The Global and United States Oligonucleotide Market was valued at USD 2.69 Billion in 2023 and is projected to reach USD 7.35 Billion by 2029, growing at a Compound Annual Growth Rate (CAGR) of 18.2% during the forecast period (2023–2029). This robust growth stems from surging demand in gene therapy, personalized medicine, and diagnostics, alongside advancements in synthetic biology, RNA-based therapeutics, and the expanding applications in CRISPR technologies across research, pharmaceutical, and biotechnology sectors.

As the biotechnology landscape evolves toward precision medicine and innovative therapeutic solutions, attention turns to the pivotal players fueling oligonucleotide development. These short DNA or RNA sequences are essential for gene editing, drug discovery, and molecular diagnostics. In this blog, we profile the Top 10 Companies in the Global and United States Oligonucleotide Market—a blend of established biotech firms, synthesis specialists, and diagnostic innovators shaping the future of genomic research and healthcare.

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🔟 1. Abbott Molecular

Headquarters: Abbott Park, Illinois, USA
Key Offering: Custom oligonucleotides for diagnostics, RNA probes, DNA arrays

Abbott Molecular stands out as a leader in molecular diagnostics, providing high-quality oligonucleotides for infectious disease testing and genetic analysis. Their products support applications in PCR assays and hybridization techniques, serving clinical labs and research institutions worldwide. With a focus on scalability and purity, Abbott’s oligonucleotide solutions enable accurate detection in complex samples, driving advancements in healthcare diagnostics.

Innovation Initiatives:

• Development of next-generation sequencing (NGS) compatible oligos

• Partnerships with global health organizations for rapid diagnostic tools

• Investment in automated synthesis for high-throughput production

Download FREE Sample Report: Global and United States Oligonucleotide Market – View in Detailed Research Report

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9️⃣ 2. Thermo Fisher Scientific

Headquarters: Waltham, Massachusetts, USA
Key Offering: Synthetic DNA/RNA oligonucleotides, siRNA, antisense oligos

Thermo Fisher Scientific dominates the oligonucleotide market through its comprehensive portfolio, catering to academic research, pharma R&D, and clinical applications. Their Invitrogen and Applied Biosystems brands offer modified oligonucleotides for gene silencing and amplification, with rigorous quality controls ensuring reliability in sensitive experiments like qPCR and gene editing.

Innovation Initiatives:

• Advancements in lipid nanoparticle delivery for RNA therapeutics

• Expansion of CRISPR-Cas9 guide RNA synthesis capabilities

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8️⃣ 3. PerkinElmer

Headquarters: Waltham, Massachusetts, USA
Key Offering: Oligonucleotides for genomics, fluorescence probes, microarray tech

PerkinElmer excels in providing oligonucleotides for high-content screening and imaging applications. Their solutions integrate seamlessly with automated workflows, supporting drug discovery and genetic screening. By leveraging proprietary modifications, PerkinElmer enhances probe stability and specificity, making them indispensable for fluorescence in situ hybridization (FISH) and gene chip technologies.

Innovation Initiatives:

• Targets for 100% sustainable synthesis processes by 2030

• Collaborations with biotech startups for custom oligo design in rare disease research

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7️⃣ 4. Integrated DNA Technologies (IDT)

Headquarters: Coralville, Iowa, USA
Key Offering: Custom DNA/RNA synthesis, qPCR probes, CRISPR components

Integrated DNA Technologies (IDT), a Danaher company, is renowned for rapid turnaround in custom oligonucleotide manufacturing. Serving over 100,000 customers globally, IDT’s offerings include high-fidelity oligos for NGS library prep and therapeutic development. Their emphasis on purity above 98% supports precise applications in electrophoresis and therapeutic vector production.

Innovation Initiatives:

• Achieved over 1 million custom orders annually with AI-optimized design tools

• Goal to scale RNA oligo production for mRNA vaccine platforms

Download FREE Sample Report: Global and United States Oligonucleotide Market – View in Detailed Research Report

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6️⃣ 5. SciGene Corporation

Headquarters: Sunnyvale, California, USA
Key Offering: Oligo arrays, microarray printing, DNA synthesis services

SciGene Corporation specializes in microarray technologies, delivering oligonucleotides optimized for gene expression profiling and SNP detection. Their products are widely used in academic and pharmaceutical settings, where high-density arrays enable comprehensive genomic analysis. SciGene’s innovations in surface chemistry improve hybridization efficiency, reducing background noise in diagnostic assays.

Innovation Initiatives:

• Deployment of robotic systems for automated array fabrication

• Focus on long-oligo synthesis for complex genomic studies

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5️⃣ 6. Roche NimbleGen

Headquarters: Madison, Wisconsin, USA
Key Offering: NimbleGen arrays, custom CGH probes, ChIP-on-chip oligos

Roche NimbleGen, part of Roche Diagnostics, leads in array-based comparative genomic hybridization (CGH) with tailored oligonucleotides. Their platforms facilitate cancer genomics and epigenetic research, offering resolutions down to single nucleotide variants. By combining maskless array synthesis, Roche ensures cost-effective, high-resolution tools for global research communities.

