The Global Nutlin-3 Market was valued at USD 45.2 Million in 2023 and is projected to reach USD 78.9 Million by 2030, growing at a Compound Annual Growth Rate (CAGR) of 8.3% during the forecast period (2023–2030). This robust growth is fueled by the increasing prevalence of cancer, rising investments in oncology research, and the expanding understanding of the p53 tumor suppressor pathway as a critical therapeutic target.

As the field of targeted cancer therapy advances, the focus intensifies on the key biochemical suppliers and research companies providing high-purity Nutlin-3 compounds. These molecules, which disrupt the MDM2-p53 protein interaction, are essential tools for both academic research and drug discovery pipelines. In this blog, we profile the Top 10 Companies in the Nutlin-3 Market—a mix of established chemical suppliers and specialized life science innovators shaping the future of cancer research.

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🔟 1. Cayman Chemical Company

Headquarters: Ann Arbor, Michigan, USA
Key Offering: Nutlin-3, Nutlin-3a (active enantiomer), Nutlin-3b (inactive enantiomer)

Cayman Chemical is a leading global supplier of biochemicals for research, offering high-purity, well-characterized Nutlin-3 compounds. The company provides comprehensive analytical data, including HPLC and MS reports, ensuring reliability for critical cancer research applications. Their products are widely used in academic institutions, pharmaceutical companies, and biotechnology firms for studying apoptosis and cell cycle regulation.

Research Support Initiatives:

• Extensive product validation with biological activity data
• Global distribution network with cold chain logistics
• Technical support from PhD-level scientists

Download FREE Sample Report: Nutlin-3 Market – View in Detailed Research Report

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9️⃣ 2. Selleck Chemicals

Headquarters: Houston, Texas, USA
Key Offering: Nutlin-3, Nutlin-3a, Nutlin-3b, and related p53-MDM2 pathway inhibitors

Selleck Chemicals is renowned for its vast portfolio of high-quality inhibitors, including the Nutlin series. The company emphasizes strict quality control, with each batch undergoing rigorous testing for purity and biological activity. Their products are instrumental in preclinical studies for cancer drug development worldwide.

Research Support Initiatives:

• Large-scale synthesis capabilities for bulk orders
• Regularly updated product citations from scientific literature
• Custom synthesis services for analog development

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8️⃣ 3. MedChemExpress (MCE)

Headquarters: Monmouth Junction, New Jersey, USA
Key Offering: Nutlin-3, Nutlin-3a, Nutlin-3b, and novel MDM2 antagonists

MedChemExpress (MCE) provides a wide range of bioactive small molecules for research. Their Nutlin-3 offerings are backed by comprehensive biological data and are used extensively in screening assays and mechanistic studies focused on reactivating p53 in cancer cells.

Research Support Initiatives:

• Competitive pricing for academic and industrial researchers
• Fast worldwide shipping with reliable cold chain management
• Active involvement in collaborative research projects

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7️⃣ 4. Sigma-Aldrich (Merck KGaA)

Headquarters: Darmstadt, Germany
Key Offering: Nutlin-3, analytical standards, and custom formulation services

As part of the global Merck KGaA group, Sigma-Aldrich offers Nutlin-3 under its high-purity brand, certified for research use. The company’s extensive infrastructure ensures consistent supply and quality, catering to large pharmaceutical clients and research consortia.

Research Support Initiatives:

• ISO-certified manufacturing facilities
• Integration with Merck’s broader life science portfolio
• Support for regulatory and compliance requirements

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6️⃣ 5. Toronto Research Chemicals (TRC)

Headquarters: Toronto, Ontario, Canada
Key Offering: Nutlin-3 and its metabolites, stable isotope-labeled Nutlin-3 for ADME studies

Toronto Research Chemicals specializes in the synthesis of complex organic molecules for research. TRC is a key supplier of Nutlin-3 and related compounds, particularly for pharmacokinetic and metabolic studies crucial for drug development.

