The Global Soluble Silk Fibroin Powder Market was valued at USD 115 Million in 2025 and is projected to reach USD 261 Million by 2034, growing at a Compound Annual Growth Rate (CAGR) of 12.5% during the forecast period. This robust growth is being driven by the increasing global preference for natural, safe, and high-performance ingredients in cosmetics and biomedicine, alongside the expanding application of biodegradable protein materials in advanced fields like tissue engineering and 3D bioprinting.

As industries pivot towards sustainable and biocompatible solutions, the spotlight turns to the key manufacturers pioneering the extraction and application of this remarkable natural polymer. In this blog, we profile the Top 10 Companies in the Soluble Silk Fibroin Powder Industry—a dynamic mix of biotechnology innovators, specialized manufacturers, and research-driven firms shaping the future of biomaterials.

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🔟 1. Advanced BioMatrix, Inc.

Headquarters: Carlsbad, California, USA
Key Offering: High-Purity Medical and Research-Grade Silk Fibroin Powder

Advanced BioMatrix is a leading supplier of high-quality, soluble silk fibroin powder specifically designed for demanding biomedical and research applications. The company’s products are renowned for their exceptional purity, consistency, and biocompatibility, making them a preferred choice for tissue engineering, 3D cell culture, and drug delivery research.

Innovation & Specialty:

• Focus on GMP-compatible and endotoxin-tested grades for clinical applications

• Extensive support and technical data for researchers

• Strategic partnerships with academic institutions and biotech firms

Download FREE Sample Report:
Soluble Silk Fibroin Powder Market – View in Detailed Research Report

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9️⃣ 2. Biosynth

Headquarters: Staad, Switzerland
Key Offering: Research-grade and Customizable Silk Fibroin Powder

Biosynth is a global life sciences supplier providing high-purity soluble silk fibroin powder to the pharmaceutical and biotechnology sectors. The company offers both standard and custom-configured powders with specific molecular weights and solubility profiles to meet unique research and development needs.

Innovation & Specialty:

• Expertise in custom synthesis and modification of biomaterials

• Supply chain reliability for global research and development

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8️⃣ 3. Huzhou Aotesi Biochemical Co., Ltd.

Headquarters: Huzhou, Zhejiang, China
Key Offering: Cosmetic and Industrial-Grade Silk Fibroin Powder

Huzhou Aotesi Biochemical is a major Chinese manufacturer leveraging its proximity to raw silk production hubs. The company specializes in producing cost-effective, high-volume soluble silk fibroin powder primarily for the cosmetic and personal care industry, with a growing focus on industrial applications.

Innovation & Specialty:

• Vertically integrated production from raw silk sourcing

• Competitive pricing for large-scale industrial users

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7️⃣ 4. Cocoon Biotech

Headquarters: Bengaluru, India
Key Offering: Enzymatically Hydrolyzed Silk Fibroin Powder

Cocoon Biotech is an emerging innovator focusing on enzymatic hydrolysis to produce soluble silk fibroin powder with enhanced bioactivity and controlled molecular weight. Their technology platform is geared towards advanced biomedical applications, including wound healing and regenerative medicine.

Innovation & Specialty:

• Proprietary enzymatic process for superior powder quality

• Strong R&D focus on novel drug delivery systems

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6️⃣ 5. Kelisema Srl

Headquarters: Bologna, Italy
Key Offering: Premium Cosmetic and Nutraceutical-Grade Silk Fibroin Powder

Kelisema is an Italian company dedicated to producing high-value soluble silk fibroin powder for the European cosmetic and nutraceutical markets. Their products are characterized by high purity and are marketed as a key active ingredient for anti-aging and moisturizing formulations.

Innovation & Specialty:

• Emphasis on natural and sustainable ingredient sourcing

• Compliance with European COSMOS and other organic standards

Download FREE Sample Report:
Soluble Silk Fibroin Powder Market – View in Detailed Research Report

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5️⃣ 6. Seidecosa

Headquarters: Berlin, Germany
Key Offering: Medical and Cosmetic-Grade Silk Fibroin Powders

Seidecosa is a German specialist in silk-derived biomaterials, offering a range of soluble silk fibroin powders. The company caters to both the high-end cosmetic industry, providing ingredients for luxury skincare, and the biomedical sector, supplying materials for research and development.

Innovation & Specialty:

• Rigorous quality control for batch-to-batch consistency

• Focus on dermatologically tested ingredients for sensitive skin

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4️⃣ 7. Fibroheal

Headquarters: Hyderabad, India
Key Offering: Advanced Wound Care-focused Silk Fibroin Powder

Fibroheal is an Indian biotechnology company that develops advanced wound care products, with soluble silk fibroin powder being a core material. Their expertise lies in creating powders optimized for hydrogel formulations that promote healing and tissue regeneration.

Innovation & Specialty:

• Application-specific development for wound dressings

• Collaborations with clinical research organizations

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3️⃣ 8. Caresilk

Headquarters: Seoul, South Korea
Key Offering: Nano-grade and Cosmetic Silk Fibroin Powder

Caresilk is a South Korean manufacturer known for its advanced processing techniques that produce nano-grade soluble silk fibroin powder. This powder offers superior solubility and penetration, making it ideal for high-efficacy cosmetic serums and advanced topical drug formulations.

Innovation & Specialty:

• Specialization in nano-technology for enhanced bioavailability

• Strong presence in the innovative K-beauty supply chain

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2️⃣ 9. Hangzhou Linran Biotechnology Co., Ltd.

Headquarters: Hangzhou, Zhejiang, China
Key Offering: Broad Portfolio of Cosmetic and Food-Grade Powders

Hangzhou Linran is a significant Chinese producer with a diverse portfolio of soluble silk fibroin powders. The company supplies various grades to the cosmetic, food, and pharmaceutical industries, emphasizing scalability and competitive pricing.

Innovation & Specialty:

• Diversified product range catering to multiple industries

• Investment in scaling production capacity to meet global demand

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1️⃣ 10. Xi’an Sost Biotech Co., Ltd.

Headquarters: Xi’an, Shaanxi, China
Key Offering: Food, Cosmetic, and Pharmaceutical-Grade Powders

Xi’an Sost Biotech is a versatile manufacturer supplying soluble silk fibroin powder for nutraceutical, cosmetic, and pharmaceutical applications. The company is actively exploring the use of silk fibroin as a functional protein ingredient in health foods and supplements.

Innovation & Specialty:

• Pioneering research into silk fibroin for nutraceuticals

• Focus on developing tasteless and odorless food-grade powders

Get Full Report Here:
Soluble Silk Fibroin Powder Market – View in Detailed Research Report

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🧬 Outlook: The Future of Soluble Silk Fibroin Powder is High-Performance and Multi-Functional

The soluble silk fibroin powder market is undergoing a significant transformation. While traditional cosmetic applications continue to drive volume, the industry is heavily investing in advanced biomedical applications, purification technologies, and novel food-grade formulations.

📈 Key Trends Shaping the Market:

• R&D expansion into 3D bioprinting bio-inks and regenerative medicine

• Growing demand for clean-label, natural ingredients in cosmetics and food

• Technological advancements in enzymatic hydrolysis and nano-sizing

• Strategic partnerships between biotech firms and end-user industries

Get Full Report Here:
Soluble Silk Fibroin Powder Market – View in Detailed Research Report

The companies listed above are not only supplying a versatile biomaterial—they’re pioneering the integration of nature’s wisdom into modern science for a healthier and more sustainable future.