The Global Desalting and Buffer Exchange Resins Market was valued at USD 528.3 Million in 2025 and is projected to reach USD 896.7 Million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 7.8% during the forecast period (2025–2032). This robust growth is being driven by expanding biopharmaceutical production, increasing adoption of single-use technologies, and stricter regulatory requirements for drug purity, particularly for advanced therapies like monoclonal antibodies and mRNA vaccines.

As the bioprocessing and water treatment industries demand higher purity and efficiency, the focus intensifies on the key resin manufacturers who are advancing separation science. In this blog, we profile the Top 10 Companies in the Desalting and Buffer Exchange Resins Industry—a mix of global chemical giants, specialty manufacturers, and technology innovators shaping the future of purification.

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🔟 1. Cytiva

Headquarters: Marlborough, Massachusetts, USA
Key Offering: Sephadex™, Capto™, and HiTrap™ Desalting Columns

Cytiva is a world leader in bioprocessing technologies, providing a comprehensive portfolio of desalting and buffer exchange resins used extensively in downstream purification. Their products are essential for protein purification, buffer exchange, and salt removal in biopharmaceutical manufacturing. Recent investments, including a USD 50 million expansion of resin production capacity in Massachusetts, underscore their commitment to meeting global demand.

Innovation Initiatives:

• Development of high-flow agarose-based resins for faster processing
• Expansion of pre-packed column offerings for single-use systems
• Focus on resins tailored for monoclonal antibody and vaccine purification

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Desalting and Buffer Exchange Resins Market – View in Detailed Research Report

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9️⃣ 2. DuPont

Headquarters: Wilmington, Delaware, USA
Key Offering: AmberChrom™, AmberLite™, and DuPont™ Water Solutions resins

DuPont offers a wide array of ion exchange and reverse phase chromatography resins under its Water Solutions and Life Sciences divisions. Their products are critical for industrial water treatment, pharmaceutical purification, and food and beverage processing. DuPont’s strong R&D focus drives innovations in resin durability and selectivity.

Innovation Initiatives:

• Advancements in mixed-bed ion exchange resins for ultra-pure water
• Development of resins for challenging separations in biologics
• Sustainability programs focused on reducing water and chemical usage in regeneration

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8️⃣ 3. Purolite

Headquarters: Bala Cynwyd, Pennsylvania, USA
Key Offering: Life Sciences and Industrial Grade Ion Exchange Resins

Purolite is a leading manufacturer of ion exchange, adsorbent, and catalyst resins, with a significant presence in the pharmaceutical and biotechnology sectors. The company is known for its high-purity resins that meet stringent regulatory standards for drug manufacturing. Their global manufacturing footprint ensures a reliable supply chain.

Innovation Initiatives:

• Specialized resins for pharmaceutical synthesis and purification
• Focus on producing resins with extremely low extractables and leachables
• Expansion of manufacturing capacity in Europe and Asia

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7️⃣ 4. Lanxess

Headquarters: Cologne, Germany
Key Offering: Lewatit® Ion Exchange Resins

Lanxess is a major global supplier of ion exchange resins, with its Lewatit® brand being highly recognized in both water treatment and life sciences applications. The company provides resins for desalination, softening, and purification processes across various industries, leveraging strong German engineering and chemical expertise.

Innovation Initiatives:

• Development of high-capacity resins for specific ion removal
• Investment in sustainable resin technologies with longer lifespans
• Focus on customized solutions for industrial wastewater treatment

Download FREE Sample Report:
Desalting and Buffer Exchange Resins Market – View in Detailed Research Report

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6️⃣ 5. Mitsubishi Chemical Corporation

Headquarters: Tokyo, Japan
Key Offering: Diaion™ and Relite™ Resins

Mitsubishi Chemical is a key player in the Asia-Pacific region, offering a diverse range of separation and purification resins. Their Diaion™ line is widely used in the pharmaceutical industry for desalting, buffer exchange, and chromatographic separations. The company benefits from strong regional demand and a focus on high-quality manufacturing.

