The Global Natto Extract Market was valued at USD 1.2 Billion in 2023 and is projected to reach USD 1.9 Billion by 2030, growing at a Compound Annual Growth Rate (CAGR) of 6.8% during the forecast period (2024–2030). This robust growth is primarily fueled by increasing consumer awareness of natural health supplements, rising demand for plant-based functional ingredients, and extensive scientific validation of the benefits of nattokinase, the key enzyme in natto extract, for cardiovascular and circulatory health.

As the global wellness industry pivots towards evidence-based, naturally derived active compounds, the spotlight intensifies on the key manufacturers and suppliers driving innovation, quality, and accessibility in the natto extract space. In this blog, we profile the Top 10 Companies in the Natto Extract Industry—a diverse mix of established nutraceutical giants, specialized biotechnology firms, and emerging market leaders shaping the future of this vital health ingredient.

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🔟 1. Japan Bio Science Laboratory Co., Ltd. (JBSL)

Headquarters: Osaka, Japan
Key Offering: Nattokinase NSK-SD® (Highly Purified), Standardized Natto Extract Powders

Japan Bio Science Laboratory is a pioneer and one of the most respected names in the nattokinase sector. The company’s flagship ingredient, NSK-SD®, is a highly purified form of nattokinase that has been the subject of numerous clinical studies, establishing its efficacy and safety profile. JBSL supplies its ingredients to dietary supplement manufacturers worldwide.

Key Initiatives & Strengths:

• Holder of key patents for nattokinase purification and stabilization processes.
• Extensive portfolio of clinical research supporting product claims.
• Strong focus on B2B partnerships with global supplement brands.

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9️⃣ 2. Daiwa Pharmaceutical Co., Ltd.

Headquarters: Tokyo, Japan
Key Offering: Daiwa Nattokinase (capsules and powder), Private Label manufacturing

Daiwa Pharmaceutical is a leading Japanese company dedicated to the research, development, and manufacturing of nattokinase supplements. With a history steeped in fermentation technology, Daiwa controls its production from non-GMO soybeans to the final encapsuled product, ensuring stringent quality control.

Key Initiatives & Strengths:

• Vertically integrated manufacturing process from raw material sourcing to finished goods.
• Strong presence in the Japanese domestic market and expanding international footprint.
• Offers comprehensive private-label and contract manufacturing services.

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8️⃣ 3. NOW Foods

Headquarters: Bloomingdale, Illinois, USA
Key Offering: NOW Supplements Nattokinase (various potencies), Consumer-facing brands

NOW Foods is a major American distributor and manufacturer of natural products, including a popular line of nattokinase supplements. While it sources its nattokinase, the company’s strength lies in its massive distribution network, brand recognition, and commitment to quality testing, making natto extract accessible to a vast consumer base in North America and beyond.

Key Initiatives & Strengths:

• Extensive retail and online distribution channels.
• Rigorous in-house quality assurance and testing (GMP certified facilities).
• Strong consumer trust and brand loyalty in the health food sector.

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Natto Extract Market – View in Detailed Research Report

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7️⃣ 4. Doctor’s Best Inc.

Headquarters: Irvine, California, USA
Key Offering: Doctor’s Best Nattokinase, Science-based formulations

Doctor’s Best is a leading science-based dietary supplement brand known for partnering with ingredient innovators. Their nattokinase product often features validated, branded ingredients like JBSL’s NSK-SD®, which appeals to health-conscious consumers seeking proven efficacy. The company focuses on delivering high-quality, research-backed nutritional supplements.

Key Initiatives & Strengths:

• Strategic partnerships with premier ingredient suppliers.
• Emphasis on scientific validation and transparent labeling.
• Strong presence in specialty retail and e-commerce platforms.

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6️⃣ 5. Jarrow Formulas

Headquarters: Los Angeles, California, USA
Key Offering: Jarrow Formulas Nattokinase, Full-spectrum health supplements

Jarrow Formulas is a well-established brand in the natural products industry, offering a comprehensive range of dietary supplements, including a potent nattokinase formula. The company is recognized for its optimal bio-availability formulations, quality control, and educational approach to consumer health.

Key Initiatives & Strengths:

• Reputation for high-quality, innovative formulations.
• Global distribution network spanning over 40 countries.
• Commitment to purity, potency, and product integrity.

