The Global Menadione Sodium Bisulfite (MSB) Market was valued at US$ 140 million in 2022 and is projected to reach US$ 200 million by 2029, growing at a Compound Annual Growth Rate (CAGR) of 5.2% during the forecast period (2023–2029). This growth is being driven by expanding livestock and aquaculture sectors, increasing demand for vitamin K supplements in animal feed, and heightened focus on animal health amid regulatory pressures for efficient nutrition solutions in poultry and aquatic farming.

As the animal nutrition industry evolves toward more sustainable and effective feed additives, the emphasis falls on key manufacturers who innovate in production processes, ensure high-quality standards, and meet global demands for procoagulant and nutritional supplements. In this blog, we profile the Top 10 Companies in the Menadione Sodium Bisulfite (MSB) Industry—a blend of established chemical giants, specialized biotech firms, and regional leaders powering advancements in feed and pharmaceutical applications worldwide.

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🔟 1. Brother Enterprises Holding Limited

Headquarters: Ningbo, China
Key Offering: MSB Powder, Pharmaceutical-Grade MSB, Feed-Grade Additives

Brother Enterprises stands as a prominent player in the fine chemicals sector, with a strong emphasis on vitamin precursors like Menadione Sodium Bisulfite. The company supplies high-purity MSB to global feed manufacturers and pharmaceutical firms, leveraging its integrated production facilities to maintain consistent quality and competitive pricing. Its products are widely used in poultry and aquaculture to support blood clotting and overall health, addressing key nutritional deficiencies in intensive farming operations.

Market Contributions:

• Annual production capacity exceeding 1,000 tons of MSB derivatives

• Strategic expansions in Asia-Pacific to meet rising demand from livestock sectors

• Compliance with international standards like ISO and GMP for export markets

Download FREE Sample Report: Menadione Sodium Bisulfite (MSB) Market – View in Detailed Research Report

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9️⃣ 2. DIROX S.A.S.

Headquarters: Bogota, Colombia
Key Offering: MSB for Aquaculture, Poultry Feed Supplements, Custom Formulations

DIROX specializes in animal health products, particularly in Latin America, where it distributes Menadione Sodium Bisulfite for enhancing coagulation in fish and shrimp farming. The company’s focus on sustainable aquaculture solutions has positioned it as a vital supplier in emerging markets, where MSB helps mitigate health issues caused by intensive rearing practices. With a robust distribution network, DIROX ensures timely delivery and technical support to feed millers across South America.

Market Contributions:

• Development of MSB-blended feeds tailored for tropical aquaculture species

• Partnerships with local farms to optimize vitamin K supplementation

• Emphasis on eco-friendly production to align with regional sustainability goals

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8️⃣ 3. OXYVIT (Şişecam Chemicals)

Headquarters: Istanbul, Turkey
Key Offering: Industrial-Grade MSB, Vitamin K3 Equivalents, Bulk Pharmaceutical Intermediates

OXYVIT, under the Şişecam Chemicals umbrella, excels in manufacturing water-soluble vitamin K forms like MSB, serving both European and Middle Eastern markets. The company’s advanced synthesis processes ensure high stability and bioavailability, making its products ideal for injection formulations and feed additives. As global trade dynamics shift, OXYVIT’s strategic location facilitates efficient exports, supporting the nutritional needs of poultry and other livestock in diverse climates.

Market Contributions:

• Investment in R&D for improved MSB solubility in various feed matrices

• Certifications for halal and kosher production to broaden market access

• Supply chain optimizations reducing delivery times to key importers

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7️⃣ 4. Yinhe Chemical Co., Ltd.

Headquarters: Dalian, China
Key Offering: MSB Powder for Feed, Injectable Solutions, Custom Synthesis

Yinhe Chemical is a key contributor to the MSB market, focusing on cost-effective production for the Asian feed industry. Its facilities produce high-volume MSB used primarily in poultry nutrition to prevent hemorrhagic syndromes, with growing applications in pet food. The company’s commitment to quality control has earned it a reputation for reliability, especially as demand surges in China’s vast livestock sector.

Market Contributions:

• Goal to increase MSB output by 20% annually to match domestic growth

• Collaborations with feed giants for integrated vitamin premixes

Download FREE Sample Report: Menadione Sodium Bisulfite (MSB) Market – View in Detailed Research Report

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6️⃣ 5. Yunnan Luliang Peace Technology Co., Ltd.

Headquarters: Luliang, China
Key Offering: Feed-Grade MSB, Aquaculture Additives, Bulk Packaging

Yunnan Luliang Peace Technology specializes in natural and synthetic feed additives, with MSB forming a core part of its portfolio for aquatic animals. Operating in a region rich in raw materials, the company produces stable MSB formulations that enhance immunity and growth in fish farming. Its expansion into Southeast Asia underscores its role in supporting sustainable aquaculture amid rising seafood consumption.