Innovation Initiatives:

• R&D in multimodal chromatography resins for complex separations
• Expansion of product lines for bio-based chemical production
• Development of resins resistant to organic solvents and extreme pH conditions

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5️⃣ 6. Thermo Fisher Scientific

Headquarters: Waltham, Massachusetts, USA
Key Offering: Pierce™ Desalting Columns, Zeba™ Spin Desalting Columns

Thermo Fisher Scientific provides essential tools for life sciences research and bioproduction, including a range of ready-to-use desalting columns. Their products are designed for laboratory-scale protein purification and buffer exchange, offering convenience and reproducibility for researchers. Their integration with other bioprocessing tools creates a comprehensive workflow solution.

Innovation Initiatives:

• Development of high-recovery spin columns for precious samples
• Focus on scalability from research to production
• Integration with automated liquid handling systems

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4️⃣ 7. Merck KGaA

Headquarters: Darmstadt, Germany
Key Offering: MilliporeSigma chromatography resins and membranes

Through its MilliporeSigma business, Merck KGaA is a significant supplier of purification products, including desalting and buffer exchange resins. The company serves the entire bioprocessing workflow, from discovery to large-scale manufacturing, with a strong emphasis on quality and compliance.

Innovation Initiatives:

• Investment in continuous chromatography technologies
• Development of resins for next-generation biologics like cell and gene therapies
• Focus on enhancing resin capacity and lifetime

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3️⃣ 8. Bio-Rad Laboratories

Headquarters: Hercules, California, USA
Key Offering: Bio-Gel® P desalting gels, Econo-Pac® chromatography columns

Bio-Rad Laboratories is a well-established provider of life science research and clinical diagnostic products. Their Bio-Gel® P polyacrylamide gels are a classic tool for desalting and buffer exchange of proteins and nucleic acids. The company has a strong presence in academic and industrial research laboratories worldwide.

Innovation Initiatives:

• Modernization of traditional resin products for improved performance
• Development of kits and pre-packed columns for specific applications
• Support for proteomics and genomics research workflows

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2️⃣ 9. ResinTech

Headquarters: Cherry Hill, New Jersey, USA
Key Offering: Water Treatment and Specialty Ion Exchange Resins

ResinTech is a specialized manufacturer of ion exchange resins, focusing on water treatment, pharmaceutical, and industrial applications. The company is known for providing cost-effective alternatives to major brands and for its ability to customize resins for specific customer needs. They play a significant role in the North American market.

Innovation Initiatives:

• Custom synthesis of specialty resins for niche applications
• Focus on regenerable resins to reduce long-term operational costs
• Expansion into pharmaceutical-grade resin manufacturing

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1️⃣ 10. Samyang Corporation

Headquarters: Seoul, South Korea
Key Offering: Chromatography resins and separation media

Samyang is a leading chemical company in South Korea with a growing presence in the chromatography resins market. The company produces a range of ion exchange and size exclusion resins used in biopharmaceutical purification and industrial separations. Samyang benefits from the rapidly expanding biotech sector in Asia.

Innovation Initiatives:

• Development of high-performance resins for biosimilar production
• Investment in green chemistry for resin manufacturing
• Strategic partnerships with biopharmaceutical companies in the Asia-Pacific region

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Desalting and Buffer Exchange Resins Market – View in Detailed Research Report

📈 Key Trends Shaping the Market:

• Rising demand for pre-packed and single-use columns to minimize contamination risk and reduce validation time
• Development of high-capacity, high-flow-rate resins to improve bioprocessing efficiency and throughput
• Increasing regulatory scrutiny on extractables and leachables, driving demand for ultra-pure resin formulations
• Growing adoption in non-traditional applications such as mRNA vaccine production and gene therapy

Get Full Report Here:
Desalting and Buffer Exchange Resins Market – View in Detailed Research Report

The companies listed above are not only supplying critical purification tools—they’re advancing the efficiency and sustainability of biomanufacturing and water treatment worldwide.