The Global Hyaluronic Acid-based Biomaterials Market was valued at USD 204 Million in 2024 and is projected to reach USD 254 Million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 3.2% during the forecast period (2024–2032). This growth is being driven by the escalating demand for minimally invasive cosmetic procedures, the expanding therapeutic applications in osteoarthritis treatment, and the accelerating innovation in advanced biomaterial formulations across the medical and aesthetics sectors.

As the healthcare and personal care industries increasingly adopt biocompatible and versatile solutions, the spotlight is on the key manufacturers who are driving research, production, and commercialization of high-quality hyaluronic acid. In this blog, we profile the Top 10 Companies in the Hyaluronic Acid-based Biomaterials Industry—a mix of biotechnology pioneers, established chemical giants, and specialty manufacturers shaping the future of regenerative medicine and aesthetics.

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🔟 1. Bloomage BioTechnology

Headquarters: Jinan, Shandong, China
Key Offering: Pharmaceutical Grade HA, Cosmetic Grade HA, Dermal Fillers

Bloomage BioTechnology is the undisputed global leader in hyaluronic acid production, holding a commanding 42% share of global manufacturing capacity. The company operates a fully integrated supply chain, from microbial fermentation to finished medical-grade products. Its extensive portfolio serves major pharmaceutical companies and aesthetic device manufacturers worldwide, with a strong focus on high-purity, high-molecular-weight HA for advanced applications.

Innovation Initiatives:

• Pioneering research in cross-linked HA for longer-lasting dermal fillers
• Strategic partnerships with global cosmetic and pharmaceutical giants
• Investing in sustainable fermentation technologies to reduce production costs

Download FREE Sample Report: Hyaluronic Acid-based Biomaterials Market – View in Detailed Research Report

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9️⃣ 2. Kewpie Corporation

Headquarters: Tokyo, Japan
Key Offering: Food Grade HA, Cosmetic Grade HA, Pharmaceutical Intermediates

Kewpie Corporation, a Japanese food and ingredient conglomerate, is a major producer of hyaluronic acid derived from its proprietary bacterial fermentation process. The company leverages its expertise in bio-fermentation to produce highly pure HA for nutritional supplements, skincare products, and pharmaceutical applications, with a strong presence across Asian and North American markets.

Innovation Initiatives:

• Development of low-molecular-weight HA for enhanced skin absorption
• Expansion into functional foods and nutraceuticals containing HA
• Focus on environmentally friendly production methods

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8️⃣ 3. Shandong Galaxy Bio-Tech

Headquarters: Linyi, Shandong, China
Key Offering: Cosmetic Grade HA, Pharmaceutical Grade HA, Oligo-HA

Shandong Galaxy Bio-Tech is one of China’s leading HA producers, specializing in both standard and customized hyaluronic acid formulations. The company has significantly expanded its production capacity in recent years to meet growing global demand, particularly for cost-effective cosmetic-grade materials used in serums, creams, and masks.

Innovation Initiatives:

• Advanced purification technologies for pharmaceutical-grade HA
• Custom molecular weight HA production for specific application needs
• Strong export-oriented business model targeting international markets

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7️⃣ 4. CPN

Headquarters: Shandong, China
Key Offering: Industrial Grade HA, Cosmetic Grade HA, HA Raw Materials

CPN (China Peptides Company) is a significant player in the hyaluronic acid supply chain, providing raw materials to cosmetic and pharmaceutical formulators. The company focuses on scalable production to serve the high-volume needs of the global personal care industry, with competitive pricing and consistent quality.

Innovation Initiatives:

• Cost-optimized production processes for competitive pricing
• Supply chain integration to ensure raw material stability
• Quality control systems meeting international standards

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6️⃣ 5. Shiseido Company

Headquarters: Tokyo, Japan
Key Offering: Premium HA-based Skincare, Dermal Fillers, Advanced Formulations

While primarily a cosmetic giant, Shiseido has developed substantial expertise in hyaluronic acid applications through its extensive R&D in skincare and aesthetic medicine. The company utilizes HA in its high-end skincare lines and has ventured into medical aesthetics with advanced HA-based dermal fillers that combine anti-aging benefits with skin health improvement.

