The Global 1,1-Cyclobutanedicarboxylic Acid Market (CAS 5445-51-2) was valued at US$ 36.8 Million in 2024 and is projected to reach US$ 52.1 Million by 2029, growing at a Compound Annual Growth Rate (CAGR) of 5.8% during the forecast period. This growth is primarily driven by increasing demand for anticancer drug intermediates, particularly platinum-based chemotherapy medications like carboplatin and cisplatin that utilize 1,1-cyclobutanedicarboxylic acid as a key precursor.

As pharmaceutical formulations become more advanced and global cancer treatment needs escalate, manufacturers are investing heavily in production capacity and process optimization for this specialty chemical. This analysis profiles the Top 10 Companies in the 1,1-Cyclobutanedicarboxylic Acid Market—a mix of established API producers and emerging chemical innovators driving pharmaceutical solutions.

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1,1-Cyclobutanedicarboxylic Acid Market – View in Detailed Research Report

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🔟 1. Zhejiang Taizhou Huangyan Goss Pharm. Chem.

Headquarters: Taizhou, Zhejiang, China
Key Offering: 98% and 99% purity grades

As China’s leading producer of pharmaceutical intermediates, this company supplies high-purity 1,1-cyclobutanedicarboxylic acid to global drug manufacturers. Their vertically integrated production ensures competitive pricing and reliable supply.

Operational Highlights:

• GMP-certified manufacturing facilities
• Annual production capacity of 60+ metric tons
• Strict quality control meeting USP/EP/JP standards

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9️⃣ 2. Anstar New Material

Headquarters: Shanghai, China
Key Offering: Pharmaceutical and reagent grades

Specializing in high-performance chemicals, Anstar has developed proprietary synthesis methods yielding superior purity 1,1-cyclobutanedicarboxylic acid with minimal impurities.

Technical Advantages:

• Patented crystallization technology
• Batch-to-batch consistency
• Strong R&D collaboration network

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8️⃣ 3. Hubei Aoks Bio-Tech

Headquarters: Wuhan, China
Key Offering: API-grade material

This pharmaceutical ingredients specialist supplies 1,1-cyclobutanedicarboxylic acid to major generic drug manufacturers worldwide, with rigorous quality systems supporting regulatory submissions.

Quality Certifications:

• ISO 9001:2015 certified
• FDA-inspected facilities
• EDMF/DMF documentation available

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1,1-Cyclobutanedicarboxylic Acid Market – View in Detailed Research Report

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7️⃣ 4. Minakem

Headquarters: Beuvry-la-Forêt, France
Key Offering: High-purity API intermediate

As a European CDMO leader, Minakem provides GMP-manufactured 1,1-cyclobutanedicarboxylic acid with full regulatory support for oncology drug development.

Regulatory Capabilities:

• Full CMC package development
• EMA/FDA compliance
• Clinical to commercial scale-up

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6️⃣ 5. Nanjing Winsome Chemical

Headquarters: Nanjing, China
Key Offering: Custom purity specifications

This chemical manufacturer has implemented continuous process improvements to enhance yield and reduce production costs while maintaining pharmaceutical-grade quality.

Production Innovations:

• Continuous flow chemistry adoption
• Waste minimization programs
• Energy-efficient operations

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5️⃣ 6. Capot Chemical

Headquarters: Hangzhou, China
Key Offering: Technical and pharmaceutical grades

Capot Chemical has emerged as a reliable supplier of 1,1-cyclobutanedicarboxylic acid, with expanding capacity to meet growing API manufacturing demand.

Market Position:

• Strategic Asia-Pacific distribution
• Competitive pricing structure
• Custom packaging solutions

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4️⃣ 7. Henan Allgreen Chemical

Headquarters: Zhengzhou, China
Key Offering: Bulk quantities

Focused on large-scale chemical production, this company serves both pharmaceutical and industrial applications through cost-effective manufacturing.

Scalability Features:

• Multi-ton production runs
• Dedicated intermediates facility
• Just-in-time inventory management

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1,1-Cyclobutanedicarboxylic Acid Market – View in Detailed Research Report

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3️⃣ 8. Veeprho Pharmaceuticals

Headquarters: Ontario, Canada
Key Offering: cGMP material

This North American supplier specializes in high-quality pharmaceutical intermediates with documentation supporting regulatory filings.

Quality Systems:

• FDA-compliant quality management
• Strict change control procedures
• Comprehensive analytical testing

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2️⃣ 9. ChemScence

Headquarters: Wuhan, China
Key Offering: Research quantities

Supporting early-stage drug development, ChemScence provides small batch quantities with rapid turnaround for preclinical research.

Service Advantages:

• Fast custom synthesis
• Milligram to kilogram quantities
• Technical data package included

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1️⃣ 10. Varsal Chemicals

Headquarters: Plymouth Meeting, USA
Key Offering: High-purity standard

This U.S.-based supplier focuses on providing consistent quality material to North American pharmaceutical manufacturers.

Supply Chain Benefits:

• Domestic US manufacturing
• Reduced lead times
• Flexible logistics solutions

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1,1-Cyclobutanedicarboxylic Acid Market – View in Detailed Research Report

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🔍 Market Outlook: Evolving Pharmaceutical Demand Shapes Future Growth

The 1,1-cyclobutanedicarboxylic acid market is experiencing transformation as oncology treatment paradigms evolve and generic drug production expands globally.

📈 Critical Market Trends:

• Increasing carboplatin/cisplatin production in emerging markets
• Stricter regulatory requirements for impurity profiles
• Growing preference for GMP-certified suppliers
• Vertical integration trends among API manufacturers

Get Full Report Here:
1,1-Cyclobutanedicarboxylic Acid Market – View in Detailed Research Report

The featured companies are not just suppliers—they’re enablers of critical cancer treatments through their expertise in this essential pharmaceutical intermediate.