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5️⃣ 6. Schwabe Group (Europe)

Headquarters: Karlsruhe, Germany
Key Offering: Natto extract ingredients for pharmaceutical and nutraceutical use

The Schwabe Group is a global leader in plant-based medicines and natural health products. Through its subsidiaries and extensive R&D capabilities, Schwabe is a significant player in the European market for standardized botanical extracts, including nattokinase, which is used in cardiovascular health supplements.

Key Initiatives & Strengths:

• Over 150 years of experience in phytopharmaceuticals.
• Strong regulatory expertise for markets in Europe and internationally.
• Vertically integrated from raw material to finished product development.

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4️⃣ 7. Source Naturals

Headquarters: Scotts Valley, California, USA
Key Offering: Source Naturals Nattokinase, Wellness Formula® blends

Source Naturals is a prominent dietary supplement company known for its innovative Wellness Formulas® and single-ingredient supplements. The company offers nattokinase as a standalone product, emphasizing its role in supporting healthy circulation, thereby catering to a dedicated consumer segment seeking targeted health solutions.

Key Initiatives & Strengths:

• Innovative product development combining multiple synergistic ingredients.
• Long-standing reputation and trust within the natural products community.
• Focus on accessibility and consumer education.

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3️⃣ 8. Healthy Origins

Headquarters: Pittsburgh, Pennsylvania, USA
Key Offering: Healthy Origins Nattokinase, High-value supplements

Healthy Origins specializes in providing high-potency, purity-guaranteed nutritional supplements at a competitive value. Their nattokinase product is a key offering in their cardiovascular support category, appealing to cost-conscious consumers who do not want to compromise on quality.

Key Initiatives & Strengths:

• Commitment to providing high-quality supplements at excellent value.
• Strong manufacturing partnerships and supply chain management.
• Significant market share in the value segment of the supplement industry.

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2️⃣ 9. Pure Encapsulations

Headquarters: Sudbury, Massachusetts, USA
Key Offering: Pure Encapsulations Nattokinase, Hypoallergenic professional-grade supplements

Pure Encapsulations is a leading manufacturer of hypoallergenic, research-based dietary supplements often recommended by healthcare practitioners. Their nattokinase product is designed to meet the high standards of purity and potency required by the professional channel, free from unnecessary excipients and allergens.

Key Initiatives & Strengths:

• Strong focus on the healthcare practitioner distribution channel.
• Rigorous quality control and hypoallergenic standards.
• Products are backed by scientific research and formulated for optimal absorption.

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1️⃣ 10. Solgar Inc.

Headquarters: Leonia, New Jersey, USA
Key Offering: Solgar Nattokinase, Premium “Gold Standard” vitamins and supplements

Solgar is a globally recognized premium brand with a history spanning over 70 years. The company’s nattokinase supplement is part of its comprehensive range of products that adhere to its “Gold Standard” of quality, innovation, and integrity, targeting discerning consumers who prioritize brand heritage and quality assurance.

Key Initiatives & Strengths:

• Global brand recognition and a long-standing reputation for quality.
• Wide availability in health food stores, pharmacies, and online retailers worldwide.
• Commitment to using high-quality raw materials and advanced manufacturing techniques.

Get Full Report Here:
Natto Extract Market – View in Detailed Research Report

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🌱 Outlook: The Future of Natto Extract is Rooted in Science and Sustainability

The natto extract market is experiencing a significant transformation. While traditional supplements continue to dominate sales, the industry is increasingly focused on clinical validation, advanced delivery systems, and sustainable sourcing to meet the demands of a more knowledgeable and health-conscious global consumer base.

📈 Key Trends Shaping the Market:

• Growing consumer preference for natural and plant-based solutions for cardiovascular wellness.
• Increased investment in clinical research to expand approved health claims for nattokinase.
• Rising demand for combination formulas that pair nattokinase with other heart-health nutrients like CoQ10 and aged garlic extract.
• Expansion into new geographic markets, particularly in Europe and North America, driven by aging populations.

Get Full Report Here:
Natto Extract Market – View in Detailed Research Report

The companies listed above are not only supplying a powerful enzyme—they are advancing the science of natural cardiovascular support and making a proven traditional remedy accessible on a global scale.