The Global Pharma Grade Hyaluronic Acid API Market was estimated at USD 179.86 million in 2023 and is projected to reach USD 323.88 million by 2029, exhibiting a Compound Annual Growth Rate (CAGR) of 10.30% during the forecast period (2023–2029). This growth is being driven by rising demand for advanced treatments in orthopedics and ophthalmology, increasing prevalence of osteoarthritis and age-related eye conditions, and the expanding use of microbial fermentation-based hyaluronic acid in pharmaceutical formulations worldwide.

As the pharmaceutical industry advances toward innovative therapies for joint health, ocular care, and anti-aging solutions, the spotlight is on the key API manufacturers who are driving purity, innovation, and scalable production methods. In this blog, we profile the Top 10 Companies in the Global Pharma Grade Hyaluronic Acid API Industry—a mix of biotechnology leaders, fermentation specialists, and pharmaceutical pioneers shaping the future of hyaluronic acid applications in medicine.

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🔟 1. Bloomage Biotechnology Corporation Limited

Headquarters: Jinan, Shandong, China
Key Offering: Microbial Fermentation-Derived Hyaluronic Acid API for Injections and Eye Drops

Bloomage Biotechnology stands as a global leader in hyaluronic acid production, supplying high-purity pharma-grade APIs to pharmaceutical companies worldwide. The company specializes in microbial fermentation processes, which ensure consistent quality and scalability for applications in viscosupplementation for osteoarthritis and ophthalmic solutions. With a strong focus on research, Bloomage has expanded its portfolio to include customized molecular weight variants tailored to specific therapeutic needs.

Key Innovations:

• Advanced bio-fermentation technology for high-yield HA production
• Partnerships with global pharma firms for clinical-grade materials
• Commitment to GMP-certified facilities meeting international standards

Download FREE Sample Report: Global Pharma Grade Hyaluronic Acid API Market – View in Detailed Research Report

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9️⃣ 2. Contipro a.s.

Headquarters: Dolní Dobrouč, Czech Republic
Key Offering: Biofermentation and Extraction-Based Hyaluronic Acid for Pharmaceutical Use

Contipro is renowned for its expertise in hyaluronic acid technology, producing pharma-grade APIs through both microbial and animal-derived methods. The company serves major markets in Europe and beyond, providing materials for intra-articular injections and eye care products. Its innovative cross-linking techniques enhance the durability of HA in therapeutic applications, making it a preferred supplier for advanced drug delivery systems.

Key Innovations:

• Development of stabilized HA derivatives for prolonged efficacy
• Collaborations with research institutions on regenerative medicine

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8️⃣ 3. Seikagaku Corporation

Headquarters: Tokyo, Japan
Key Offering: High-Purity Hyaluronic Acid Sodium Salt for Orthopedic Injections

Seikagaku has a long-standing reputation in the development of hyaluronan-based therapeutics, supplying pharma-grade APIs primarily derived from rooster combs or fermentation. The company’s products are integral to treatments for knee osteoarthritis, with a focus on high molecular weight HA that mimics natural synovial fluid. Operating under strict regulatory compliance, Seikagaku exports to North America and Europe, supporting clinical trials and commercial formulations.

Key Innovations:

• Patented purification processes for ultra-pure HA
• Ongoing R&D in combination therapies with other biologics

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7️⃣ 4. Kewpie Corporation

Headquarters: Tokyo, Japan
Key Offering: Fermentation-Produced Hyaluronic Acid API for Ophthalmic and Injectable Products

Kewpie leverages its biochemical expertise to produce non-animal derived hyaluronic acid APIs, emphasizing safety and purity for pharmaceutical applications. The company supplies materials for eye drops used in dry eye syndrome treatment and viscosupplements for joint care. With production facilities adhering to global GMP standards, Kewpie has strengthened its position in the Asia-Pacific market through reliable supply chains and quality assurance.

Key Innovations:

• Optimization of low molecular weight HA for better bioavailability
• Expansion into sustainable sourcing and eco-friendly manufacturing

Download FREE Sample Report: Global Pharma Grade Hyaluronic Acid API Market – View in Detailed Research Report

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6️⃣ 5. HTL Biotechnology

Headquarters: Javené, France
Key Offering: Cross-Linked and Non-Cross-Linked Hyaluronic Acid for Injections

HTL Biotechnology specializes in the manufacturing of hyaluronic acid-based APIs for aesthetic and therapeutic uses, with a strong emphasis on pharma-grade materials for joint and ocular applications. The company’s proprietary OBTI™ technology allows for precise control over HA properties, ensuring compatibility with existing injection devices. HTL serves a diverse client base across Europe and North America, focusing on innovation in viscoelastic formulations.

