The Global HBTU (CAS 94790-37-1) Market was valued at USD 48.7 Million in 2023 and is projected to reach USD 68.3 Million by 2029, growing at a Compound Annual Growth Rate (CAGR) of 5.8% during the forecast period (2024–2029). This growth is driven by increasing demand for peptide therapeutics, expansion of biopharmaceutical research, and widespread adoption of solid-phase peptide synthesis techniques across academic and commercial laboratories.

As the pharmaceutical industry increasingly turns to peptide-based drugs for targeted therapies, the critical role of high-purity coupling reagents like HBTU in peptide synthesis has become paramount. This specialized market is dominated by chemical manufacturers that maintain pharmaceutical-grade production standards. Below we examine the Top 10 Companies in the HBTU Industry—from established peptide synthesis specialists to emerging biotechnology suppliers shaping this critical pharmaceutical supply chain.

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🔟 1. Norna Group

Headquarters: Xi’an, China
Key Offering: HBTU (99% purity), cGMP peptide synthesis reagents

Norna Group has positioned itself as China’s premier manufacturer of peptide coupling agents, supplying pharmaceutical companies worldwide with high-purity HBTU and related compounds. Their vertically integrated production facility ensures consistent quality for peptide drug manufacturers.

Product Advantages:

• Pharmaceutical-grade HBTU with 98-99.5% purity options

• Strict compliance with current Good Manufacturing Practices

• Custom formulation services for specialized peptide synthesis

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Global HBTU (CAS 94790-37-1) Market – View in Detailed Research Report

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9️⃣ 2. BioDee BioTech

Headquarters: Shanghai, China
Key Offering: Ultra-pure HBTU (≥99.9%), complete peptide reagent kits

Specializing in amino acid derivatives and coupling reagents, BioDee operates one of Asia’s most advanced HBTU production facilities. Their products are widely adopted by research institutions and pharmaceutical development companies.

Product Advantages:

• Industry-leading purity levels through proprietary purification

• Rigorous quality control including NMR and mass spec validation

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8️⃣ 3. Shanghai Medpep

Headquarters: Shanghai, China
Key Offering: Research and pharmaceutical-grade HBTU formulations

As both manufacturer and research end-user, Shanghai Medpep provides unique technical expertise in HBTU applications. The company serves over 500 biotechnology clients globally with cGMP-compliant materials.

Product Advantages:

• Annual production capacity exceeding 20 metric tons

• Full analytical documentation for regulatory submissions

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7️⃣ 4. NJPeptide

Headquarters: Nanjing, China
Key Offering: HBTU solutions, protected amino acids, peptide synthesis reagents

NJPeptide has built a strong reputation for consistency in peptide synthesis chemicals, serving pharmaceutical manufacturers and academic researchers across North America and Europe.

Product Advantages:

• Rigorous batch-to-batch consistency verified by independent labs

• Competitive pricing structure for various order volumes

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Global HBTU (CAS 94790-37-1) Market – View in Detailed Research Report

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6️⃣ 5. HighFine Biotech

Headquarters: Suzhou, China
Key Offering: High-purity HBTU powder, custom formulations

HighFine specializes in pharmaceutical-grade peptide synthesis reagents, employing patented crystallization technology to produce exceptionally pure HBTU for sensitive applications.

Product Advantages:

• Moisture content consistently below 0.5%

• Shelf life exceeding 24 months under proper conditions

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5️⃣ 6. Haihang Industry

Headquarters: Jinan, China
Key Offering: Industrial and pharmaceutical-grade HBTU

With extensive experience in fine chemical manufacturing, Haihang provides HBTU to large-scale peptide producers and research institutions worldwide through multiple API production sites.

Product Advantages:

• Bulk production capabilities for industrial orders

• Flexible packaging from lab-scale to commercial quantities

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4️⃣ 7. GL Biochem

Headquarters: Shanghai, China
Key Offering: Ultra-pure HBTU, comprehensive peptide synthesis solutions

A pioneer in China’s peptide industry, GL Biochem manufactures HBTU alongside a complete portfolio of peptide synthesis materials used in therapeutic development.

Product Advantages:

• Multiple certifications including USP and EP standards

• Dedicated research facility for peptide reagent innovation

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3️⃣ 8. ChemPep Inc.

Headquarters: Wellington, Florida, USA
Key Offering: Research-grade HBTU and specialty chemicals

This U.S.-based supplier focuses on high-purity HBTU primarily for pharmaceutical research applications, serving academic institutions and biotech companies.

Product Advantages:

• Rapid delivery to North American research facilities

• Technical support for peptide synthesis optimization

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2️⃣ 9. Bachem AG

Headquarters: Bubendorf, Switzerland
Key Offering: cGMP HBTU for pharmaceutical applications

While primarily known for finished peptides, Bachem also produces high-quality coupling reagents for internal use and select pharmaceutical clients.

Product Advantages:

• Pharmaceutical production standards and documentation

• Integration with complete peptide manufacturing systems

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1️⃣ 10. Iris Biotech GmbH

Headquarters: Marktredwitz, Germany
Key Offering: Premium HBTU, specialized peptide synthesis kits

This German biotechnology company supplies high-quality peptide reagents to European pharmaceutical manufacturers, with comprehensive quality systems governing production.

Product Advantages:

• Compliance with REACH and TSCA regulations

• Extensive technical documentation and support

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Global HBTU (CAS 94790-37-1) Market – View in Detailed Research Report

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🧪 Outlook: The Future of HBTU in Pharmaceutical Synthesis

The HBTU market is projected to exceed $95 million by 2030, driven by accelerating peptide therapeutic development and increasing automation in synthesis processes. While Chinese manufacturers currently lead in production capacity, innovation in greener synthesis methods may reshape the competitive landscape.

📈 Key Market Trends:

• Growing demand for ≥99% purity HBTU in regulated manufacturing

• Increasing automation requiring standardized reagent properties

• Tightening regulatory standards for peptide drug impurities

• Emerging technologies for more sustainable coupling methods

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Global HBTU (CAS 94790-37-1) Market – View in Detailed Research Report

These industry leaders are not merely supplying chemicals—they’re enabling the next generation of peptide-based therapeutics that will revolutionize medicine.