The Global Pharma Grade Hyaluronic Acid API Market was valued at USD 179.86 Million in 2023 and is projected to reach USD 323.88 Million by 2029, growing at a Compound Annual Growth Rate (CAGR) of 10.30% during the forecast period (2024–2029). This significant growth is primarily driven by the rising global prevalence of osteoarthritis, an expanding geriatric population, increasing demand for ophthalmic surgeries, and the accelerating adoption of advanced dermal fillers in aesthetic medicine.

As the biopharmaceutical industry increasingly relies on high-purity, bioactive ingredients, the spotlight is on the key manufacturers who are driving innovation, ensuring stringent quality control, and scaling production to meet global demand. In this blog, we profile the Top 10 Companies in the Pharma Grade Hyaluronic Acid API Industry—a mix of established biologics giants, specialized fermenters, and innovative biotechnology firms shaping the future of therapeutic and medical device applications.

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Global Pharma Grade Hyaluronic Acid API Market – View in Detailed Research Report

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🔟 1. Bloomage Biotech

Headquarters: Jinan, Shandong, China
Key Offering: High-Purity Hyaluronic Acid API, Sodium Hyaluronate, Oligo-HA

Bloomage Biotech is the world’s largest producer of hyaluronic acid, with a significant market share in pharmaceutical-grade products. The company utilizes advanced microbial fermentation technology to produce HA with a wide range of molecular weights, catering to injectables, ophthalmology, and other medical applications. Their extensive R&D focuses on novel HA derivatives and drug delivery systems.

Innovation and Production Focus:

• Global production capacity exceeding 400 tonnes annually

• Pioneering cross-linked and chemically modified HA for advanced therapeutics

• Strong vertical integration from raw materials to finished APIs

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9️⃣ 2. Kewpie Corporation

Headquarters: Tokyo, Japan
Key Offering: Q-Matrix® HA, Sodium Hyaluronate BP/EP/USP

Kewpie, a renowned Japanese food and ingredients company, is also a leading global supplier of high-quality hyaluronic acid. Their pharmaceutical division produces HA APIs that meet stringent international pharmacopeia standards (USP, EP, JP). Kewpie’s HA is widely used in intra-articular injections for osteoarthritis and ophthalmic viscoelastic devices.

Innovation and Production Focus:

• Decades of expertise in HA purification and characterization

• Strategic focus on high-value, medical-grade applications

• Commitment to consistent quality and regulatory compliance

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Global Pharma Grade Hyaluronic Acid API Market – View in Detailed Research Report

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8️⃣ 3. Contipro

Headquarters: Dolní Dobrouč, Czech Republic
Key Offering: Hyaluronic Acid API, Hymovis® (for orthopedics), ACP® gels

Contipro is a European leader in the research, development, and production of hyaluronic acid and its derivatives. The company is renowned for its innovative portfolio, including high molecular weight HA for viscosupplementation and proprietary technologies for creating unique HA-based biomaterials. They serve global pharmaceutical and medical device companies.

Innovation and Production Focus:

• Strong R&D pipeline for next-generation HA medical devices

• GMP-certified manufacturing facilities supplying global markets

• Development of synergistic HA-based combination products

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7️⃣ 4. Seikagaku Corporation

Headquarters: Tokyo, Japan
Key Offering: ARTZ® (Sodium Hyaluronate Injection), Ophthalmic HA, Research-grade Glycosaminoglycans

Seikagaku is a Japanese pharmaceutical company with a long-standing legacy in glycosaminoglycan research, including hyaluronic acid. They are a key supplier of HA APIs for their own branded pharmaceuticals, such as ARTZ for knee osteoarthritis, and for other manufacturers, with a strong emphasis on purity and biological activity.

Innovation and Production Focus:

• Proprietary purification processes ensuring ultra-pure HA

• Extensive clinical data supporting the efficacy of their HA formulations

• Focus on niche, high-barrier-to-entry therapeutic areas

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6️⃣ 5. Fidia Farmaceutici S.p.A.

Headquarters: Abano Terme, Italy
Key Offering: Hyaluronic Acid API, HYA-JOINT® products, Regenerative Medicine Solutions

Fidia Farmaceutici is a major international pharmaceutical group entirely dedicated to hyaluronic acid. With over 50 years of experience, Fidia has pioneered many HA-based medical products, particularly in orthopedics and wound care. Their API division supplies high-quality HA for a range of pharmaceutical and advanced therapy applications.