Key Innovations:

• Advanced cross-linking methods for enhanced tissue integration
• Investment in automated production for consistent quality

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5️⃣ 6. Fidia Farmaceutici S.p.A.

Headquarters: Abano Terme, Italy
Key Offering: Hyaluronic Acid Derivatives for Orthopedic and Wound Care APIs

Fidia Farmaceutici is a pioneer in hyaluronic acid research, producing pharma-grade APIs through extraction and synthesis methods for use in injections and topical formulations. The company excels in developing esterified HA for improved stability in pharmaceutical products targeting osteoarthritis and post-surgical care. With decades of experience, Fidia maintains leadership in the European market while expanding globally through strategic alliances.

Key Innovations:

• Hyaluronic acid ester technology for novel drug delivery
• Clinical collaborations for expanded therapeutic indications

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4️⃣ 7. AWA Biopharm Inc.

Headquarters: Chicago, Illinois, USA
Key Offering: Microbial and Avian-Derived HA APIs for Eye Drops and Injections

AWA Biopharm provides high-quality hyaluronic acid APIs to the pharmaceutical sector, utilizing both fermentation and animal tissue extraction to meet diverse regulatory requirements. The company’s products support formulations for ocular lubricants and intra-articular therapies, with a focus on North American and Asian markets. AWA’s commitment to traceability and purity has earned it trust among formulators seeking reliable raw materials.

Key Innovations:

• Hybrid production approaches for versatile API grades
• Enhancements in solubility for advanced ophthalmic solutions

Download FREE Sample Report: Global Pharma Grade Hyaluronic Acid API Market – View in Detailed Research Report

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3️⃣ 8. Anika Therapeutics, Inc.

Headquarters: Bedford, Massachusetts, USA
Key Offering: Purified Hyaluronan APIs for Orthopedic Injections

Anika Therapeutics develops and supplies pharma-grade hyaluronic acid APIs, primarily for viscosupplementation in treating joint disorders. Sourcing from consistent bacterial fermentation, the company’s materials are used in FDA-approved products that provide pain relief and joint lubrication. Anika’s focus on clinical efficacy and manufacturing excellence positions it as a key player in the U.S. market, with growing international presence.

Key Innovations:

• High-concentration HA formulations for superior joint cushioning
• Regulatory expertise in navigating global approvals

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2️⃣ 9. LG Chem, Ltd.

Headquarters: Seoul, South Korea
Key Offering: Bioengineered Hyaluronic Acid for Pharmaceutical Formulations

LG Chem contributes to the hyaluronic acid API market through its advanced biotechnology division, producing fermentation-based HA for injections and eye care. The company’s scalable production capabilities support large-volume pharmaceutical needs, particularly in Asia-Pacific. With an emphasis on sustainability, LG Chem integrates green chemistry principles into its HA manufacturing, ensuring high purity and environmental compliance.

Key Innovations:

• Genetic engineering for optimized HA yield and quality
• Supply chain integrations with major drug manufacturers

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1️⃣ 10. Hyaltech, Inc.

Headquarters: Ansan, Gyeonggi-do, South Korea
Key Offering: Cross-Linked Hyaluronic Acid APIs for Therapeutic Injections

Hyaltech leads in the development of hyaluronic acid APIs for both medical and aesthetic pharmaceuticals, specializing in cross-linked variants for durable injection products. The company supplies global markets with materials used in osteoarthritis treatments and ocular therapies, backed by robust R&D in polymer science. Hyaltech’s facilities meet stringent international standards, facilitating exports to Europe, North America, and beyond.

Key Innovations:

• Proprietary cross-linking for extended release profiles
• Strategic expansions in production capacity to meet rising demand

Get Full Report Here: Global Pharma Grade Hyaluronic Acid API Market – View in Detailed Research Report

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🌍 Outlook: The Future of Pharma Grade Hyaluronic Acid API Is Innovative and Accessible

The pharma grade hyaluronic acid API market is experiencing robust expansion, fueled by advancements in minimally invasive treatments and personalized medicine. While microbial fermentation continues to gain traction for its ethical and scalable advantages, the sector is also investing heavily in next-generation derivatives, regulatory compliance, and global supply chains to address growing therapeutic demands.

📈 Key Trends Shaping the Market:

• Shift toward biofermentation methods in Europe and Asia for sustainability
• Regulatory incentives for HA-based biologics in orthopedics and ophthalmology
• Integration of digital tools for quality control and traceability
• Collaborations between API producers and pharma developers for novel applications

Get Full Report Here: Global Pharma Grade Hyaluronic Acid API Market – View in Detailed Research Report

The companies listed above are not only supplying essential APIs for global healthcare—they’re pioneering the next wave of hyaluronic acid innovations in therapeutics.