The Global Pharmaceutical Grade Crotonic Acid Market was valued at USD 58.7 Million in 2024 and is projected to reach USD 82.4 Million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 4.3% during the forecast period (2024–2032). This expansion is fueled by rising pharmaceutical manufacturing activity, increasing demand for high-purity excipients, and advancements in polymer-based drug delivery systems requiring crotonic acid as a key component.
With pharmaceutical companies prioritizing supply chain reliability and regulatory compliance, attention focuses on the leading producers maintaining stringent quality standards. This analysis examines the Top 10 Pharmaceutical Grade Crotonic Acid Manufacturers establishing benchmarks for purity and supply chain excellence.
🔟 1. Tianjin Jinhui Pharmaceutical Group
Headquarters: Tianjin, China
Key Offering: USP/EP Grade Crotonic Acid (99.8%+ purity)
Tianjin Jinhui has emerged as China’s premier pharmaceutical intermediate supplier, with dedicated crotonic acid production lines serving multinational drug manufacturers. The company exports to over 30 countries with specialized packaging for hygroscopic materials.
Regulatory Compliance:
- FDA-registered manufacturing facility
- EDQM CEP certification for European markets
- Annual stability testing protocols
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9️⃣ 2. Zhengzhou Tuozhixiang Trading
Headquarters: Zhengzhou, China
Key Offering: Pharmaceutical Intermediates (99.5-99.8% purity grades)
Specializing in API and excipient distribution, Zhengzhou Tuozhixiang has built flexible supply chains serving second-tier pharmaceutical manufacturers across emerging markets.
Market Advantages:
- Multilingual technical support team
- Just-in-time inventory systems
- Competitive MOQ policies
8️⃣ 3. Chem of China
Headquarters: Shanghai, China
Key Offering: GMP-certified Crotonic Acid batches
This chemical conglomerate operates Asia’s largest integrated crotonic acid production complex, with dedicated pharmaceutical-grade purification units meeting various pharmacopeia standards.
Production Capacity:
- 8,000 metric tons annual output
- On-site analytical laboratories
- ISO 13485 certified quality systems
7️⃣ 4. XIAN Kono Chem
Headquarters: Xi’an, China
Key Offering: Ultra-Low Particulate Grades
XIAN Kono specializes in niche pharmaceutical chemicals, producing crotonic acid with controlled particle size distributions for direct compression tablet formulations.
Technical Specifications:
- USP-NF monograph compliance
- Heavy metals <5 ppm
- Residual solvent monitoring
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6️⃣ 5. Huixin Chemical
Headquarters: Shandong, China
Key Offering: Dual-Use Industrial/Pharma Grades
Huixin’s flexible production model allows rapid switching between pharmaceutical and industrial-grade crotonic acid, serving diverse customer needs from single pharmaceutical plants to large chemical distributors.
Facility Upgrades:
- New crystallization purification unit (2023)
- Automated packaging lines
- Expanded cold chain storage
5️⃣ 6. Godavari Biorefineries
Headquarters: Mumbai, India
Key Offering: Bio-Based Derivatives
Godavari’s innovative fermentation-based production method offers pharmaceutical companies sustainable sourcing options for crotonic acid, with 30% lower carbon footprint versus petrochemical routes.
Sustainability Metrics:
- 90% renewable energy usage
- Zero liquid discharge facility
- GMP-EC certified operations
4️⃣ 7. BIO-TECH
Headquarters: Seoul, South Korea
Key Offering: Injectable-Grade Materials
Specializing in high-purity excipients, BIO-TECH produces crotonic acid meeting stringent endotoxin requirements for parenteral drug formulations.
Quality Benchmarking:
- USP <85> and <161> compliance
- Class 10000 cleanrooms
- DNA/RNA-free certification
3️⃣ 8. Otto Chemie
Headquarters: Mumbai, India
Key Offering: Formulation-Ready Grades
Otto Chemie provides crotonic acid pre-blended with common pharmaceutical carriers, reducing processing time for generic drug manufacturers.
Value-Added Services:
- Custom particle engineering
- Excipient compatibility studies
- Regulatory documentation support
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2️⃣ 9. Weylchem
Headquarters: Frankfurt, Germany
Key Offering: EP Compliance Packages
Weylchem’s European manufacturing base provides localized supply of crotonic acid with full EP compliance documentation for EU-based pharmaceutical customers.
Regulatory Support:
- EDMF/ASMF preparation
- Impurity profiling services
- QbD-based process validation
1️⃣ 10. Shanghai Yayu Biological Technology
Headquarters: Shanghai, China
Key Offering: Modified Release Grades
Shanghai Yayu develops specialized crotonic acid formulations for controlled-release drug delivery systems, with proprietary coating technologies for pH-dependent release profiles.
Technical Capabilities:
- In-vitro dissolution testing
- Formulation patent support
- Pilot-scale batch services
Get Full Report Here: https://www.24chemicalresearch.com/reports/295991/global-pharmaceutical-grade-crotonic-acid-forecast-market-2025-2032-492
🌍 Market Outlook: Pharmaceutical Crotonic Acid Evolution
The pharmaceutical crotonic acid landscape is transforming with regulatory changes and advanced drug delivery requirements. Manufacturers must adapt to increasing quality expectations while maintaining cost competitiveness in a supply-constrained environment.
📈 Critical Industry Trends:
- Tighter control of mutagenic impurities per ICH M7
- Growing preference for bio-based production methods
- Increasing audits of Chinese API facilities by Western regulators
- Demand surge for controlled-release formulation components
Get Full Report Here: https://www.24chemicalresearch.com/reports/295991/global-pharmaceutical-grade-crotonic-acid-forecast-market-2025-2032-492
The profiled companies represent the vanguard of pharmaceutical crotonic acid production, combining technical expertise with global supply capabilities to meet the pharmaceutical industry’s exacting requirements.
