The Global Pharmaceutical Grade Hyaluronic Acid Market was valued at USD 151.60 million in 2023 and is projected to reach USD 278.98 million by 2029, growing at a Compound Annual Growth Rate (CAGR) of 10.70% during the forecast period (2024–2029). This robust growth is being driven by the rising prevalence of osteoarthritis, increasing demand for minimally invasive aesthetic procedures, and the expanding application of hyaluronic acid in advanced ophthalmic surgeries and wound care.

As the healthcare industry increasingly embraces biopolymer-based therapeutics for their superior biocompatibility and efficacy, the focus shifts to the key manufacturers who are pioneering high-purity HA production and novel pharmaceutical applications. In this blog, we profile the Top 10 Companies in the Pharmaceutical Grade Hyaluronic Acid Industry—a blend of biotechnology innovators, established chemical giants, and specialty pharmaceutical suppliers shaping the future of regenerative medicine and drug delivery.

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Global Pharmaceutical Grade Hyaluronic Acid Market – View in Detailed Research Report

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🔟 1. Bloomage Bio Technology

Headquarters: Jinan, Shandong, China
Key Offering: High Purity Sodium Hyaluronate API, HA-based Drug Delivery Systems

Bloomage BioTechnology is a global leader in hyaluronic acid production, boasting one of the largest fermentation capacities worldwide. The company supplies pharmaceutical-grade HA as an active pharmaceutical ingredient (API) for a wide range of applications, from intra-articular injections for osteoarthritis to ophthalmic viscoelastic devices.

Innovation & Development Initiatives:

• Extensive R&D in cross-linked HA technologies for sustained drug release

• Strategic partnerships with global pharmaceutical companies for novel HA-based therapeutics

• Focus on achieving the highest purity levels (>99%) for critical pharmaceutical applications

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9️⃣ 2. LG Group (LG Chem)

Headquarters: Seoul, South Korea
Key Offering: Pharmaceutical Grade HA, Bio-materials for Medical Devices

LG Chem, a division of the LG Group, is a major producer of high-quality hyaluronic acid. Its pharmaceutical-grade HA is utilized in viscosupplementation products, dermal fillers, and as an excipient in various drug formulations, leveraging the company’s strong background in chemical and biological engineering.

Innovation & Development Initiatives:

• Investment in green biotechnology for sustainable HA production

• Development of next-generation HA hydrogels for tissue engineering

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8️⃣ 3. Galderma (Nestlé Skin Health)

Headquarters: Lausanne, Switzerland
Key Offering: RESTYLANE® dermal fillers, Pharmaceutical Formulations containing HA

Galderma, part of the Nestlé ecosystem, is a world-renowned player in dermatology. While famously known for its RESTYLANE® range of dermal fillers, the company also develops and utilizes pharmaceutical-grade hyaluronic acid in its medical skincare and therapeutic products, focusing on purity and clinical performance.

Innovation & Development Initiatives:

• Pioneering NASHA™ (Non-Animal Stabilized Hyaluronic Acid) technology

• Continuous clinical research to expand HA indications in medical dermatology

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7️⃣ 4. HUONS

Headquarters: Seongnam-si, Gyeonggi-do, South Korea
Key Offering: HUTOUCH® intra-articular injections, HA-based Pharmaceuticals

HUONS is a leading South Korean pharmaceutical company with a strong focus on biologics and injectables. Its dedicated biopharmaceutical division produces high-purity hyaluronic acid for its own branded viscosupplements and supplies HA APIs to other pharmaceutical manufacturers.

Innovation & Development Initiatives:

• Development of long-lasting, high molecular weight HA formulations for osteoarthritis

• Expansion of HA product portfolio into new therapeutic areas like wound healing

Download FREE Sample Report:
Global Pharmaceutical Grade Hyaluronic Acid Market – View in Detailed Research Report

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6️⃣ 5. Altergon Italia

Headquarters: Morra De Sanctis, Italy
Key Offering: IRCAREL® viscosupplementation, Medical Grade HA for Ophthalmology

Altergon Italia specializes in the research, development, and manufacturing of medical devices and pharmaceutical products, with a core expertise in hyaluronic acid. The company’s pharmaceutical-grade HA is a key component in its orthopedic and ophthalmic solutions, adhering to strict pharmacopoeia standards.

