The Global Mixed-Mode Chromatography Resin Market was valued at USD 147 million in 2023 and is projected to reach USD 196.89 million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 3.30% during the forecast period (2024-2032). This steady expansion reflects the critical role these resins play in biopharmaceutical manufacturing, where they enable complex purification processes through combined ionic, hydrophobic and hydrogen bonding interactions.

As biomanufacturers demand more efficient separation solutions for monoclonal antibodies, vaccines and novel biologics, mixed-mode chromatography has emerged as a versatile tool for capture, intermediate purification and polishing steps. Here we profile the Top 10 Companies in the Mixed-Mode Chromatography Resin Industry—technology pioneers advancing purification science for next-generation therapies.

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🔟 1. Danaher Corporation (Pall Biotech)

Headquarters: Washington, D.C., USA
Key Offering: Mustang Q XT, HEA HyperCel resins

Danaher’s life sciences segment, featuring Pall Biotech solutions, leads in multimodal chromatography technologies for large-scale bioprocessing. Their resins combine multiple interaction modes to address challenging separation requirements.

Technology Highlights:

• High-capacity ligands for mAb purification
• Platforms supporting continuous processing
• Validated for CGMP manufacturing

Download FREE Sample Report: Global Mixed-Mode Chromatography Resin Market – View in Detailed Research Report

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9️⃣ 2. Cytiva (formerly GE Healthcare)

Headquarters: Marlborough, Massachusetts, USA
Key Offering: Capto MMC, Capto adhere resins

Cytiva’s multimodal chromatography media portfolio builds on decades of separation science expertise, offering solutions optimized for antibody purification and viral clearance applications.

Technology Highlights:

• Combined ion exchange and hydrophobic interactions
• High-flow agarose base matrices
• Process-scale ready formats

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8️⃣ 3. Bio-Rad Laboratories

Headquarters: Hercules, California, USA
Key Offering: CHT Ceramic Hydroxyapatite, Nuvia resins

Bio-Rad provides innovative mixed-mode solutions including ceramic hydroxyapatite media that combine cation exchange with calcium metal affinity interactions.

Technology Highlights:

• Stable mechanical properties
• Broad pH operating range (4-14)
• High-resolution separation capabilities

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7️⃣ 4. Tosoh Bioscience

Headquarters: Tokyo, Japan
Key Offering: TOYOPEARL MX-Trp-650M resin

Tosoh’s mixed-mode resins feature proprietary ligand chemistries designed for challenging monoclonal antibody and recombinant protein purifications.

Technology Highlights:

• Tryptophan-functionalized ligands
• High chemical stability
• Multiple particle size options

Download FREE Sample Report: Global Mixed-Mode Chromatography Resin Market – View in Detailed Research Report

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6️⃣ 5. Merck Millipore

Headquarters: Darmstadt, Germany
Key Offering: Eshmuno HCX, ProSep resins

Merck’s Life Science business offers mixed-mode chromatography solutions through its Eshmuno and ProSep product lines for industrial-scale bioprocessing.

Technology Highlights:

• High-capacity cation exchange resins
• Robust validation support packages
• GMP manufacturing compliance

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5️⃣ 6. Agilent Technologies

Headquarters: Santa Clara, California, USA
Key Offering: AdvanceBio mixed-mode columns

Agilent provides analytical-scale mixed-mode columns that combine reversed-phase and ion exchange mechanisms for challenging biomolecule separations.

Technology Highlights:

• Optimized for LC/MS applications
• Enhanced selectivity for complex samples
• 2.7μm core-shell particle technology

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4️⃣ 7. Thermo Fisher Scientific

Headquarters: Waltham, Massachusetts, USA
Key Offering: ProPac mixed-mode columns

Thermo Fisher’s chromatography solutions include mixed-mode columns designed for quality control and analytical applications in biopharmaceutical development.

Technology Highlights:

• Combined weak anion exchange functionality
• High temperature stability (to 90°C)
• Consistent column-to-column performance

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3️⃣ 8. Repligen Corporation

Headquarters: Waltham, Massachusetts, USA
Key Offering: OPUS mixed-mode chromatography columns

Repligen develops process-scale chromatography solutions including mixed-mode technologies tailored for biopharmaceutical manufacturing.

Technology Highlights:

• Pre-packed column formats
• Validated for CGMP operations
• Custom ligand development capabilities

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2️⃣ 9. Purolite Life Sciences

Headquarters: King of Prussia, Pennsylvania, USA
Key Offering: HyperCel STAR and Prime resins

Purolite offers mixed-mode chromatography media designed to address challenging purification requirements in biopharmaceutical production.

Technology Highlights:

• Hydrophobic charge induction technology
• High binding capacity (>50 g/L)
• Broad pH stability (2-12)

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1️⃣ 10. JSR Life Sciences

Headquarters: Tokyo, Japan
Key Offering: TOYOPEARL MX-Trp resin series

JSR Life Sciences develops specialty mixed-mode chromatography resins optimized for monoclonal antibody purification processes.

Technology Highlights:

• Tryptophan ligand chemistry
• High flow rate processing
• Excellent chemical resistance

Get Full Report Here: Global Mixed-Mode Chromatography Resin Market – View in Detailed Research Report

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🔬 Market Outlook: The Evolving Landscape of Chromatography Purification

The mixed-mode chromatography resin market continues to develop as biopharmaceutical manufacturers seek solutions that combine the benefits of multiple separation mechanisms in a single step. This technology plays an increasingly important role in the purification of complex biologics, vaccines and cell/gene therapies.

📈 Key Market Trends:

• Growing adoption in biosimilar manufacturing
• Development of novel ligand chemistries
• Integration with continuous bioprocessing platforms
• Expansion into mRNA therapeutic purification
• Increasing focus on resin lifetime and cost efficiency

Get Full Report Here: Global Mixed-Mode Chromatography Resin Market – View in Detailed Research Report

The companies profiled above represent the industry leaders driving innovation in mixed-mode chromatography technology, enabling more efficient and cost-effective purification of next-generation biotherapeutics.