The Global R-452a Refrigerant Market was valued at USD 1.28 Billion in 2025 and is projected to reach USD 1.95 Billion by 2034, growing at a Compound Annual Growth Rate (CAGR) of 5.8% during the forecast period (2024–2034). This robust growth is primarily driven by stringent global environmental regulations, such as the Kigali Amendment to the Montreal Protocol, which mandates the phasedown of high Global Warming Potential (GWP) hydrofluorocarbons (HFCs), and the accelerating adoption of low-GWP solutions across commercial refrigeration, air conditioning, and industrial applications.

As the refrigeration and air conditioning (RAC) industry undergoes a significant transformation toward sustainability, the focus intensifies on the key chemical manufacturers and suppliers pioneering next-generation, environmentally friendly refrigerants. In this blog, we profile the Top 10 Companies in the R-452a Refrigerant Industry—a collection of chemical giants and specialized gas producers shaping the future of thermal management.

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🔟 1. Honeywell International Inc.

Headquarters: Charlotte, North Carolina, USA
Key Offering: Solstice® N13 (R-452A), Solstice® zd (R-1233zd)

Honeywell is a global leader in advanced materials and refrigerant technology, with its Solstice® portfolio representing a significant leap in low-GWP solutions. R-452A (Solstice N13) is specifically engineered as a near-drop-in replacement for R-404A and R-507A in commercial refrigeration systems, offering a GWP reduction of approximately 45%.

Sustainability Initiatives:

• Pioneer in hydrofluoroolefin (HFO) technology development

• Committed to reducing the carbon footprint of its products and operations

• Extensive investment in next-generation refrigerant manufacturing capacity

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9️⃣ 2. The Chemours Company

Headquarters: Wilmington, Delaware, USA
Key Offering: Opteon™ XP44 (R-452A), Opteon™ XL series

Chemours is a major force in the refrigerant market with its Opteon™ portfolio, designed to meet stringent environmental regulations without compromising performance. Opteon™ XP44 (R-452A) is a non-ozone depleting HFO blend that provides an efficient and safe alternative for supermarkets, cold storage, and food processing facilities.

Sustainability Initiatives:

• Focus on developing HFO-based products with significantly lower GWP

• Corporate commitment to achieving carbon neutrality by 2050

• Active participation in industry consortia for responsible refrigerant management

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8️⃣ 3. Daikin Industries, Ltd.

Headquarters: Osaka, Japan
Key Offering: R-452A, R-32, and other low-GWP refrigerants

Daikin, a global leader in air conditioning, also produces a range of refrigerants to support its systems and the broader market. The company offers R-452A as part of its strategy to provide sustainable alternatives, leveraging its deep expertise in both equipment design and refrigerant chemistry.

Sustainability Initiatives:

• Promotion of R-32, a lower-GWP refrigerant for air conditioners

• Investment in R&D for next-gen cooling technologies, including natural refrigerants

• Environmental Vision 2050 targeting a net-zero carbon footprint

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7️⃣ 4. Linde plc

Headquarters: Guildford, United Kingdom
Key Offering: R-452A, specialty gas mixtures, bulk refrigerant supply

Linde A.G., now part of Linde plc, is a global industrial gases and engineering giant. The company supplies high-purity R-452A and other fluorinated gases to a vast network of distributors and end-users, supported by its robust logistics and safety standards.

Sustainability Initiatives:

• Leader in providing climate-friendly alternatives across industries

• Commitment to science-based targets for greenhouse gas emissions reduction

• Development of advanced gas recovery and purification services

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6️⃣ 5. Arkema S.A.

Headquarters: Colombes, France
Key Offering: Forane® 452A, Forane® 1234ze, Forane® 1234yf

Arkema’s Fluorogases division is a key player in the European and global refrigerant markets. Its Forane® 452A is part of a comprehensive portfolio of HFOs and HFO blends designed to help customers navigate the HFC phasedown while maintaining system performance and energy efficiency.

