The Global Protein G, L, and A Resin Market was valued at USD 801.4 Million in 2022 and is projected to reach USD 1334.9 Million by 2029, growing at a Compound Annual Growth Rate (CAGR) of 7.6% during the forecast period. This robust growth is fueled by the expanding monoclonal antibody (mAb) therapeutics market, increasing investments in biopharmaceutical R&D, and the critical role these affinity resins play in downstream purification processes.

As the biopharmaceutical industry accelerates toward more targeted and complex biologic drugs, the demand for high-purity antibody purification is paramount. In this blog, we profile the Top 10 Companies in the Protein G, L, and A Resin Industry—a collection of life science giants and specialist suppliers that are enabling the development and manufacturing of next-generation therapies.

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🔟 1. Cytiva (Danaher)

Headquarters: Marlborough, Massachusetts, USA
Key Offering: MabSelect™, MabSelect SuRe™, rProtein A Sepharose™ FF

Cytiva, a global life sciences leader under Danaher, is a dominant force in chromatography resins. Its MabSelect family of Protein A resins is an industry standard for monoclonal antibody purification, renowned for high binding capacity, stability, and scalability from research to commercial manufacturing.

Innovation and Capacity:

• Continuous investment in next-generation resins with improved alkali stability

• Global manufacturing footprint to ensure robust supply chains

• Integrated solutions including columns, systems, and services

Download FREE Sample Report: Protein G, L, And A Resin Market – View in Detailed Research Report

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9️⃣ 2. Merck KGaA

Headquarters: Darmstadt, Germany
Key Offering: Eshmuno® A, ProSep® vA Ultra, Protein G Sepharose® 4 Fast Flow

Merck’s Life Science business offers a comprehensive portfolio of separation and purification products. Its Eshmuno® A resins are designed for high productivity and cost-effectiveness in large-scale antibody production, while its legacy ProSep® products are widely used across the industry.

Innovation and Capacity:

• Focus on high-capacity, high-flow-rate resins to improve process economics

• Strong presence in both the API and finished drug substance markets

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8️⃣ 3. Purolite Corporation

Headquarters: King of Prussia, Pennsylvania, USA
Key Offering: Praesto® Protein A, Jetted A50, Gold Bio A50

Purolite, an Ecolab company, is a leading manufacturer of chromatography resins and a key supplier to the biopharmaceutical industry. The company’s Praesto® platform offers advanced agarose-based Protein A resins known for their rigidity and high dynamic binding capacity.

Innovation and Capacity:

• Specialization in rigid resin beads for high-pressure liquid chromatography

• Significant capacity expansion to meet growing global demand

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7️⃣ 4. Thermo Fisher Scientific

Headquarters: Waltham, Massachusetts, USA
Key Offering: Pierce™ Protein A, G, L Agarose, NAb™ Protein A Plus Spin Columns

Thermo Fisher Scientific provides a wide array of protein resein products tailored for both research-scale and process development applications. Their offerings are integral to workflows in academic labs, biotech startups, and large Pharma companies for antibody purification and detection.

Innovation and Capacity:

• Broad portfolio supporting the entire research and development lifecycle

• Strong distribution network ensuring product accessibility worldwide

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6️⃣ 5. Repligen Corporation

Headquarters: Waltham, Massachusetts, USA
Key Offering: OPUS® Prepacked Chromatography Columns, Protein A Agarose Resins

Repligen is a rapidly growing provider of bioprocessing technologies. While known for its prefilled columns, the company has been expanding its capture in the resin market through acquisitions and internal development, focusing on enabling intensified and continuous bioprocessing.

Innovation and Capacity:

• Strategic focus on integrated solutions for downstream processing

• Investment in technologies supporting continuous manufacturing

Download FREE Sample Report: Protein G, L, And A Resin Market – View in Detailed Research Report

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5️⃣ 6. Bio-Rad Laboratories

Headquarters: Hercules, California, USA
Key Offering: Affi-Gel® Protein A, Affi-Prep® Protein A Support, IgG Binding Protein L Agarose

Bio-Rad is a longstanding leader in life science research and clinical diagnostics. Its Affi-Gel and Affi-Prep resins are workhorses in research laboratories globally, providing reliable and efficient methods for antibody purification and immunoprecipitation.

Innovation and Capacity:

• Strong reputation for quality and consistency in research-grade resins

• Extensive support and technical resources for the scientific community

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4️⃣ 7. GenScript Biotech Corporation

Headquarters: Piscataway, New Jersey, USA
Key Offering: Protein A MagBeads, Protein G Agarose, Recombinant Protein L

GenScript is a leading life sciences contract research and development organization. It offers a range of affinity resins and magnetic beads, leveraging its expertise in recombinant protein production to provide high-quality, cost-effective alternatives for antibody purification.

Innovation and Capacity:

• Focus on recombinant technologies for consistent resin performance

• Growing capabilities in magnetic separation technologies

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3️⃣ 8. Abcam plc

Headquarters: Cambridge, United Kingdom
Key Offering: Protein A, G, L Agarose Conjugates, Spin Kits

Abcam, a global leader in the supply of protein research tools, provides high-quality affinity resins primarily for research and diagnostic applications. Their products are essential for scientists performing antibody purification, co-immunoprecipitation, and pull-down assays.

Innovation and Capacity:

• Integration of resins into user-friendly kits and workflows

• Strong focus on the research reagent market with validated performance

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2️⃣ 9. Takara Bio Inc.

Headquarters: Kusatsu, Shiga, Japan
Key Offering: Protein A Sepharose®, Streptavidin Magnetic Beads, Cellulose Resin

Takara Bio is a prominent biotechnology company in Asia, offering a variety of life science research tools, including chromatography resins. The company serves the growing APAC biopharmaceutical market with reliable products for basic research and process development.

Innovation and Capacity:

• Significant market share and manufacturing strength in the Asia-Pacific region

• Broad portfolio supporting molecular biology and protein research

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1️⃣ 10. PerkinElmer, Inc.

Headquarters: Waltham, Massachusetts, USA
Key Offering: Protein A Agarose, Acetylcholinesterase Resins

PerkinElmer provides solutions for the diagnostics, life sciences, and applied markets. Its product portfolio includes affinity resins used in research settings for purifying antibodies and other proteins, complementing its broader offering in detection and analysis.

Innovation and Capacity:

• Focus on integrating purification with downstream analytical workflows

• Strong application support for diagnostic and research customers

Get Full Report Here: Protein G, L, And A Resin Market – View in Detailed Research Report

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🔬 Outlook: The Future of Antibody Purification Is High-Throughput and Continuous

The Protein G, L, and A resin market is undergoing a significant evolution. While batch chromatography remains the standard, the industry is rapidly adopting new modalities to increase efficiency, reduce costs, and improve sustainability in biomanufacturing.

📈 Key Trends Shaping the Market:

• Shift towards continuous bioprocessing driving demand for more robust and durable resins

• Growing adoption of single-use technologies and pre-packed columns

• Rising demand for non-Protein A alternatives (like Protein L and G) for purifying novel antibody formats (e.g., bispecifics, Fab fragments)

• Increasing focus on resin recycling and lifetime extension to lower the cost of goods

Get Full Report Here: Protein G, L, And A Resin Market – View in Detailed Research Report

The companies listed above are not only supplying critical purification tools—they are enablers of the biologics revolution, ensuring that life-saving therapies can be manufactured safely, efficiently, and at scale.