Innovation and Production Focus:

• World’s first company to develop HA for orthopedic use

• Integrated approach from API manufacturing to finished drug product

• Ongoing research in HA for tissue engineering and regenerative medicine

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5️⃣ 6. HTL Biotechnology

Headquarters: Javant, France
Key Offering: Javoselect® HA, HYAJE® Injectable Gel, Custom HA Polymers

HTL Biotechnology is a French company specializing in the development and production of high-purity hyaluronic acid for medical and aesthetic applications. They are known for their Javoselect® portfolio, which includes HA APIs with specific molecular weights and properties tailored for pharmaceutical clients, particularly in the field of viscosupplementation.

Innovation and Production Focus:

• Expertise in controlling HA polymer characteristics (size, structure)

• Strategic partnerships with leading medical device companies

• Focus on traceability and biocompatibility of raw materials

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Global Pharma Grade Hyaluronic Acid API Market – View in Detailed Research Report

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4️⃣ 7. Givaudan Active Beauty

Headquarters: Vernier, Switzerland
Key Offering: Hyaluronic Acid Fractions, Hyaskin™, Prodizia™

While primarily known in the cosmetics sector, Givaudan’s Active Beauty division is a significant player in the supply chain for pharmaceutical-grade HA ingredients, especially lower molecular weight fractions used in advanced skincare and some topical pharmaceutical formulations. Their expertise in bio-fermentation and ingredient science is highly regarded.

Innovation and Production Focus:

• Advanced biotechnological platforms for HA production

• Development of patented HA derivatives with enhanced bioavailability

• Sustainable and natural sourcing and production processes

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3️⃣ 8. Shandong Galaxy Bio-Tech Co., Ltd.

Headquarters: Linyi, Shandong, China
Key Offering: Pharmaceutical Grade Sodium Hyaluronate, Hyaluronic Acid Powder

Shandong Galaxy Bio-Tech is a prominent Chinese manufacturer of hyaluronic acid, supplying APIs to both domestic and international markets. The company has invested significantly in scaling up its microbial fermentation capabilities to produce high-purity HA that meets the requirements of pharmaceutical and nutraceutical customers.

Innovation and Production Focus:

• Large-scale production capacity with cost-competitive advantages

• Focus on expanding regulatory approvals in key international markets

• Investment in R&D for new HA applications in drug delivery

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2️⃣ 9. HAIWEI

Headquarters: Jinan, Shandong, China
Key Offering: Cosmetic & Pharma Grade HA, Oligo-Hyaluronic Acid

HAIWEI is a specialized manufacturer of hyaluronic acid with a growing presence in the pharmaceutical API sector. The company focuses on producing a range of molecular weights and is building a reputation for reliability and quality consistency, serving an expanding global client base.

Innovation and Production Focus:

• Modern fermentation and downstream processing facilities

• Strategic growth targeting the pharmaceutical segment

• Commitment to stringent quality management systems

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1️⃣ 10. AWA Biopharm

Headquarters: Shandong, China
Key Offering: Hyaluronic Acid API, Sodium Hyaluronate for Medical Use

AWA Biopharm is an emerging player dedicated to the production and development of hyaluronic acid and other biological products. The company is focusing on advancing its technological capabilities to produce pharma-grade HA that complies with international standards, positioning itself as a key supplier for the growing biopharma market.

Innovation and Production Focus:

• Investment in R&D for high-purity, low-endotoxin HA production

• Building partnerships with pharmaceutical companies for custom synthesis

• Expanding production capacity to meet increasing global demand

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Global Pharma Grade Hyaluronic Acid API Market – View in Detailed Research Report

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🔬 Outlook: The Future of Pharma Grade Hyaluronic Acid API is Precision and Personalization

The Pharma Grade Hyaluronic Acid API market is undergoing a significant transformation. While traditional high molecular weight HA for viscosupplementation remains a cornerstone, the industry is heavily investing in next-generation HA derivatives, targeted drug delivery systems, and regenerative medicine applications.

📈 Key Trends Shaping the Market:

• Rising demand for customized molecular weight HA for specific therapeutic indications

• Expansion of HA applications in novel drug delivery platforms and combination products

• Increasing regulatory scrutiny and emphasis on cGMP compliance for APIs

• Strategic collaborations between API manufacturers and pharmaceutical companies for co-development

Get Full Report Here:
Global Pharma Grade Hyaluronic Acid API Market – View in Detailed Research Report

The companies listed above are not only supplying a critical biopharmaceutical ingredient—they are actively pioneering the next wave of HA-based therapeutics that promise enhanced efficacy and improved patient outcomes across a spectrum of medical fields.