Market Contributions:

• Offers MSB-enriched feeds tested for efficacy in shrimp and salmon production

• Targets expansion into organic feed certifications

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5️⃣ 6. Norkem Limited

Headquarters: Warrington, United Kingdom
Key Offering: Distributed MSB Products, Pharmaceutical MSB, Industrial Applications

Norkem acts as a major distributor of specialty chemicals, including Menadione Sodium Bisulfite, across Europe and beyond. The company sources high-quality MSB from global producers and tailors solutions for the pharmaceutical and feed sectors, ensuring compliance with EU regulations on animal nutrition. Its expertise in logistics enables seamless supply to diverse end-users, from small farms to large integrators.

Market Contributions:

• Current distribution volume supporting over 500 tons annually in Europe

• Target: Enhance supply chain for sustainable sourcing by 2025

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4️⃣ 7. Jiangsu Yong Pharmaceutical and Chemical Co., Ltd.

Headquarters: Nanjing, China
Key Offering: API-Grade MSB Injections, Feed Supplements, Veterinary Formulations

Jiangsu Yong Pharmaceutical bridges the gap between chemical synthesis and veterinary applications, producing MSB for both human and animal use. Its injectable MSB variants are crucial in treating coagulation disorders in livestock, while feed-grade options bolster poultry health. With a focus on innovation, the company invests in greener synthesis methods to reduce environmental impact.

Market Contributions:

• Recent launches of stable MSB injections for rapid veterinary response

• Partnerships with international vets for clinical trials

Download FREE Sample Report: Menadione Sodium Bisulfite (MSB) Market – View in Detailed Research Report

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3️⃣ 8. Guizhou Firstv Biological Technology Co., Ltd.

Headquarters: Guiyang, China
Key Offering: Biological-Enhanced MSB, Poultry Nutrition, Export-Grade Powders

Guizhou Firstv Biological Technology integrates biotech with chemical production, developing enhanced MSB formulations for better absorption in animal feeds. Specializing in poultry applications, the company addresses vitamin K deficiencies exacerbated by modern farming stresses. Its biological approaches ensure higher efficacy, making it a preferred supplier in competitive Asian markets.

Market Contributions:

• Indigenous R&D leading to patented MSB delivery systems

• Collaborations with research institutes for nutrition studies

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2️⃣ 9. Wuhan Xingwang Biological Technology Co., Ltd.

Headquarters: Wuhan, China
Key Offering: High-Purity MSB, Custom Blends for Aquaculture, Pharmaceutical Intermediates

Wuhan Xingwang Biological Technology focuses on precision manufacturing of MSB, catering to the burgeoning aquaculture industry in Asia. Its products prevent bleeding disorders in fish stocks, supporting higher yields in intensive systems. The company’s adherence to strict quality protocols has facilitated entry into North American and European markets, driving export growth.

Market Contributions:

• Aims for 30% increase in aquaculture-specific MSB production

• Major initiatives in supply chain transparency

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1️⃣ 10. Vet-Aqua International

Headquarters: Leeuwarden, Netherlands
Key Offering: Global MSB Distribution, Customized Feed Solutions, Technical Support

Vet-Aqua International leads in distributing specialized additives like MSB worldwide, serving over 1,000 clients in animal health. It specializes in formulating MSB for aquatic and poultry applications, offering end-to-end solutions from sourcing to application advice. As a bridge between manufacturers and users, it plays a pivotal role in global market accessibility and innovation adoption.

Market Contributions:

• End-to-end solutions integrating MSB with other vitamins

• Strategic alliances with producers for just-in-time delivery

Read Full Report: Menadione Sodium Bisulfite (MSB) Market – View in Detailed Research Report

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🌍 Outlook: The Future of Menadione Sodium Bisulfite (MSB) Is Sustainable and Innovative

The Menadione Sodium Bisulfite market is experiencing steady transformation. While traditional powder forms remain dominant, the sector is channeling resources into advanced formulations, regulatory compliance, and expanded applications in sustainable animal farming.

📈 Key Trends Shaping the Market:

• Rapid capacity growth in Asia for feed-grade MSB to feed livestock boom

• Regulatory mandates for vitamin supplementation in animal diets by 2030

• Digital tracking of supply chains for quality and traceability assurance

• Alliances between manufacturers and feed producers for customized nutrition

Read Full Report: Menadione Sodium Bisulfite (MSB) Market – View in Detailed Research Report

The companies listed above are not only supplying essential MSB—they’re spearheading the nutritional evolution in global animal health.