Innovation Initiatives:

• Proprietary HA stabilization technologies
• Combination products integrating HA with other active ingredients
• Clinical research on HA’s long-term skin benefits

Download FREE Sample Report: Hyaluronic Acid-based Biomaterials Market – View in Detailed Research Report

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5️⃣ 6. Novozymes A/S

Headquarters: Bagsværd, Denmark
Key Offering: Enzymatic HA Production, Sustainable HA Solutions, Custom Bioprocessing

Novozymes brings its world-leading expertise in industrial enzymes to the hyaluronic acid market through innovative enzymatic production methods. The company’s approach offers a more sustainable and controllable alternative to traditional fermentation, producing HA with specific molecular characteristics for specialized medical and cosmetic applications.

Innovation Initiatives:

• Enzymatic synthesis for precise molecular weight control
• Sustainable production methods with reduced environmental impact
• Partnerships with pharmaceutical companies for novel HA applications

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4️⃣ 7. China Eastar

Headquarters: Shandong, China
Key Offering: Standard Grade HA, Custom HA Formulations, Bulk HA Supply

China Eastar has established itself as a reliable supplier of hyaluronic acid to both domestic and international markets. The company focuses on maintaining consistent quality across its product range while offering competitive pricing, making it a preferred supplier for many cosmetic manufacturers seeking cost-effective HA ingredients.

Innovation Initiatives:

• Continuous improvement of fermentation yield and efficiency
• Expansion into higher-value pharmaceutical-grade segments
• Development of HA derivatives with enhanced functional properties

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3️⃣ 8. FocusChem Biotech

Headquarters: Shandong, China
Key Offering: HA for Cosmetics, HA for Nutraceuticals, Technical Grade HA

FocusChem Biotech specializes in hyaluronic acid production with a particular focus on the cosmetic and nutraceutical industries. The company has developed expertise in producing HA with specific properties tailored for formulation compatibility and functional performance in final products.

Innovation Initiatives:

• Application-specific HA product development
• Technical support for formulators using HA ingredients
• Quality systems ensuring batch-to-batch consistency

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2️⃣ 9. Givaudan

Headquarters: Geneva, Switzerland
Key Offering: Premium HA Ingredients, HA-based Active Cosmetics, Custom Solutions

Givaudan, a global leader in fragrances and flavors, has expanded into active cosmetic ingredients including hyaluronic acid through strategic acquisitions and internal development. The company offers high-performance HA ingredients to the prestige skincare market, often combined with other actives for enhanced efficacy.

Innovation Initiatives:

• Development of multi-functional HA complexes
• Sustainable sourcing and production practices
• Clinical validation of HA efficacy in cosmetic formulations

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1️⃣ 10. Contipro

Headquarters: Dolní Dobrouč, Czech Republic
Key Offering: High-Purity Medical HA, Modified HA Derivatives, Specialty HA Products

Contipro stands out as a European specialty manufacturer focusing on high-value, innovative hyaluronic acid products for medical and advanced cosmetic applications. The company invests heavily in R&D to develop patented HA derivatives with unique properties for targeted therapeutic and aesthetic uses.

Innovation Initiatives:

• Patented HA modification technologies
• Focus on medical-grade HA for regenerative medicine
• Collaborative research with academic institutions

Get Full Report Here: Hyaluronic Acid-based Biomaterials Market – View in Detailed Research Report

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🔬 Outlook: The Future of Hyaluronic Acid-based Biomaterials Is Smarter and More Specialized

The hyaluronic acid-based biomaterials market is undergoing a significant transformation. While traditional applications in dermal fillers and osteoarthritis treatments continue to dominate, the industry is investing heavily in advanced formulations, combination therapies, and innovative production technologies.

📈 Key Trends Shaping the Market:

• R&D focus on long-lasting, cross-linked HA formulations for extended therapeutic effects
• Growing adoption of HA in regenerative medicine and advanced wound care applications
• Increasing demand for sustainable and animal-free HA production methods
• Expansion into emerging markets with growing medical aesthetics sectors

Get Full Report Here: Hyaluronic Acid-based Biomaterials Market – View in Detailed Research Report

The companies listed above are not only supplying critical biomaterials—they’re driving the innovation engine that will define the next generation of medical and aesthetic treatments.