The Global Protocatechuic Acid (CAS 99-50-3) Market was valued at USD 12.3 million in 2024 and is projected to grow from USD 12.8 million in 2025 to USD 16 million by 2032, exhibiting a Compound Annual Growth Rate (CAGR) of 3.9% during the forecast period (2024–2032). This steady expansion is primarily driven by the compound’s potent antioxidant and anti-inflammatory properties, which are fueling its adoption across pharmaceutical formulations, functional foods, and advanced cosmetic applications.

As the healthcare and wellness industries increasingly pivot toward natural and plant-derived bioactive compounds, the spotlight is on the key suppliers who are scaling production, advancing extraction technologies, and pioneering new applications for this versatile phenolic acid. In this blog, we profile the Top 10 Companies in the Protocatechuic Acid Industry—a mix of established chemical manufacturers and specialized botanical extract producers shaping the future of this niche but rapidly evolving market.

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🔟 10. Shaanxi Huike Botanical Development Co., Ltd.

Headquarters: Xi’an, Shaanxi, China
Key Offering: Plant-Extracted Protocatechuic Acid, Botanical Raw Materials

Shaanxi Huike Botanical Development specializes in the extraction of active compounds from traditional Chinese medicinal plants. The company leverages the rich botanical resources of the Shaanxi region to produce high-purity Protocatechuic Acid, primarily for the nutraceutical and traditional medicine sectors.

Key Strengths and Initiatives:

• Specialization in green tea and hibiscus extracts as primary PCA sources

• Strong focus on sustainable and traceable sourcing practices

• Expanding partnerships with European and North American supplement brands

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9️⃣ 9. Kingherbs Limited

Headquarters: Xi’an, Shaanxi, China
Key Offering: Protocatechuic Acid, Standardized Herbal Extracts

Kingherbs Limited is a recognized supplier of standardized herbal extracts, with Protocatechuic Acid being one of its key high-value products. The company serves a global clientele in the dietary supplement and functional food industries.

Key Strengths and Initiatives:

• Advanced quality control systems ensuring batch-to-batch consistency

• Investment in research to identify new plant sources for PCA

• Certifications including ISO 9001 and Halal, facilitating international trade

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8️⃣ 8. Hangzhou Hyper Chemicals Limited

Headquarters: Hangzhou, Zhejiang, China
Key Offering: Synthetic and Natural Protocatechuic Acid

Hangzhou Hyper Chemicals operates as a versatile supplier, offering both chemically synthesized and plant-extracted Protocatechuic Acid. This dual approach allows them to cater to diverse customer needs, from cost-sensitive industrial applications to high-purity pharmaceutical requirements.

Key Strengths and Initiatives:

• Flexible production capabilities to meet varying purity specifications

• Strategic location in a major Chinese chemical industry hub

• Focus on developing more efficient catalytic synthesis processes

Download FREE Sample Report: Protocatechuic Acid (CAS 99-50-3) Market – View in Detailed Research Report

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7️⃣ 7. Hunan NutraMax Inc.

Headquarters: Changsha, Hunan, China
Key Offering: Nutraceutical-Grade Protocatechuic Acid

Hunan NutraMax focuses primarily on serving the nutraceutical industry with high-quality, plant-derived active ingredients. The company has built a reputation for reliable supply and rigorous quality standards for its Protocatechuic Acid products.

Key Strengths and Initiatives:

• Specialization in ingredients for metabolic health and antioxidant formulations

• Ongoing investment in laboratory facilities for analytical testing

• Active participation in industry trade shows to build global networks

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6️⃣ 6. Jiangsu Panson Extraction Technology Co.

Headquarters: Nanjing, Jiangsu, China
Key Offering: Protocatechuic Acid, Custom Extraction Services

Jiangsu Panson Extraction Technology stands out for its focus on advanced extraction technologies, including supercritical CO2 and ultrasonic-assisted extraction. The company offers both standard Protocatechuic Acid products and custom extraction services for specific client requirements.

Key Strengths and Initiatives:

• Proprietary extraction technologies yielding higher purity levels

• Strong R&D focus on improving yield and reducing solvent use

• Collaborations with academic institutions on bioactive compound research

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5️⃣ 5. Aktin Chemicals, Inc.

