innovation that is transforming patient care worldwide.