The Global 5-Aminolevulinic Acid (5-ALA) Market was valued at USD 167.5 Million in 2022 and is projected to reach USD 308.3 Million by 2030, growing at a Compound Annual Growth Rate (CAGR) of 9.1% during the forecast period (2023–2030). This robust growth is fueled by the expanding applications of 5-ALA in photodynamic therapy (PDT) for cancer treatment, its increasing use as a powerful biostimulant in agriculture, and advancements in manufacturing technologies that are improving accessibility and reducing costs.

As the healthcare and agriculture sectors increasingly embrace biologically derived solutions for diagnostics, treatment, and crop enhancement, the demand for key intermediates like 5-ALA is soaring. In this blog, we profile the Top 10 Companies in the 5-Aminolevulinic Acid Industry—a dynamic mix of established pharmaceutical ingredient suppliers, innovative biotech firms, and agrochemical specialists driving the market forward.

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🔟 1. Midas Pharma GmbH

Headquarters: Ingelheim am Rhein, Germany
Key Offering: Pharmaceutical-grade 5-ALA (HCl and free base), Custom Synthesis

Midas Pharma is a leading global supplier of active pharmaceutical ingredients (APIs) and intermediates, with a strong focus on high-purity 5-Aminolevulinic Acid. The company serves the pharmaceutical industry with cGMP-compliant products, supporting the development of both generic and innovative photodynamic therapy drugs.

Key Growth Strategies:

• Expansion of cGMP manufacturing capacity for high-purity 5-ALA

• Strategic partnerships with pharmaceutical companies for drug development

• Investment in R&D for novel 5-ALA derivatives and formulations

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5-Aminolevulinic Acid Market – View in Detailed Research Report

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9️⃣ 2. Medac GmbH

Headquarters: Wedel, Germany
Key Offering: 5-ALA (as Aminolevulinic acid hydrochloride), Finished Pharmaceutical Products

Medac is a specialty pharmaceutical company with a significant presence in the 5-ALA market, primarily through its proprietary product, Gliolan® (5-aminolevulinic acid HCl). This product is approved in Europe for the visualization of malignant tissue during surgery for malignant glioma, establishing Medac as a key player in the neurological oncology segment.

Key Growth Strategies:

• Geographic expansion of Gliolan® into new regulatory markets

• Clinical development of 5-ALA for new oncology indications

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8️⃣ 3. Sobeo Biotech (Shandong) Co., Ltd.

Headquarters: Shandong, China
Key Offering: 5-ALA (Purity 95%-98%), Agricultural-grade 5-ALA

Sobeo Biotech is a major Chinese manufacturer of 5-Aminolevulinic Acid, specializing in both standard and high-purity grades. The company has a strong export footprint and caters to the growing demand for 5-ALA as a plant growth regulator and biostimulant in the agricultural sector, in addition to pharmaceutical applications.

Key Growth Strategies:

• Scaling up fermentation-based production to reduce costs

• Developing tailored 5-ALA formulations for specific crops

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7️⃣ 4. NMT Biotech (Shanghai) Co., Ltd.

Headquarters: Shanghai, China
Key Offering: High-Purity 5-ALA HCl, Research-grade 5-ALA

NMT Biotech focuses on the research, development, and production of high-value biochemicals, with 5-ALA being a core product. The company supplies to research institutions, diagnostic manufacturers, and pharmaceutical companies globally, emphasizing quality control and technical support.

Key Growth Strategies:

• Enhancing purification technologies to achieve >99% purity levels

• Building a global distribution network for research and industrial customers

Download FREE Sample Report:
5-Aminolevulinic Acid Market – View in Detailed Research Report

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6️⃣ 5. Natural Field Co., Ltd.

Headquarters: Zhejiang, China
Key Offering: 5-ALA for Agriculture, Fertilizer Additives

Natural Field is a prominent supplier of 5-Aminolevulinic Acid with a strong focus on the agriculture industry. The company produces cost-effective 5-ALA that is used to enhance photosynthesis, improve stress tolerance, and increase crop yields, positioning it as a key enabler of sustainable farming practices.

