The Global Hyaluronic Acid-based Biomaterials Market was valued at USD 204 Million in 2024 and is projected to reach USD 254 Million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 3.2% during the forecast period (2025–2032). This growth is primarily driven by the rising demand for minimally invasive cosmetic procedures, expanding applications in osteoarthritis treatment, and significant technological advancements in bioprocessing and formulation.

As the medical aesthetics and pharmaceutical industries continue to prioritize biocompatible and effective solutions, hyaluronic acid (HA) has emerged as a cornerstone biomaterial. In this blog, we profile the Top 10 Companies in the Hyaluronic Acid-based Biomaterials Industry—a dynamic mix of established biotechnology giants, innovative specialty manufacturers, and vertically integrated producers shaping the future of regenerative medicine and cosmetic enhancement.

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🔟 1. Bloomage BioTechnology

Headquarters: Jinan, Shandong, China
Key Offering: Pharmaceutical-grade HA, Dermal Fillers, Medical-grade HA Raw Materials

Bloomage BioTechnology is the undisputed global leader in hyaluronic acid production, commanding a dominant 42% share of the worldwide market. The company operates a fully integrated supply chain, from microbial fermentation to the production of finished medical and cosmetic products. Its extensive portfolio serves major global pharmaceutical and aesthetics companies, making it a critical supplier for the entire industry.

Innovation Initiatives:

• Pioneering high-purity, high-molecular-weight HA for advanced medical applications

• Significant R&D investment in cross-linked HA technologies for longer-lasting dermal fillers

• Expansion of production capacity to meet growing global demand

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9️⃣ 2. Kewpie Corporation

Headquarters: Tokyo, Japan
Key Offering: Food-grade HA, Cosmetic-grade HA, HA-based Skincare Ingredients

Kewpie Corporation is a Japanese multinational with a long history in hyaluronic acid, originally leveraging its expertise in food science. The company is a key supplier of high-quality HA for nutraceuticals, functional foods, and cosmetic formulations, with a strong focus on purity and safety standards that appeal to international markets.

Innovation Initiatives:

• Development of low-molecular-weight HA for enhanced skin absorption in cosmeceuticals

• Strategic acquisitions to strengthen distribution networks in Europe and North America

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8️⃣ 3. CPN (China Peptides Company)

Headquarters: Hangzhou, Zhejiang, China
Key Offering: HA Active Pharmaceutical Ingredients (APIs), Cosmetic Raw Materials

CPN is a leading Chinese manufacturer specializing in high-purity hyaluronic acid and other bioactive compounds. The company has established itself as a reliable supplier to both domestic and international markets, with a strong emphasis on pharmaceutical-grade applications and compliance with stringent international regulatory standards.

Innovation Initiatives:

• Focus on cGMP-compliant manufacturing processes for pharmaceutical applications

• Investment in scalable fermentation technologies to improve yield and reduce costs

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7️⃣ 4. Shiseido Company

Headquarters: Tokyo, Japan
Key Offering: Premium HA-based Skincare, Proprietary Dermal Fillers, Cosmetic Formulations

Shiseido, a global cosmetics giant, leverages its deep understanding of skin biology to develop advanced hyaluronic acid-based products. While known for its consumer skincare lines, the company also invests significantly in professional aesthetic medical devices, creating a unique bridge between cosmetic and therapeutic HA applications.

Innovation Initiatives:

• Research into HA synergies with other anti-aging compounds like collagen and ceramides

• Development of temperature-sensitive HA gels for controlled-release formulations

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Hyaluronic Acid-based Biomaterials Market – View in Detailed Research Report

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6️⃣ 5. Novozymes A/S

Headquarters: Bagsværd, Denmark
Key Offering: Enzymatic HA Production Technology, Bio-processing Solutions

Novozymes brings a unique biotechnology perspective to the HA market, focusing on innovative enzymatic production methods rather than traditional fermentation. The company’s expertise in industrial enzymes allows for more sustainable and controlled HA synthesis, appealing to manufacturers seeking environmentally friendly production alternatives.