Research Support Initiatives:

• Expertise in synthesizing deuterated and other labeled compounds
• Strong focus on product authenticity and traceability
• Collaborations with academic research groups

Download FREE Sample Report: Nutlin-3 Market – View in Detailed Research Report

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5️⃣ 6. APExBIO Technology LLC

Headquarters: Houston, Texas, USA
Key Offering: Nutlin-3, optimized formulations for in vivo studies, screening libraries

APExBIO provides high-quality research chemicals with a focus on bioavailability and application-specific formulations. Their Nutlin-3 products are designed for both in vitro and in vivo studies, supporting the transition from bench to bedside in oncology research.

Research Support Initiatives:

• Development of soluble formulations for animal studies
• Large-scale production for high-throughput screening
• Application notes and detailed protocols for users

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4️⃣ 7. BioVision, Inc.

Headquarters: Milpitas, California, USA
Key Offering: Nutlin-3, apoptosis assay kits, and pathway-focused research bundles

BioVision offers Nutlin-3 as part of its comprehensive portfolio of research tools for cell biology and biochemistry. The company often bundles its compounds with relevant assay kits, providing a complete solution for researchers studying the p53 pathway.

Research Support Initiatives:

• Integrated product offerings with related research tools
• Focus on user-friendly protocols and application support
• Strong presence in the academic research market

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3️⃣ 8. Target Molecule Corp.

Headquarters: Boston, Massachusetts, USA
Key Offering: Nutlin-3, proprietary MDM2 inhibitors, and fragment-based screening compounds

Target Molecule Corp. specializes in inhibitors for drug discovery, with Nutlin-3 being a key product in their oncology portfolio. The company works closely with pharmaceutical partners to supply compounds for lead optimization programs.

Research Support Initiatives:

• Focus on structure-activity relationship (SAR) support
• Supply of analogs for medicinal chemistry programs
• Confidential custom synthesis for client-specific projects

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2️⃣ 9. StressMarq Biosciences Inc.

Headquarters: Victoria, British Columbia, Canada
Key Offering: Nutlin-3, antibodies for p53 pathway proteins, and related biochemicals

StressMarq Biosciences provides a unique combination of small molecules and biological reagents. Their offering of Nutlin-3 is complemented by antibodies and assays for detecting p53 activation, providing a synergistic toolkit for researchers.

Research Support Initiatives:

• Integrated platform of small molecules and biologics
• Specialization in stress and apoptosis signaling pathways
• Support for translational research projects

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1️⃣ 10. Ambeed

Headquarters: Arlington Heights, Illinois, USA
Key Offering: Nutlin-3, building blocks for analog synthesis, and process development services

Ambeed is a growing supplier of research chemicals, including Nutlin-3, with a strong emphasis on chemical synthesis expertise. The company serves both the research market and provides intermediates for pharmaceutical development.

Research Support Initiatives:

• Competitive sourcing and synthesis capabilities
• Scalable production from milligram to kilogram scale
• Collaborative approach to custom chemical projects

Get Full Report Here: Nutlin-3 Market – View in Detailed Research Report

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🧬 Outlook: The Future of Nutlin-3 in Oncology and Beyond

The Nutlin-3 market is evolving beyond a research tool to a cornerstone in the development of novel cancer therapeutics. While its primary application remains in academic and pharmaceutical research, the compound’s role in validating the p53-MDM2 axis has paved the way for next-generation clinical candidates.

📈 Key Trends Shaping the Market:

• Increasing use of Nutlin-3 in combination therapy studies with other anticancer agents
• Growing demand for high-purity GMP-grade material for preclinical development
• Expansion into new therapeutic areas beyond oncology, such as neurodegenerative diseases
• Rising investments in small molecule therapeutics that target protein-protein interactions

Get Full Report Here: Nutlin-3 Market – View in Detailed Research Report

The companies profiled above are not only supplying critical research reagents—they are enabling the next wave of innovation in targeted cancer therapy and beyond.