The Global Oxaloacetic Acid Market was valued at US$ 123 Million in 2024 and is projected to reach US$ 173 Million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 4.8% during the forecast period (2025-2032). This growth is fueled by expanding applications in pharmaceutical formulations, biotechnological research, and industrial biochemistry where this key Krebs cycle intermediate plays vital metabolic roles.
As scientific understanding of cellular metabolism deepens and demand for specialty biochemicals rises, oxaloacetic acid has emerged as a critical compound with therapeutic and industrial potential. This analysis profiles the Top 10 Companies in the Oxaloacetic Acid Market – a combination of established chemical manufacturers, biotech specialists, and research-focused organizations driving innovation in this specialized sector.
🔟 1. Showa Denko K.K.
Headquarters: Tokyo, Japan
Key Offering: Pharmaceutical Grade Oxaloacetic Acid (≥98% purity)
A leader in fine chemical production, Showa Denko manufactures high-purity oxaloacetic acid through proprietary enzymatic processes. The company supplies global pharmaceutical companies and research institutions, with quality systems meeting stringent pharmacopeia standards.
Technical Capabilities:
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Continuous fermentation technology for enhanced yield
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Stable crystalline forms for improved shelf life
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Customized packaging for lab and industrial use
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9️⃣ 2. Hangzhou Hairui Chemical Co., Ltd.
Headquarters: Hangzhou, China
Key Offering: Industrial and Research Grade Oxaloacetic Acid
This Chinese chemical specialist has become a primary supplier of oxaloacetic acid to global markets, offering products with purity levels from 95% to 99% to meet diverse application requirements across industries.
Technical Capabilities:
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Multi-ton scale production capacity
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Strict impurity profile control
8️⃣ 3. Shanghai Yuhan Chemical Co., Ltd.
Headquarters: Shanghai, China
Key Offering: Oxaloacetic Acid and Salts
Yuhan Chemical specializes in oxaloacetate compounds for pharmaceutical intermediates and research applications, with advanced analytical capabilities ensuring batch-to-batch consistency in their products.
Technical Capabilities:
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Metal salt derivatives for enhanced stability
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GMP-compliant manufacturing processes
7️⃣ 4. Guangzhou Dreampharm Biotechnology
Headquarters: Guangzhou, China
Key Offering: Ultra-High Purity Research Reagents
Dreampharm focuses on biochemical research applications, providing meticulously characterized oxaloacetic acid for metabolic studies, enzyme research, and cell culture applications.
Technical Capabilities:
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Isotope-labeled compounds for tracer studies
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Cell culture tested formulations
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6️⃣ 5. TCI Chemicals
Headquarters: Tokyo, Japan
Key Offering: Analytical Grade Standards
TCI provides high-purity oxaloacetic acid certified reference materials to analytical laboratories worldwide, with comprehensive documentation supporting research and quality control applications.
Technical Capabilities:
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Advanced analytical characterizations
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Strict stability testing protocols
5️⃣ 6. Sigma-Aldrich (Merck KGaA)
Headquarters: Darmstadt, Germany
Key Offering: Research Biochemicals
As part of the Merck Group, Sigma-Aldrich supplies rigorously tested oxaloacetic acid to academic and industrial research laboratories globally, supporting cutting-edge metabolic research.
Technical Capabilities:
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Comprehensive certificate of analysis
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Global logistics network
4️⃣ 7. Alfa Aesar (Thermo Fisher Scientific)
Headquarters: Lancashire, UK
Key Offering: Specialty Chemicals
Alfa Aesar provides oxaloacetic acid for formulation development and process chemistry applications, leveraging Thermo Fisher’s global distribution capabilities.
Technical Capabilities:
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Multiple purity grades available
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Technical support services
3️⃣ 8. Spectrum Chemical
Headquarters: Gardena, California, USA
Key Offering: USP/FCC Compliant Materials
Spectrum Chemical manufactures oxaloacetic acid meeting stringent regulatory standards for pharmaceutical and food industry applications.
Technical Capabilities:
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Regulatory documentation support
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Industrial-scale supply capabilities
Download FREE Sample Report: Oxaloacetic Acid Market – View in Detailed Research Report
2️⃣ 9. Biosynth Carbosynth
Headquarters: Staad, Switzerland
Key Offering: Custom Derivatives
This Swiss firm specializes in modified oxaloacetate compounds for specialized research and pharmaceutical development applications.
Technical Capabilities:
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Structure-activity relationship studies
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Radiolabeled synthesis
1️⃣ 10. Medical Isotopes, Inc.
Headquarters: Pelham, New Hampshire, USA
Key Offering: Clinical Grade Materials
Specializing in biochemicals for medical applications, this company produces ultra-pure oxaloacetic acid formulations meeting exacting standards for therapeutic development.
Technical Capabilities:
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GMP manufacturing facilities
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Therapeutic formulation expertise
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