Headquarters: Xi’an, Shaanxi, China
Key Offering: High-Purity Protocatechuic Acid, Pharmaceutical Intermediates

Aktin Chemicals has established itself as a key supplier of high-purity Protocatechuic Acid, particularly for pharmaceutical and research applications. The company’s stringent quality control processes make it a preferred partner for demanding end-use sectors.

Key Strengths and Initiatives:

• Manufacturing facilities compliant with GMP standards

• Significant export business to North America and Europe

• Investment in scaling up production to meet growing pharmaceutical demand

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4️⃣ 4. Henan Lyle Wormwood Industrial Co., Ltd.

Headquarters: Zhengzhou, Henan, China
Key Offering: Botanical Protocatechuic Acid, Artemisia Extract

Henan Lyle Wormwood leverages its expertise in wormwood and other medicinal plant extracts to produce Protocatechuic Acid. The company controls its supply chain from cultivation to extraction, ensuring quality and sustainability.

Key Strengths and Initiatives:

• Vertical integration with contracted farms for raw material security

• Development of proprietary extraction methods for higher yields

• Expanding product portfolio to include PCA derivatives for specialized applications

Download FREE Sample Report: Protocatechuic Acid (CAS 99-50-3) Market – View in Detailed Research Report

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3️⃣ 3. Xi’an Season Biotechnology Co., Ltd.

Headquarters: Xi’an, Shaanxi, China
Key Offering: Protocatechuic Acid, Natural Plant Extracts

Xi’an Season Biotechnology is a prominent player in the plant extract industry, with a diverse portfolio that includes high-quality Protocatechuic Acid. The company’s strong R&D focus drives innovation in both product development and application testing.

Key Strengths and Initiatives:

• Comprehensive product testing for purity and biological activity

• Strategic focus on high-growth application areas like cosmeceuticals

• Investment in automation to improve production efficiency and consistency

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2️⃣ 2. Taizhou Zhongda Chemical Co., Ltd.

Headquarters: Taizhou, Jiangsu, China
Key Offering: Synthetic Protocatechuic Acid, Chemical Intermediates

Taizhou Zhongda Chemical is one of the leading producers of synthetically derived Protocatechuic Acid, leveraging cost-effective chemical synthesis processes. The company’s large-scale production capabilities make it a key volume supplier to the global market.

Key Strengths and Initiatives:

• Significant production capacity, estimated at over 100 tons annually

• Continuous process optimization to reduce manufacturing costs

• Expansion into higher purity grades for pharmaceutical customers

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1️⃣ 1. BOC Sciences

Headquarters: Shirley, New York, USA
Key Offering: High-Purity Protocatechuic Acid, Research Chemicals

BOC Sciences stands as a global leader in the supply of high-purity fine chemicals, including pharmaceutical-grade Protocatechuic Acid. While many top producers are China-based, BOC Sciences represents the growing presence of Western companies in the high-value segment of this market, catering primarily to research institutions and pharmaceutical developers.

Key Strengths and Initiatives:

• Extensive product catalog serving the global research community

• Rigorous quality assurance meeting international pharmacopeia standards

• Strong distribution network ensuring reliable supply to North American and European markets

Get Full Report Here: Protocatechuic Acid (CAS 99-50-3) Market – View in Detailed Research Report

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🧪 Outlook: The Future of Protocatechuic Acid is Diversified and Innovative

The Protocatechuic Acid market is undergoing a significant transformation. While traditional applications in basic chemical intermediates continue, the industry is witnessing increased investment in high-purity formulations, advanced extraction technologies, and novel biomedical applications.

📈 Key Trends Shaping the Market:

• R&D expansion into PCA’s neuroprotective and anticancer properties

• Growing consumer demand for natural antioxidants in functional foods and supplements

• Technological advancements in extraction and purification methods

• Strategic partnerships between extract suppliers and end-user industries

Get Full Report Here: Protocatechuic Acid (CAS 99-50-3) Market – View in Detailed Research Report

The companies listed above are not only supplying a crucial bioactive compound—they’re driving the innovation and accessibility of natural health solutions for global markets.