The Global Trehalase Market was valued at US$ 1462.4 million in 2022 and is projected to reach US$ 2282.4 million by 2029, growing at a Compound Annual Growth Rate (CAGR) of 6.6% during the forecast period (2022–2029). This growth is being driven by rising demand for natural carbohydrates in food preservation, expanding applications in pharmaceutical formulations for bioactive substance protection, and the increasing focus on trehalose-derived products in emerging markets, particularly in Asia-Pacific and North America, where regulatory support for safe additives is strengthening.

As the biotechnology and food industries evolve toward sustainable and effective stabilization solutions, the emphasis falls on leading manufacturers who are advancing enzyme production, purification techniques, and versatile applications. In this blog, we profile the Top 10 Companies in the Trehalase Market—a blend of global food giants, biotech specialists, and chemical innovators shaping the landscape of enzyme-based solutions for everyday and specialized uses.

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🔟 1. Cargill Incorporated

Headquarters: Minnetonka, Minnesota, USA
Key Offering: Food Grade Trehalase, Enzyme Blends for Preservation

Cargill stands as a dominant force in the global ingredients market, with a strong emphasis on enzymes like trehalase used in food processing. The company supplies high-purity trehalase for applications in baked goods, beverages, and dairy products, leveraging its extensive network to ensure consistent quality and supply chain reliability for manufacturers worldwide.

Innovation Initiatives:

• Development of trehalase-integrated formulations for enhanced shelf-life in processed foods

• Collaborations with food tech firms to explore natural stabilizers

• Investments in sustainable sourcing of microbial-derived enzymes

Download FREE Sample Report: Trehalase Market – View in Detailed Research Report

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9️⃣ 2. Santa Cruz Biotechnology

Headquarters: Dallas, Texas, USA
Key Offering: Pharmaceutical Grade Trehalase, Research-Grade Enzymes

Santa Cruz Biotechnology specializes in high-quality antibodies and reagents, including trehalase for laboratory and pharmaceutical research. Their products support studies on carbohydrate metabolism and are integral in developing therapeutics where trehalose acts as a protectant for proteins and cells during formulation and storage.

Innovation Initiatives:

• Advancements in recombinant trehalase production for biotech applications

• Partnerships with academic institutions for enzyme characterization

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8️⃣ 3. Horizon Discovery (formerly GE Dharmacon)

Headquarters: Cambridge, United Kingdom
Key Offering: Trehalase for Gene Editing and Cell Culture

Horizon Discovery, part of PerkinElmer, excels in genomics tools and reagents, offering trehalase variants for cell-based assays and cryopreservation. The company’s focus on precision medicine drives its role in providing enzymes that stabilize biological materials during experimental processes.

Innovation Initiatives:

• Integration of trehalase in CRISPR-related workflows for better yields

• Research into enzyme modifications for industrial-scale pharma production

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7️⃣ 4. Cayman Chemical

Headquarters: Ann Arbor, Michigan, USA
Key Offering: Biochemical Trehalase, Assay Kits

Cayman Chemical is renowned for its biochemical tools, supplying trehalase for metabolic studies and drug discovery. Their products aid in understanding trehalose’s role in stress response mechanisms, benefiting both food science and medicinal chemistry sectors with reliable, assay-ready reagents.

Innovation Initiatives:

• Expansion of trehalase assay portfolios for high-throughput screening

• Development of stable enzyme formulations for long-term storage

Download FREE Sample Report: Trehalase Market – View in Detailed Research Report

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6️⃣ 5. Merck KGaA (Sigma-Aldrich)

Headquarters: Darmstadt, Germany
Key Offering: Industrial Trehalase, Lab-Grade Enzymes

Merck KGaA, through its Sigma-Aldrich division, provides a comprehensive range of enzymes, including trehalase, for research, diagnostics, and industrial uses. The company supports applications from basic science to large-scale food additive production, emphasizing purity and consistency.

Innovation Initiatives:

• Enhancement of enzyme purity standards for pharmaceutical compliance

• Global R&D efforts in trehalose stabilization for vaccine development

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5️⃣ 6. Thermo Fisher Scientific

Headquarters: Waltham, Massachusetts, USA
Key Offering: Trehalase for Bioprocessing, Cell Therapy

Thermo Fisher Scientific leads in life sciences tools, offering trehalase as part of its enzyme portfolio for biomanufacturing and cryopreservation. Their solutions help protect sensitive biologics, making them essential for advancing therapies in regenerative medicine and biotech.

Innovation Initiatives:

• Optimization of trehalase for use in mRNA and protein stabilization

• Scaling production for food and pharma hybrid applications

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4️⃣ 7. Abcam

Headquarters: Cambridge, United Kingdom
Key Offering: Research Trehalase Antibodies and Enzymes

Abcam specializes in research reagents, providing trehalase enzymes and related antibodies for immunological and biochemical assays. The company facilitates breakthroughs in understanding trehalose metabolism, supporting academic and industrial research in nutrition and health sciences.

Innovation Initiatives:

• Development of multiplex assays incorporating trehalase detection

• Collaborative projects on enzyme inhibitors for therapeutic targets

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3️⃣ 8. Novozymes A/S

Headquarters: Bagsværd, Denmark
Key Offering: Industrial Enzymes Including Trehalase Variants

Novozymes is a pioneer in industrial biotechnology, producing enzymes like trehalase for food processing and biofuel applications. Their expertise in microbial fermentation ensures high-yield, eco-friendly production methods that align with global sustainability goals.

Innovation Initiatives:

• Bioengineering trehalase for improved activity in harsh conditions

• Partnerships with food companies for natural preservative solutions

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2️⃣ 9. DuPont de Nemours

Headquarters: Wilmington, Delaware, USA
Key Offering: Trehalase in Nutrition and Health Ingredients

DuPont, via its nutrition and biosciences segment, incorporates trehalase into ingredient solutions for food fortification and pharmaceutical excipients. The company’s focus on health-driven innovation positions it as a key supplier for functional foods and drug delivery systems.

Innovation Initiatives:

• Research into trehalase-enhanced probiotics for gut health

• Expansion of enzyme portfolios for clean-label food products

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1️⃣ 10. BASF SE

Headquarters: Ludwigshafen, Germany
Key Offering: Trehalase for Agrochemical and Pharma Applications

BASF offers trehalase as part of its chemical and biological portfolio, targeting stabilization in agriculture, food, and medicine. With a strong emphasis on integrated solutions, they support diverse sectors by providing versatile enzymes that enhance product efficacy and stability.

Innovation Initiatives:

• Development of trehalase-based protectants for crop and drug preservation

• Strategic alliances for enzyme commercialization in emerging markets

Read Full Report: Trehalase Market – View in Detailed Research Report

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🌍 Outlook: The Future of the Trehalase Market Is Innovative and Expanding

The trehalase market is experiencing a robust transformation. Although traditional enzyme uses in research dominate currently, the sector is channeling significant resources into advanced applications, biotechnological enhancements, and expanded distribution for food and healthcare needs. This shift reflects broader trends toward natural, protective ingredients that meet consumer demands for health and sustainability.

📈 Key Trends Shaping the Market:

• Growing adoption of food grade trehalase in clean-label products across Europe and Asia

• Regulatory advancements supporting pharmaceutical grade enzymes for drug stabilization by 2029

• Digital tools for enzyme analytics and supply chain optimization

• Industry collaborations to explore trehalase in novel therapies and nutraceuticals

Read Full Report: Trehalase Market – View in Detailed Research Report

The companies highlighted are not only enabling key applications—they’re leading the innovative expansion in biotechnology and nutrition.