Innovation & Development Initiatives:

• Proprietary purification processes to eliminate animal-derived residues

• Focus on combination products that integrate HA with other therapeutic agents

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5️⃣ 6. Contipro

Headquarters: Dolní Dobrouč, Czech Republic
Key Offering: Hyaluronic Acid of Ultra-High Purity, Custom HA Derivatives

Contipro is a vertically integrated biotechnology company renowned for its innovation in hyaluronic acid and its derivatives. It controls the entire production chain from fermentation to finished product, supplying the global market with specialized, high-molecular-weight pharmaceutical-grade HA.

Innovation & Development Initiatives:

• World-leading production of ultra-high molecular weight HA (over 3 MDa)

• Extensive portfolio of customized HA derivatives for advanced drug delivery systems

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4️⃣ 7. SYMATESE

Headquarters: Chaponost, France
Key Offering: HYAIS® Biomedical Polymers, HA for Surgical Applications

SYMATESE specializes in developing and manufacturing biomaterials for the medical device industry. The company produces highly purified, pharmaceutical-grade hyaluronic acid used in a wide array of medical applications, including adhesion barriers, viscoelastic aids in surgery, and advanced wound care products.

Innovation & Development Initiatives:

• Expertise in chemical modification of HA to create novel biomaterials with tailored properties

• Strong focus on regulatory compliance for medical devices (CE Mark, FDA approvals)

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3️⃣ 8. RiverPharma

Headquarters: Bussolengo, Italy
Key Offering: HYMOVIS® viscosupplement, GMP-certified HA Production

RiverPharma is an Italian company dedicated to the development of innovative products in orthobiology and regenerative medicine. It operates a GMP-certified facility for the production of its flagship HYMOVIS® product, a hydrogel based on hyaluronic acid for the treatment of osteoarthritis.

Innovation & Development Initiatives:

• Patented HYAFF® technology for creating HYMOVIS®, a high viscosity hydrogel

• Clinical studies demonstrating the efficacy and longevity of its proprietary HA formulation

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2️⃣ 9. Fidia Farmaceutici

Headquarters: Abano Terme, Italy
Key Offering: HYALGAN® viscosupplement, HA for Ophthalmology and Wound Care

Fidia Farmaceutici is a historic and globally recognized leader in hyaluronic acid-based therapeutics. It was among the first companies to develop and commercialize HA for medical use. Its pharmaceutical-grade HA is the cornerstone of its extensive product portfolio in orthopedics, ophthalmology, and aesthetics.

Innovation & Development Initiatives:

• Pioneer in the research and clinical application of hyaluronic acid for over 50 years

• Continuous optimization of production processes to ensure batch-to-batch consistency and high purity

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1️⃣ 10. Freshine Chem

Headquarters: Shandong, China
Key Offering: Cosmetic & Pharmaceutical Grade Sodium Hyaluronate

Freshine Chem is a significant manufacturer of hyaluronic acid in China, supplying both cosmetic and pharmaceutical grades to domestic and international markets. The company has invested in scaling up its production capacity to meet the growing global demand for high-purity HA.

Innovation & Development Initiatives:

• Expansion of production facilities to increase output of pharmaceutical-grade HA

• Focus on cost-effective manufacturing while maintaining stringent quality control standards

Get Full Report Here:
Global Pharmaceutical Grade Hyaluronic Acid Market – View in Detailed Research Report

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🔬 Outlook: The Future of Pharmaceutical Grade Hyaluronic Acid is Advanced and Targeted

The pharmaceutical grade hyaluronic acid market is experiencing a significant transformation. While traditional applications in viscosupplementation and ophthalmic surgery remain strong, the industry is heavily investing in novel drug delivery systems, regenerative medicine, and personalized therapeutics.

📈 Key Trends Shaping the Market:

• R&D into HA-based nanoparticles and hydrogels for targeted cancer therapy

• Growing adoption of combination products integrating HA with growth factors or other APIs

• Increasing regulatory scrutiny and harmonization of standards for HA-based medical devices and drugs

• Expansion into emerging applications in neurology and cardiovascular diseases

Get Full Report Here:
Global Pharmaceutical Grade Hyaluronic Acid Market – View in Detailed Research Report

The companies listed above are not only supplying a critical biomaterial—they are at the forefront of innovation in modern medicine, enabling new treatments that improve patient outcomes across a spectrum of diseases.