The Global Hydroxyapatite Market was valued at USD 136 Million in 2024 and is projected to reach USD 220 Million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 7.4% during the forecast period (2025–2032). This robust growth is fueled by the rising prevalence of orthopedic and dental disorders, an aging global population, and significant advancements in bioactive material technologies for medical applications.

As the healthcare industry pivots toward regenerative medicine and bioactive solutions, the spotlight intensifies on the key manufacturers pioneering the development and commercialization of hydroxyapatite. In this blog, we profile the Top 10 Companies in the Hydroxyapatite Industry—a dynamic mix of established medical device giants, specialized biomaterial innovators, and research-focused entities shaping the future of bone regeneration and tissue engineering.

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🔟 1. Berkeley Advanced Biomaterials Inc.

Headquarters: Berkeley, California, USA
Key Offering: Medical-grade Hydroxyapatite, Nano-Hydroxyapatite, Custom Ceramic Powders

Berkeley Advanced Biomaterials is a leading supplier of high-purity hydroxyapatite for biomedical research and clinical applications. The company specializes in producing synthetic hydroxyapatite with controlled stoichiometry, crystallinity, and particle size, catering to the stringent requirements of the medical device and pharmaceutical industries.

Innovation Initiatives:

• Development of proprietary nano-Hydroxyapatite for enhanced bioactivity

• Strategic partnerships with academic institutions for material science research

• Expansion of GMP-compliant manufacturing capabilities for implantable grades

Download FREE Sample Report: Hydroxyapatite Market – View in Detailed Research Report

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9️⃣ 2. Fluidinova S.A.

Headquarters: Maia, Portugal
Key Offering: NanoXIM® Hydroxyapatite, Customized Nanoparticles, Colloidal Dispersions

Fluidinova is a prominent manufacturer of nanoscale hydroxyapatite, recognized for its NanoXIM® product line. The company’s expertise lies in producing highly stable colloidal dispersions and powders used in dental care, bone cements, and advanced drug delivery systems, serving clients across Europe, North America, and Asia.

Innovation Initiatives:

• FDA-cleared bone graft substitute products

• Focus on sustainable and scalable nanoparticle synthesis

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8️⃣ 3. SigmaGraft Biomaterials

Headquarters: San Diego, California, USA
Key Offering: Synthetic Bone Graft Substitutes, Porous Hydroxyapatite Granules

SigmaGraft specializes in synthetic bone graft materials, offering a range of porous hydroxyapatite products designed to mimic the structure of natural bone. Their solutions are widely used in spinal fusion, dental bone augmentation, and orthopedic trauma surgeries.

Innovation Initiatives:

• Proprietary manufacturing process for optimal pore interconnectivity

• Clinical studies demonstrating high fusion rates in spinal applications

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7️⃣ 4. CAM Bioceramics B.V.

Headquarters: Leiden, Netherlands
Key Offering: BONEspan® Hydroxyapatite, Custom-shaped Ceramic Implants

CAM Bioceramics is a European leader in developing and manufacturing medical-grade hydroxyapatite ceramics. The company’s BONEspan® products are used in cranio-maxillofacial surgery, providing surgeons with patient-specific solutions for complex reconstructions.

Innovation Initiatives:

• Advanced 3D printing capabilities for patient-specific implants

• Strong focus on regulatory compliance (CE Mark, FDA approvals)

Download FREE Sample Report: Hydroxyapatite Market – View in Detailed Research Report

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6️⃣ 5. Zimmer Biomet Holdings, Inc.

Headquarters: Warsaw, Indiana, USA
Key Offering: Hydroxyapatite-coated Orthopedic Implants, Bone Graft Substitutes

Zimmer Biomet is a global leader in musculoskeletal healthcare, integrating hydroxyapatite coatings onto its extensive portfolio of joint replacement and trauma devices. The company’s proprietary coating technologies enhance implant fixation and long-term stability through improved osseointegration.

Innovation Initiatives:

• Research in nano-crystalline hydroxyapatite coatings

• Development of combination products with growth factors

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5️⃣ 6. Bonesupport AB

Headquarters: Lund, Sweden
Key Offering: CERAMENT® |G, CERAMENT® |V, Injectable Bone Graft Substitutes

Bonesupport AB is a Scandinavian company specializing in injectable hydroxyapatite-based bone graft substitutes. Their CERAMENT® platform combines osteoconductive hydroxyapatite with the option for antibiotic elution, addressing both bone void filling and infection management in orthopedic surgery.

Innovation Initiatives:

• Pioneering antibiotic-eluting bone graft technology

• Global expansion of commercial footprint in key markets

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4️⃣ 7. Granulab (M) Sdn Bhd

Headquarters: Kelantan, Malaysia
Key Offering: Natural Hydroxyapatite from Bovine Source, BONITmatrix®

Granulab is a key player in the Asia-Pacific region, producing natural hydroxyapatite derived from bovine bone. Their BONITmatrix® products offer a cost-effective alternative to synthetic options while maintaining excellent biocompatibility and osteoconductive properties.

Innovation Initiatives:

• Sustainable sourcing and processing of natural raw materials

• Expansion into emerging markets with affordable solutions

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3️⃣ 8. Bio-Rad Laboratories, Inc.

Headquarters: Hercules, California, USA
Key Offering: Research-grade Hydroxyapatite, Chromatography Media, Biochemicals

While primarily known for life science research tools, Bio-Rad is a significant supplier of hydroxyapatite for protein purification and biochemical research. Their ceramic hydroxyapatite serves as a crucial chromatography medium in biopharmaceutical manufacturing and academic research.

Innovation Initiatives:

• Development of high-capacity chromatography media

• Support for biopharmaceutical process development

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2️⃣ 9. Sigma-Aldrich (Merck KGaA)

Headquarters: Darmstadt, Germany
Key Offering: Laboratory-grade Hydroxyapatite, Analytical Standards, Research Chemicals

As part of the Merck Group, Sigma-Aldrich supplies high-purity hydroxyapatite to the global research community. The company provides materials for fundamental studies in biomaterials science, tissue engineering, and drug delivery research.

Innovation Initiatives:

• Support for academic and industrial R&D programs

• Quality assurance for research reproducibility

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1️⃣ 10. Plasma Biotal Limited

Headquarters: Tideswell, United Kingdom
Key Offering: Medical-grade Hydroxyapatite Powders, Custom Ceramic Manufacturing

Plasma Biotal is a specialized manufacturer of high-purity hydroxyapatite for medical and dental applications. The company offers both standard and custom-formulated products, serving medical device companies seeking reliable ceramic components for their implant systems.

Innovation Initiatives:

• Tailored material properties for specific clinical applications

• Collaborations with medical device OEMs on product development

Get Full Report Here: Hydroxyapatite Market – View in Detailed Research Report

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🔬 Outlook: The Future of Hydroxyapatite Is Personalized and Multifunctional

The hydroxyapatite market is undergoing a significant transformation. While traditional bone graft applications continue to dominate, the industry is investing heavily in advanced material science, additive manufacturing, and multifunctional composites that extend beyond structural support.

📈 Key Trends Shaping the Market:

• Rapid adoption of 3D printing for patient-specific implants

• Development of drug-eluting hydroxyapatite for combined therapy

• Increasing regulatory acceptance of synthetic over natural sources

• Expansion into emerging applications in cosmetics and dermatology

Get Full Report Here: Hydroxyapatite Market – View in Detailed Research Report

The companies profiled above are not only supplying critical biomaterials—they’re driving the next generation of regenerative medicine solutions that improve patient outcomes worldwide.