Key Growth Strategies:

• Marketing 5-ALA as a core component of integrated crop management solutions

• Collaborating with agrochemical companies to develop combination products

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5️⃣ 6. Neopharma LLC

Headquarters: Abu Dhabi, UAE
Key Offering: APIs, including 5-Aminolevulinic Acid

Neopharma is a leading pharmaceutical manufacturer in the Middle East and North Africa (MENA) region, with a growing portfolio of APIs. The company’s involvement in the 5-ALA market supports regional healthcare needs and its strategic aim to become a global supplier of high-quality pharmaceutical ingredients.

Key Growth Strategies:

• Leveraging its regional manufacturing hub to serve emerging markets

• Pursuing international regulatory certifications for its API facilities

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4️⃣ 7. Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.

Headquarters: Shanghai, China
Key Offering: 5-ALA-based APIs, Finished Dosage Forms

Fudan-Zhangjiang is a biopharmaceutical company with significant expertise in photodynamic therapy. It has developed its own 5-ALA-based drug, significantly contributing to the domestic Chinese market. The company integrates R&D, manufacturing, and commercialization, giving it a strong vertical presence in the 5-ALA value chain.

Key Growth Strategies:

• Expanding the clinical applications of its proprietary 5-ALA formulations

• Capitalizing on China’s growing healthcare expenditure and oncology focus

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3️⃣ 8. Xinlian Biochemical Co., Ltd.

Headquarters: Zhejiang, China
Key Offering: Technical and Agriculture-grade 5-ALA

Xinlian Biochemical is a chemical manufacturer with a focus on biochemical products for various industries. The company produces 5-Aminolevulinic Acid primarily for agricultural applications, offering competitive pricing and reliable supply to the global market.

Key Growth Strategies:

• Optimizing chemical synthesis processes to maintain cost leadership

• Expanding its product portfolio to include value-added bio-stimulants

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2️⃣ 9. SBI Holdings, Inc. (SBI ALApromo Co., Ltd.)

Headquarters: Tokyo, Japan
Key Offering: 5-ALA supplements, Consumer Health Products

SBI Holdings, through its subsidiary SBI ALApromo, has a unique position in the market, focusing on the consumer health and wellness applications of 5-ALA. The company markets dietary supplements containing 5-ALA, targeting energy metabolism and anti-aging, which represents a significant and growing consumer segment.

Key Growth Strategies:

• Aggressive marketing of 5-ALA’s health benefits in the nutraceutical space

• Research into new health indications for 5-ALA supplementation

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1️⃣ 10. Other Key Global Suppliers and Innovators

Composition: A diverse group of specialized chemical suppliers and research-centric firms.
Key Offering: Research chemicals, Custom synthesis services, Niche applications.

This category encompasses a range of smaller but critical players, including Sigma-Aldrich (Merck KGaA), Tokyo Chemical Industry (TCI), and other fine chemical suppliers that provide high-purity 5-ALA for research and development purposes. These companies are essential for fueling innovation by supplying the scientific community with the materials needed for discovering new applications.

Key Growth Strategies:

• Supporting academic and industrial R&D with high-quality materials

• Developing proprietary synthesis and purification methods

Get Full Report Here:
5-Aminolevulinic Acid Market – View in Detailed Research Report

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🔬 Outlook: The Future of 5-Aminolevulinic Acid is Multi-Dimensional

The 5-Aminolevulinic Acid market is at a pivotal juncture, evolving from a niche biochemical to a versatile compound with cross-industry appeal. While its established role in cancer diagnosis and treatment continues to be a primary driver, its potential in sustainable agriculture and consumer health is unlocking new growth avenues.

📈 Key Trends Shaping the Market:

• Expansion in Oncology: Ongoing clinical trials for 5-ALA in new cancer types, including bladder and skin cancers, are expected to significantly widen its medical applications.

• Agriculture 4.0: The integration of 5-ALA into precision agriculture and smart farming solutions as a natural yield-enhancing agent.

• Technological Advancements: A shift from traditional chemical synthesis to more efficient and sustainable fermentation processes, which is lowering production costs and improving scalability.

• Regulatory Support: Increasing government approvals for 5-ALA-based drugs and agricultural products, particularly in Asia-Pacific markets.

Get Full Report Here:
5-Aminolevulinic Acid Market – View in Detailed Research Report

The companies profiled above are not merely suppliers; they are innovators and enablers, driving the adoption of 5-ALA across healthcare and agriculture and contributing to a healthier and more sustainable future.