Innovation Initiatives:

• Current production exceeds 500,000 probes per array

• Target: Integration of AI for probe design optimization by 2025

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4️⃣ 7. Eurofins Genomics

Headquarters: Ebersberg, Germany (with major US operations)
Key Offering: Oligo synthesis, NGS services, custom RNA/DNA

Eurofins Genomics provides end-to-end oligonucleotide solutions, from synthesis to sequencing, supporting applications in forensics, agriculture, and pharma. Operating in over 50 countries, their US facilities handle high-volume orders for therapeutic-grade oligos, emphasizing modifications like LNA for enhanced binding affinity in antisense therapies.

Innovation Initiatives:

• Geopolitical adaptations for resilient supply chains in oligo production

• R&D in therapeutic oligos for oncology and infectious diseases

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3️⃣ 8. Merck KGaA (Sigma-Aldrich)

Headquarters: Darmstadt, Germany (US HQ in St. Louis, Missouri)
Key Offering: Research-grade oligos, siRNA libraries, custom modifications

Merck KGaA, through Sigma-Aldrich, supplies a vast array of oligonucleotides for basic and applied research. Their portfolio includes ready-to-use kits for RNAi and PCR, serving universities and biotech firms. With global distribution, Merck supports the US market’s demand for scalable synthesis in drug target validation and functional genomics.

Innovation Initiatives:

• Indigenous development of eco-friendly synthesis chemistries

• Collaborations with US research consortia for large-scale oligo screening

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2️⃣ 9. Agilent Technologies

Headquarters: Santa Clara, California, USA
Key Offering: SurePrint arrays, eArray design, RNA/DNA probes

Agilent Technologies is a powerhouse in oligonucleotide microarrays, offering customizable platforms for gene expression and methylation studies. Their SureSelect technology enables targeted NGS enrichment with high-purity oligos, accelerating clinical research in oncology and neurology. Agilent’s US-centric innovation hub drives efficiency in supply chains for North American clients.

Innovation Initiatives:

• Plans to produce 1 billion probes annually by expanding US facilities

• Ongoing expansions in oligo-based liquid biopsy assays

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1️⃣ 10. CytoTest

Headquarters: Rockville, Maryland, USA
Key Offering: FISH probes, chromosomal oligos, multiplex assays

CytoTest specializes in fluorescence in situ hybridization (FISH) probes using locus-specific oligonucleotides, aiding cytogenetic diagnostics for cancer and genetic disorders. Their multiplex kits allow simultaneous detection of multiple targets, enhancing precision in pathology labs. As a US-based innovator, CytoTest supports the growing demand for personalized diagnostics in the American healthcare system.

Innovation Initiatives:

• Comprehensive FISH solutions for global clinical partnerships

• Strategic alliances with academic centers for novel probe development

Read Full Report: Global and United States Oligonucleotide Market – View in Detailed Research Report

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🌍 Outlook: The Future of the Oligonucleotide Market Is Precision-Driven and Therapeutic-Focused

The oligonucleotide market is experiencing transformative growth, propelled by breakthroughs in gene editing and RNA therapeutics. While DNA and RNA segments dominate current volumes, substantial investments are flowing into advanced synthesis methods, application-specific modifications, and global distribution networks to meet rising demands in diagnostics and personalized treatments.

Furthermore, the market’s segmentation by type (DNA and RNA) and application (such as gene chips, electrophoresis, and fluorescence in situ hybridization) highlights diverse opportunities. Regions like North America, particularly the US, lead due to robust R&D ecosystems, while Asia-Pacific emerges as a manufacturing powerhouse. In the US, the focus remains on players driving innovation in therapeutic oligonucleotides for diseases like cancer and rare genetic conditions.

Because of regulatory advancements, such as FDA approvals for oligonucleotide-based drugs, and increasing collaborations between pharma giants and synth providers, the sector anticipates accelerated adoption. However, challenges like synthesis scalability and cost reduction persist, yet ongoing digital integration in design and quality control promises smarter, more efficient pathways.

📈 Key Trends Shaping the Market:

• Rapid expansion of RNA therapeutics capacity in the US, Europe, and Asia-Pacific

• Regulatory incentives for oligonucleotide use in gene therapy and diagnostics by 2029

• Digitalization of oligo design tools and supply chain analytics

• Strategic alliances between companies and research institutions for application diversification

Read Full Report: Global and United States Oligonucleotide Market – View in Detailed Research Report

The companies profiled here are not only powering genomic discoveries—they are at the forefront of the precision medicine revolution, unlocking new frontiers in human health.

To delve deeper into market dynamics, including detailed segmental analysis by type (DNA, RNA), application (Gene Chip, Electrophoresis, Fluorescence In Situ Hybridization), and regions (North America: U.S., Canada; Europe: Germany, France, U.K., Italy, Russia; Asia-Pacific: China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam; Latin America: Mexico, Brazil, Argentina; Middle East & Africa: Turkey, Saudi Arabia, U.A.E.), stakeholders can leverage comprehensive forecasts for 2018-2029. This data empowers players to strategize effectively in a competitive landscape.

In the United States, the market emphasizes local innovation, with key players like Abbott Molecular and PerkinElmer playing crucial roles in domestic growth. The report’s focus on US-specific size, revenue, and projections by type and application provides invaluable insights for regional dominance.

Overall, as oligonucleotide technologies mature, expect heightened integration with AI for custom designs and broader applications in synthetic biology. This evolution will continue to bridge research gaps, fostering sustainable growth across global and US markets alike.