The Global Acetaminophen Injection Market was valued at USD 1008.02 million in 2023 and is projected to reach USD 1102.21 million by 2029, exhibiting a Compound Annual Growth Rate (CAGR) of 1.50% during the forecast period (2024–2029). This steady growth is primarily driven by the rising prevalence of pain-related conditions, an increase in surgical procedures, and the expanding adoption of intravenous pain management in hospital and clinical settings due to its rapid onset of action.

As global healthcare systems prioritize effective and safe analgesic solutions, the demand for reliable and high-quality injectable acetaminophen continues to escalate. In this blog, we profile the Top 10 Companies in the Acetaminophen Injection Market—a diverse mix of pharmaceutical giants, specialized manufacturers, and generic drug leaders shaping the landscape of parenteral pain management.

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🔟 1. Mallinckrodt Pharmaceuticals

Headquarters: Staines-upon-Thames, United Kingdom (Global Specialty generics headquarters)
Key Product: Ofirmev® (Acetaminophen) Injection

Mallinckrodt is a pioneer and a dominant force in the branded acetaminophen injection market. The company’s flagship product, Ofirmev®, was the first intravenous acetaminophen approved by the FDA. It is widely used in hospital settings for the management of mild to moderate pain and the reduction of fever.

Key Market Strengths:

• First-mover advantage with Ofirmev® in the US market

• Established distribution network across major hospitals

• Ongoing clinical studies to expand indications

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9️⃣ 2. B. Braun Medical Inc.

Headquarters: Bethlehem, Pennsylvania, USA
Key Product: Acetaminophen Injection, USP

B. Braun is a leading global supplier of healthcare products and services, with a strong presence in the generic injectables market. The company offers a USP-compliant Acetaminophen Injection that provides a cost-effective alternative to branded options, catering to the needs of healthcare systems focused on efficiency.

Key Market Strengths:

• Strong manufacturing capabilities and quality assurance

• Extensive portfolio of compatible infusion systems and devices

• Focus on safety and ease of use for healthcare professionals

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8️⃣ 3. Fresenius Kabi

Headquarters: Bad Homburg, Germany
Key Product: Paracetamol Fresenius (Acetaminophen Injection)

Fresenius Kabi is a global healthcare company specializing in lifesaving medicines and technologies for infusion, transfusion, and clinical nutrition. Its acetaminophen injection is a critical part of its broad hospital pharmacy portfolio, serving markets in Europe, Asia, and the Americas.

Key Market Strengths:

• Global manufacturing footprint ensuring supply chain resilience

• Integration with a wide range of hospital care products

• Commitment to high-quality, affordable generic medicines

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7️⃣ 4. Perrigo Company plc

Headquarters: Dublin, Ireland (Operational headquarters in Grand Rapids, Michigan, USA)
Key Product: Acetaminophen Injection

Perrigo is one of the world’s largest manufacturers of over-the-counter (OTC) healthcare products and generic prescription pharmaceuticals. The company’s entry into the acetaminophen injection market strengthens its position as a provider of essential medicines across multiple dosage forms.

Key Market Strengths:

• Extensive experience in pharmaceutical manufacturing and logistics

• Strategic focus on expanding its prescription portfolio

• Strong retail and institutional customer base

Download FREE Sample Report:
Global Acetaminophen Injection Market – View in Detailed Research Report

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6️⃣ 5. Pfizer (Hospira)

Headquarters: New York, New York, USA
Key Product: Acetaminophen Injection (legacy Hospira products)

Following its acquisition of Hospira, Pfizer became a powerhouse in the sterile injectables market. The company markets a generic acetaminophen injection, leveraging Hospira’s established manufacturing expertise and global supply chain to serve a broad customer base.

Key Market Strengths:

• Vast global commercial infrastructure and reach

• Heritage of quality from Hospira’s injectables legacy

• Robust R&D capabilities for product development and enhancement

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5️⃣ 6. Sandoz AG (a Novartis division)

Headquarters: Basel, Switzerland
Key Product: Generic Acetaminophen/PARACETAMOL Injection

Sandoz is a global leader in generic pharmaceuticals and biosimilars. The company offers a high-quality, generic acetaminophen injection, contributing to market accessibility and affordability. Its global presence ensures reliable supply to hospitals worldwide.

Key Market Strengths:

• Leadership in global generics and biosimilars

• Strong regulatory expertise for market approvals worldwide

• Commitment to increasing patient access to essential medicines

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4️⃣ 7. Accord Healthcare

Headquarters: Dublin, Ireland (Operational HQ in Durham, North Carolina, USA)
Key Product: Paracetamol Injection

Accord Healthcare is one of Europe’s fastest-growing pharmaceutical companies with a significant and expanding presence in the US. The company provides a generic paracetamol injection, focusing on delivering consistent quality and value to healthcare providers.

Key Market Strengths:

• Rapidly expanding product portfolio and geographic footprint

• Focus on niche and hard-to-manufacturer sterile injectables

• Agile and responsive supply chain

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3️⃣ 8. Terumo Corporation

Headquarters: Tokyo, Japan
Key Product: Acetaminophen Injection (primarily for Asian markets)

Terumo is a leading global medical device manufacturer that also has a presence in the pharmaceutical space. The company offers acetaminophen injection, particularly strengthening its position in the Asia-Pacific region where it has a strong distribution network.

Key Market Strengths:

• Dominant presence in the APAC medical and pharmaceutical markets

• Synergy between drug delivery devices and pharmaceutical products

• Strong reputation for quality and innovation

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2️⃣ 9. AuroMedics Pharma LLC (Aurobindo Pharma USA)

Headquarters: East Windsor, New Jersey, USA
Key Product: Acetaminophen Injection, USP

AuroMedics Pharma, a wholly-owned subsidiary of Aurobindo Pharma, specializes in developing, manufacturing, and marketing injectable products. The company is a key supplier of generic acetaminophen injection in the US market, emphasizing quality and affordability.

Key Market Strengths:

• Backing of Aurobindo Pharma’s extensive R&D and manufacturing prowess

• Growing portfolio of sterile injectable products

• Cost-competitive manufacturing

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1️⃣ 10. AdvaCare Pharma

Headquarters: Denver, Colorado, USA
Key Product: Paracetamol/ Acetaminophen Injections

AdvaCare Pharma is a global manufacturer and supplier of pharmaceuticals, medical devices, and nutraceuticals. The company supplies acetaminophen injection to various international markets, focusing on meeting the demands of emerging economies and specific regional needs.

Key Market Strengths:

• Strategic focus on emerging markets in Africa, Asia, and Latin America

• Flexible manufacturing and regulatory support for multiple countries

• Diverse product portfolio catering to hospital essentials

Read Full Report:
Global Acetaminophen Injection Market – View in Detailed Research Report

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🏥 Outlook: The Future of Acetaminophen Injection is Evolving with Healthcare Needs

The acetaminophen injection market is experiencing a gradual but significant transformation. While the product remains a cornerstone of non-opioid pain management, the industry is focusing on manufacturing excellence, supply chain reliability, and expanding access in underserved markets.

📈 Key Trends Shaping the Market:

• Increasing preference for IV analgesics in postoperative care for faster relief

• Growing generic competition leading to price optimization and improved accessibility

• Rising healthcare expenditure and surgical volumes in emerging economies

• Stringent regulatory scrutiny ensuring high-quality manufacturing standards

Read Full Report:
Global Acetaminophen Injection Market – View in Detailed Research Report

The companies listed above are not only supplying a critical medication—they are enabling effective pain management protocols and contributing to the advancement of global healthcare standards.