Innovation Initiatives:

• Pioneering enzymatic pathways for HA synthesis with reduced environmental impact

• Collaborations with pharmaceutical companies to develop novel HA-based drug delivery systems

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5️⃣ 6. Shandong Galaxy Bio-Tech

Headquarters: Linyi, Shandong, China
Key Offering: Broad-spectrum HA Grades, OEM/ODM Services, Hyaluronic Acid Sodium Salt

Shandong Galaxy Bio-Tech is a major Chinese producer with significant manufacturing capacity across multiple HA grades. The company serves a diverse client base, from cosmetic brands to pharmaceutical companies, offering customized solutions and competitive pricing that have made it a key player in the global supply chain.

Innovation Initiatives:

• Expansion into value-added HA derivatives for specialized medical applications

• Investment in purification technologies to achieve higher grades suitable for injectable products

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4️⃣ 7. China Eastar

Headquarters: Xi’an, Shaanxi, China
Key Offering: Pharmaceutical Intermediates, Cosmetic-grade HA, HA for Ophthalmology

China Eastar has carved out a significant niche in the hyaluronic acid market, particularly in pharmaceutical intermediates and specialty grades. The company’s focus on stringent quality control and regulatory compliance has enabled it to become a trusted supplier for sensitive medical applications, including ophthalmic surgery aids.

Innovation Initiatives:

• Specialization in ultra-pure HA for ophthalmic viscoelastic devices (OVDs)

• Development of sterile HA formulations for advanced wound care applications

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3️⃣ 8. FocusChem Biotech

Headquarters: Shanghai, China
Key Offering: Custom HA Synthesis, Modified HA Polymers, Research-grade HA

FocusChem Biotech distinguishes itself through specialization in custom hyaluronic acid solutions and chemically modified HA polymers. The company works closely with research institutions and innovative pharmaceutical companies to develop novel HA-based materials with specific functional properties for advanced therapeutic applications.

Innovation Initiatives:

• Expertise in HA functionalization for targeted drug delivery and tissue engineering

• Collaborative R&D projects with academic institutions on next-generation biomaterials

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2️⃣ 9. Givaudan Active Beauty

Headquarters: Vernier, Switzerland
Key Offering: HA-based Active Cosmetic Ingredients, Skincare Actives, Preservative Systems

Givaudan Active Beauty, part of the global fragrance and flavor leader, applies its extensive material science expertise to hyaluronic acid. The company focuses on developing innovative HA derivatives and delivery systems that enhance the efficacy and stability of HA in cosmetic formulations, serving premium beauty brands worldwide.

Innovation Initiatives:

• Development of encapsulated HA for improved skin penetration and lasting hydration

• Creation of HA complexes with botanical extracts for multifunctional skincare benefits

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1️⃣ 10. Contipro

Headquarters: Dolní Dobrouč, Czech Republic
Key Offering: High-purity HA, Medical-grade HA, HA for Regenerative Medicine

Contipro stands out as a European leader in high-quality hyaluronic acid production, with a strong focus on pharmaceutical and medical device applications. The company’s commitment to innovation and quality has positioned it as a key supplier for the European medical market, particularly in advanced wound care and tissue engineering.

Innovation Initiatives:

• Proprietary fermentation technology for consistent high-molecular-weight HA production

• Significant investment in HA research for advanced regenerative medicine applications

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Hyaluronic Acid-based Biomaterials Market – View in Detailed Research Report

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🌍 Outlook: The Future of Hyaluronic Acid Biomaterials Is Diverse and Innovative

The hyaluronic acid-based biomaterials market is undergoing a significant transformation. While traditional dermal fillers and osteoarthritis treatments continue to drive volume, the industry is rapidly expanding into novel therapeutic areas and developing next-generation formulations with enhanced properties and functionality.

📈 Key Trends Shaping the Market:

• R&D expansion into combination products integrating HA with growth factors and stem cells

• Increasing regulatory harmonization facilitating global market access for innovative HA products

• Advancements in production biotechnology reducing costs and improving sustainability

• Growing pharmaceutical industry adoption of HA for advanced drug delivery systems

Get Full Report Here:
Hyaluronic Acid-based Biomaterials Market – View in Detailed Research Report

The companies profiled above are not only supplying essential biomaterials—they’re driving the innovation trajectory of medical aesthetics, regenerative medicine, and advanced therapeutics worldwide.