Sustainability Initiatives:

• Strong focus on the circular economy through refrigerant reclamation programs

• Innovation in ultra-low GWP fluorinated products

• Alignment of product development with EU F-Gas Regulation and global environmental goals

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R-452aRefrigerant Market – View in Detailed Research Report

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5️⃣ 6. A-Gas International

Headquarters: Bristol, United Kingdom
Key Offering: R-452A supply, refrigerant reclamation, and lifecycle management

A-Gas is a world leader in refrigerant lifecycle management, specializing in the supply, recovery, reclamation, and repurposing of refrigerants. The company is a critical partner for industries transitioning to lower-GWP solutions like R-452A, ensuring a responsible supply chain.

Sustainability Initiatives:

• Global leader in refrigerant reclamation and purification

• Pioneer of “closed-loop” refrigerant management systems

• Rapid Tempo division for the distribution of new, lower-GWP refrigerants

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4️⃣ 7. Tecumseh Products Company (Nidec Global Appliance)

Headquarters: Ann Arbor, Michigan, USA
Key Offering: R-452A compatible compressors, refrigeration units

Tecumseh, now part of Nidec Global Appliance, is a prominent manufacturer of compressors and condensing units for commercial refrigeration. The company actively develops and certifies its products for use with R-452A and other next-generation refrigerants, driving adoption at the equipment level.

Sustainability Initiatives:

• Engineering compressor platforms optimized for low-GWP refrigerants

• Focus on improving overall system energy efficiency

• Support for customers transitioning away from high-GWP fluids

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3️⃣ 8. Koura Global

Headquarters: West Midlands, United Kingdom
Key Offering: R-452A, R-515B, and other fluoroproducts

Koura Global, a wholly-owned subsidiary of Mexichem (now Orbia), is a vertically integrated global producer of fluoroproducts. The company manufactures and supplies R-452A, leveraging its extensive experience in fluorine chemistry and its global production footprint.

Sustainability Initiatives:

• Development of zero-ODP and low-GWP alternatives

• Investment in manufacturing processes that minimize environmental impact

• Active engagement in shaping responsible industry standards

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2️⃣ 9. Orbia Advance Corporation S.A.B. de C.V.

Headquarters: Mexico City, Mexico
Key Offering: Fluorinated gases, polymer solutions, precision agriculture

Orbia’s Fluorinated Solutions business (formerly Mexichem Fluor) is a significant global supplier of refrigerants, including R-452A. The company provides a range of products supporting the HVAC-R industry’s transition, backed by strong R&D capabilities.

Sustainability Initiatives:

• Portfolio diversification toward sustainable solutions

• Commitment to responsible production and product stewardship

• Strategic focus on meeting the demands of evolving environmental regulations

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1️⃣ 10. Climalife (Dehon Group)

Headquarters: Lyon, France
Key Offering: R-452A distribution, technical support, refrigerant management

Climalife is a European specialist in the distribution of refrigerants, heat transfer fluids, and related equipment. The company acts as a key distributor for major producers, providing R-452A and essential technical services to HVAC-R contractors and end-users across the continent.

Sustainability Initiatives:

• Promotion of responsible refrigerant handling and recovery

• Distribution of a wide array of low-GWP and natural refrigerants

• Provision of training and support for safe and efficient transitions

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R-452aRefrigerant Market – View in Detailed Research Report

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🌍 Outlook: The Future of R-452a Refrigerant Is Driven by Regulation and Innovation

The R-452a refrigerant market is at a critical inflection point. While it serves as a vital transitional solution, the industry is simultaneously investing in even lower-GWP alternatives, including HFOs, HFO/HFC blends, and natural refrigerants like CO₂ (R-744) and hydrocarbons.

📈 Key Trends Shaping the Market:

• Accelerated HFC phasedown schedules under the Kigali Amendment and regional regulations like the EU F-Gas Regulation

• Growing demand for energy-efficient cooling solutions in emerging economies with hot climates

• Increasing emphasis on refrigerant lifecycle management, recovery, and reclamation to minimize direct emissions

• Equipment manufacturers designing new systems specifically for A2L (mildly flammable) and low-GWP refrigerants

Get Full Report Here:
R-452aRefrigerant Market – View in Detailed Research Report

The companies listed above are not only supplying essential cooling agents—they are integral to the global effort to decarbonize the refrigeration and air conditioning sector.