The Global Casein Hydrolase Market was valued at USD 245.8 Million in 2023 and is projected to reach USD 385.2 Million by 2030, growing at a Compound Annual Growth Rate (CAGR) of 6.7% during the forecast period (2024–2030). This significant growth is fueled by the escalating demand for protein hydrolysates in functional foods, the rising consumer preference for bioactive ingredients in cosmetics, and the expanding applications within the pharmaceutical industry for improved nutrient absorption and therapeutic peptides.

As industries increasingly pivot toward natural and efficient enzymatic processes, the companies producing high-quality casein hydrolase are becoming pivotal to innovation. These enzymes, which specifically break down casein protein found in milk, are critical for creating value-added products. In this blog, we profile the Top 10 Companies in the Casein Hydrolase Industry—a collection of specialized enzyme manufacturers and biotech innovators driving the future of biocatalysis.

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🔟 1. Novozymes A/S

Headquarters: Bagsværd, Denmark
Key Offering: Neutrase®, FoodPro® range of proteases

Novozymes is a global leader in biological solutions, with a dominant position in the enzyme market. Their extensive portfolio includes highly specific proteases suitable for casein hydrolysis, serving the food, beverage, and dietary supplement industries with a focus on yield, purity, and process efficiency.

Innovation and Sustainability Initiatives:

• Continuous R&D in microbial fermentation for high-activity enzymes

• Commitment to reducing water and energy consumption in manufacturing processes

• Partnerships with dairy processors to develop tailored hydrolysis solutions

Download FREE Sample Report:
Casein Hydrolase Market – View in Detailed Research Report

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9️⃣ 2. Chr. Hansen Holding A/S

Headquarters: Hørsholm, Denmark
Key Offering: Food Ingredients & Enzymes division

A major player in bioscience, Chr. Hansen provides natural ingredient solutions, including a range of enzymes for the dairy sector. Their expertise in microbial technology positions them as a key supplier of proteolytic enzymes for producing casein hydrolysates with specific functional and nutritional properties.

Innovation and Sustainability Initiatives:

• Focus on non-GMO and clean-label enzyme solutions

• Development of enzymes that operate under mild conditions to preserve nutrient quality

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8️⃣ 3. DuPont de Nemours, Inc. (Danisco)

Headquarters: Wilmington, Delaware, USA
Key Offering: Danisco® Protease enzymes

Through its Danisco subsidiary, DuPont offers a robust portfolio of food enzymes, including proteases specifically designed for dairy protein hydrolysis. Their enzymes are engineered for consistency and performance in industrial-scale applications, from infant formula to sports nutrition.

Innovation and Sustainability Initiatives:

• Advanced protein engineering for enzyme specificity and stability

• Investment in sustainable production methods and circular economy principles

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7️⃣ 4. Amano Enzyme Inc.

Headquarters: Nagoya, Japan
Key Offering: Amano Microbial Proteases

Amano Enzyme is a Japanese specialist with a global presence, renowned for its high-purity microbial enzymes. The company provides specific proteases that effectively hydrolyze casein, catering to the stringent quality requirements of the pharmaceutical and high-end food industries.

Innovation and Sustainability Initiatives:

• Focus on developing enzymes for allergen reduction in dairy products

• Commitment to ISO-certified manufacturing and quality control

Download FREE Sample Report:
Casein Hydrolase Market – View in Detailed Research Report

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6️⃣ 5. Advanced Enzyme Technologies Ltd.

Headquarters: Mumbai, India
Key Offering: A range of digestive and specialty enzymes

A leading Indian enzyme company, Advanced Enzyme Technologies develops and manufactures enzymes for various sectors. Their expertise includes proteases for dairy applications, serving both domestic and international markets with cost-effective and efficient hydrolysis solutions.

Innovation and Sustainability Initiatives:

• Strong R&D focus on thermostable enzymes for broader application ranges

• Expansion of manufacturing capacity to meet growing global demand

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5️⃣ 6. Specialty Enzymes & Probiotics

Headquarters: Chino, California, USA
Key Offering: Custom enzyme blends and specialty proteases

This US-based company specializes in developing custom enzyme formulations. They offer proteases suitable for casein hydrolysis, with applications spanning dietary supplements, functional foods, and industrial processes, emphasizing product customization and technical support.

Innovation and Sustainability Initiatives:

• Specialization in allergen-free and kosher-certified enzyme products

• Development of synergistic enzyme blends for enhanced hydrolysis efficiency

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4️⃣ 7. Creative Enzymes

Headquarters: Shirley, New York, USA
Key Offering: High-purity research-grade and industrial enzymes

Creative Enzymes is a prominent supplier for both research institutions and industrial clients. They provide a wide array of casein hydrolase products, including highly specific proteases from microbial and animal sources, supporting innovation in R&D and pilot-scale production.

Innovation and Sustainability Initiatives:

• Extensive catalog supporting academic and pharmaceutical research

• Focus on providing enzymes with detailed characterization data and protocols

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3️⃣ 8. Enzyme Development Corporation

Headquarters: New York, New York, USA
Key Offering: Specialty enzyme solutions for food processing

With over 70 years of experience, Enzyme Development Corporation is a key supplier of enzymes to the North American market. They offer proteases tailored for the dairy industry, helping manufacturers improve texture, flavor, and functionality of protein hydrolysates.

Innovation and Sustainability Initiatives:

• Expertise in application-specific enzyme sourcing and blending

• Long-standing partnerships with food manufacturers for process optimization

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2️⃣ 9. HBI Enzymes Inc.

Headquarters: Ahmedabad, India
Key Offering: Industrial-grade enzymes

HBI Enzymes is an emerging Indian manufacturer producing a range of enzymes for various industries. Their protease products are used in dairy processing for casein hydrolysis, offering competitive pricing and reliable performance for cost-sensitive markets.

Innovation and Sustainability Initiatives:

• Investment in scaling up production to serve export markets

• Focus on developing enzymes suitable for local raw material profiles

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1️⃣ 10. MetGen Oy

Headquarters: Kaarina, Finland
Key Offering: METNIN™ enzyme technology platform

MetGen is a Finnish biotechnology company specializing in engineering enzymes for industrial processes. While known for biomass conversion, their protein engineering expertise is being applied to develop novel proteases with unique properties for specialized dairy and pharmaceutical applications.

Innovation and Sustainability Initiatives:

• Pioneering work in enzyme engineering for non-conventional reaction conditions

• Collaborations with research institutes to explore new enzyme functionalities

Get Full Report Here:
Casein Hydrolase Market – View in Detailed Research Report

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🔬 Outlook: The Future of Casein Hydrolase Is Precision and Personalization

The casein hydrolase market is evolving from a bulk ingredient supplier model toward a highly specialized, solution-oriented industry. The focus is shifting to enzyme precision, sustainability, and creating hydrolysates with targeted bioactivities for specific health and functional benefits.

📈 Key Trends Shaping the Market:

• Rise of personalized nutrition driving demand for specific peptide profiles

• Increased use of bioinformatics and AI in enzyme discovery and optimization

• Growing regulatory emphasis on enzyme safety and clean-label certifications

• Expansion into cosmetic applications for anti-aging and skin-health products

Get Full Report Here:
Casein Hydrolase Market – View in Detailed Research Report

The companies leading this market are not just selling enzymes—they are enabling the creation of next-generation bioactive ingredients that enhance health, wellness, and product performance across multiple industries.