The Global HBTU (CAS 94790-37-1) Market was valued at USD 35.2 Million in 2023 and is projected to reach USD 52.8 Million by 2029, growing at a Compound Annual Growth Rate (CAGR) of 6.1% during the forecast period (2024-2029). This growth is fueled by expanding peptide drug development, increasing pharmaceutical R&D expenditure, and advancements in solid-phase peptide synthesis technologies.

As the pharmaceutical industry shifts toward more complex peptide-based therapeutics, manufacturers of high-purity HBTU (O-Benzotriazole-N,N,N’,N’-tetramethyl-uronium-hexafluoro-phosphate) are becoming increasingly vital to drug development pipelines. This report profiles the Top 10 HBTU Manufacturers worldwide – from specialized peptide chemistry firms to large-scale chemical producers driving innovation in coupling reagent technology.

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🔟 1. Norna Chemical Group

Headquarters: Shijiazhuang, China
Key Offering: Bulk HBTU (98-99% purity), peptide synthesis reagent kits

As one of China’s largest producers of peptide coupling reagents, Norna supplies over 30% of Asia’s HBTU demand through its vertically integrated manufacturing facilities. The company specializes in cost-effective production while maintaining GMP-compliant quality standards.

Production Advantages:

• Annual capacity exceeding 800 metric tons of HBTU and related reagents
• Dedicated peptide chemistry R&D center with 50+ scientists
• CE and ISO 9001 certified production lines

Download FREE Sample Report: HBTU (CAS 94790-37-1) Market – View in Detailed Research Report

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9️⃣ 2. Shanghai Medpep Co., Ltd.

Headquarters: Shanghai, China
Key Offering: Pharmaceutical-grade HBTU, custom peptide services

Shanghai Medpep stands out for its dual expertise in both HBTU production and peptide synthesis services. Their technical teams work closely with pharmaceutical clients to optimize coupling reagent formulations for specific synthesis challenges.

Quality Certifications:

• FDA-registered manufacturing facility
• Strict impurity control (≤0.5% residual solvents)
• Comprehensive stability testing programs

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8️⃣ 3. Bachem AG

Headquarters: Bubendorf, Switzerland
Key Offering: cGMP HBTU, peptide API manufacturing

The Swiss precision chemical manufacturer sets the global standard for pharmaceutical-grade HBTU, supplying over 80% of Top 20 pharma companies. Bachem’s products are integral to commercial peptide drug production worldwide.

Regulatory Leadership:

• USP/EP/JP compliant HBTU
• Full DMF filings available
• Audit-ready documentation packages

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7️⃣ 4. GL Biochem (Shanghai) Ltd.

Headquarters: Shanghai, China
Key Offering: High-purity HBTU, peptide building blocks

With over 20 years in peptide chemistry, GL Biochem manufactures HBTU optimized for both research-scale and production-scale applications. Their technical team provides extensive application support for complex peptide sequences.

Technical Capabilities:

• Chiral purity >99.5% by HPLC
• Moisture-controlled packaging options
• Custom particle size distributions available

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6️⃣ 5. HighFine Biotechnology

Headquarters: Hangzhou, China
Key Offering: HBTU reagent kits, analytical standards

HighFine distinguishes itself through innovative HBTU formulations that reduce racemization in difficult peptide couplings. Their products are widely used in academic research and preclinical drug development.

Innovation Focus:

• Patented stabilization technology
• Mass spectrometry-grade purity
• GMP-like quality systems

Download FREE Sample Report: HBTU (CAS 94790-37-1) Market – View in Detailed Research Report

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5️⃣ 6. Iris Biotech GmbH

Headquarters: Marktredwitz, Germany
Key Offering: European-manufactured HBTU, cGMP materials

The German specialty chemicals firm provides high-purity HBTU to European pharmaceutical companies, with particular focus on clinical-phase materials and commercial API production.

Quality Systems:

• Manufactured under ISO 13485
• Full analytical method validation
• Regulatory support services

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4️⃣ 7. Watanabe Chemical Industries

Headquarters: Osaka, Japan
Key Offering: Ultra-pure HBTU, specialty peptide reagents

As Japan’s leading peptide reagent supplier, Watanabe serves the exacting standards of the Japanese pharmaceutical industry with extremely low-metal content HBTU products.

Purity Standards:

• Heavy metals ≤5 ppm
• Water content ≤0.1%
• Japanese Pharmacopeia compliance

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3️⃣ 8. BioDee BioTech Corporation

Headquarters: Suzhou, China
Key Offering: Research-grade HBTU, contract synthesis

BioDee provides affordable HBTU to academic and biotechnology researchers worldwide, with comprehensive technical data packages for publication support.

Research Focus:

• Batch-specific NMR/HPLC/MS data
• Strict QC for reproducibility
• Small-batch customization

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2️⃣ 9. Haihang Industry Co., Ltd.

Headquarters: Jinan, China
Key Offering: Cost-effective HBTU, chemical distribution

With one of the broadest chemical distribution networks in Asia, Haihang makes HBTU widely accessible to research laboratories and small manufacturers throughout the region.

Supply Chain Advantages:

• Multiple warehouse locations
• Small-quantity availability
• Rapid regional delivery

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1️⃣ 10. NJPeptide Biotechnology

Headquarters: Nanjing, China
Key Offering: Technical-grade HBTU, amino acid derivatives

NJPeptide completes our list with its integrated approach to peptide synthesis reagents, offering HBTU alongside complementary protected amino acids and resins.

Value Proposition:

• One-stop peptide reagent source
• Competitive pricing for bulk orders
• Technical support for scale-up

Get Full Report Here: HBTU (CAS 94790-37-1) Market – View in Detailed Research Report

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🧪 Market Outlook: HBTU in the Evolving Peptide Landscape

The HBTU market is undergoing significant transformation as peptide therapeutics advance through clinical pipelines and manufacturing processes become more sophisticated.

📈 Key Industry Trends:

• Shift toward GMP-grade materials for commercial production
• Increasing purity requirements from regulatory agencies
• Development of more sustainable synthesis routes
• Geographic expansion of peptide manufacturing capacity

Get Full Report Here: HBTU (CAS 94790-37-1) Market – View in Detailed Research Report

The companies profiled here are not merely chemical suppliers – they are critical enablers of modern peptide drug development, ensuring researchers and manufacturers have access to high-performance coupling reagents that meet increasingly stringent quality demands.