The Global Protein Extraction Used HEPES Market was valued at US$ 52.7 Million in 2025 and is projected to reach US$ 86.8 Million by 2034, growing at a Compound Annual Growth Rate (CAGR) of 7.6% during the forecast period (2026–2034). This robust growth is primarily driven by the expanding biotechnology and pharmaceutical sectors, rising R&D investments in proteomics and drug discovery, and the unparalleled utility of HEPES as a stable buffering agent in critical applications such as cell culture, protein purification, and immunoprecipitation.

As life sciences research becomes increasingly precise and dependent on high-quality reagents, the companies supplying the essential HEPES buffer are playing a pivotal role in scientific advancement. In this blog, we profile the Top 10 Companies in the Protein Extraction Used HEPES Industry—a group of chemical suppliers, life science giants, and specialized manufacturers ensuring the integrity and reproducibility of biological research worldwide.

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Protein Extraction Used HEPES Market – View in Detailed Research Report

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🔟 1. VWR International, LLC (Part of Avantor)

Headquarters: Radnor, Pennsylvania, USA
Key Offering: HEPES Powder, HEPES Solution, and custom buffer formulations

VWR, a cornerstone of the global life sciences supply chain under the Avantor umbrella, is a leading distributor of HEPES buffers. The company provides high-purity, cell culture-tested HEPES products that are critical for maintaining pH stability during protein extraction and purification processes across academic, pharmaceutical, and industrial laboratories.

Key Innovations & Offerings:

• Broad portfolio of cGMP-grade and research-grade HEPES buffers

• Integrated supply chain solutions for biopharmaceutical manufacturing

• Global distribution network supporting rapid delivery to research hubs

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9️⃣ 2. ANGUS Chemical Company (Subsidiary of Dow Inc.)

Headquarters: Buffalo Grove, Illinois, USA
Key Offering: TRIS AMINO® and HEPES-based buffering agents

ANGUS Chemical Company, a global leader in specialty chemicals, is renowned for its high-quality buffer components. Known for its technical expertise in optimizing chemical processes, ANGUS supplies pure and reliable HEPES that meets the stringent requirements of protein biochemistry and diagnostic assay development.

Key Innovations & Offerings:

• Focus on high-purity, low-endotoxin HEPES for sensitive biological applications

• Strong commitment to quality control and regulatory compliance

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8️⃣ 3. MP Biomedicals

Headquarters: Irvine, California, USA
Key Offering: HEPES Powder, HEPES Buffer Solutions, Life Science Reagents

MP Biomedicals specializes in providing life science and diagnostics products, with a comprehensive range of biochemicals including HEPES buffer. Their products are widely used in protein extraction protocols, cell-based assays, and molecular biology applications, favored for their consistency and reliability.

Key Innovations & Offerings:

• Extensive catalog of reagents for genomics, proteomics, and cell biology

• Manufacturing facilities adhering to international quality standards (ISO)

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7️⃣ 4. Merck KGaA

Headquarters: Darmstadt, Germany
Key Offering: HEPES Ultra-Pure, Millipore® HEPES Buffers

Merck, a global science and technology leader, offers a premium portfolio of HEPES products through its MilliporeSigma brand. These high-purity buffers are essential tools in laboratories conducting protein research, bioprocessing, and pharmaceutical development, ensuring minimal interference in sensitive experimental outcomes.

Key Innovations & Offerings:

• Ultra-pure HEPES formulations for critical bioprocessing applications

• Integrated solutions combining buffers with filtration and purification technologies

Download FREE Sample Report:
Protein Extraction Used HEPES Market – View in Detailed Research Report

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6️⃣ 5. Sepmag (Part of Solvias AG)

Headquarters: Barcelona, Spain
Key Offering: HEPES Buffers, magnetic bead-based separation systems

Sepmag, now part of Solvias, is known for its innovative biomagnetic separation technologies. While their core expertise is in instrumentation, they supply compatible high-quality HEPES buffers used in conjugation and purification workflows, particularly those involving magnetic beads for protein isolation.

Key Innovations & Offerings:

• Synergistic offering of buffers and proprietary separation platforms

• Focus on automation and scalability for biomanufacturing

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5️⃣ 6. IBA Lifesciences GmbH

Headquarters: Göttingen, Germany
Key Offering: HEPES for protein labeling, purification kits

IBA Lifesciences is a specialist in protein analysis and purification technologies. The company provides HEPES buffers optimized for specific applications like protein-protein interaction studies, immunoprecipitation, and Strep-tag® purification systems, catering to the needs of advanced proteomics researchers.

Key Innovations & Offerings:

• Application-specific buffer formulations for maximum protein stability

• Proprietary technologies for gentle and efficient protein handling

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4️⃣ 7. Cytiva

Headquarters: Marlborough, Massachusetts, USA
Key Offering: HEPES Buffers, chromatography resins, bioprocessing consumables

Cytiva is a global provider of technologies and services that advance and accelerate the development and manufacture of therapeutics. Their high-quality HEPES buffers are integral to downstream bioprocessing, particularly in chromatography steps for monoclonal antibody and recombinant protein purification.

Key Innovations & Offerings:

• Buffers compatible with large-scale Good Manufacturing Practice (GMP) production

• End-to-end solutions from discovery to commercial manufacturing

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3️⃣ 8. Takara Bio Inc.

Headquarters: Kusatsu, Shiga, Japan
Key Offering: HEPES Buffers, cell culture reagents, molecular biology kits

Takara Bio is a leading Japanese biotechnology company with a strong focus on research reagents. Their HEPES products are trusted in academic and industrial settings across Asia and globally for applications in cell culture maintenance, protein extraction from delicate cell lines, and various biochemical assays.

Key Innovations & Offerings:

• High-quality reagents supporting innovative gene and cell therapy research

• Strong presence and distribution network in the rapidly growing Asian market

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2️⃣ 9. Bio Basic Inc.

Headquarters: Markham, Ontario, Canada
Key Offering: Cost-effective HEPES Powder and Solution, OEM services

Bio Basic is a major manufacturer and distributor of life science reagents, known for providing high-value products. The company offers competitively priced, high-purity HEPES buffer, making essential research tools more accessible to a broader range of laboratories and educational institutions worldwide.

Key Innovations & Offerings:

• Focus on affordability without compromising on purity and performance

• Extensive OEM and custom formulation services for bulk requirements

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1️⃣ 10. STEMCELL Technologies

Headquarters: Vancouver, British Columbia, Canada
Key Offering: HEPES-containing media, specialized cell culture reagents

STEMCELL Technologies is a leading developer and manufacturer of cell culture media, cell separation technologies, and ancillary reagents. While not a primary chemical supplier, the company integrates high-quality HEPES buffer into its proprietary media formulations used for stem cell research, organoid culture, and primary cell isolation, where precise pH control is paramount.

Key Innovations & Offerings:

• Specialized media containing HEPES for demanding cell culture applications

• Rigorous quality control to ensure lot-to-lot consistency for critical research

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Protein Extraction Used HEPES Market – View in Detailed Research Report

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🔬 Outlook: The Future of Protein Extraction is Precision and Scalability

The Protein Extraction Used HEPES market is evolving in tandem with the life sciences industry’s push towards more reproducible, high-throughput, and translationally relevant research. While HEPES remains a fundamental tool, its application is becoming more sophisticated, integrated into automated systems and scalable bioprocesses.

📈 Key Trends Shaping the Market:

• Growing demand for GMP-grade buffers to support the booming biopharmaceutical pipeline

• Integration of HEPES into ready-to-use formulations and kit-based assays for workflow efficiency

• Rising focus on supply chain resilience and regional manufacturing capabilities post-pandemic

• Increased investment in proteomics and personalized medicine, driving reagent demand

Get Full Report Here:
Protein Extraction Used HEPES Market – View in Detailed Research Report

The companies profiled above are not just suppliers of a chemical buffer; they are enablers of scientific discovery, providing the foundational tools that ensure the accuracy and success of research that leads to new diagnostics, therapies, and a deeper understanding of biology.