The Global Trehalose Market was valued at USD 180.6 Million in 2024 and is projected to reach USD 228.1 Million by 2030, growing at a Compound Annual Growth Rate (CAGR) of 3.4% during the forecast period (2024–2030). This growth stems from increasing demand in food preservation, pharmaceutical stabilization, and cosmetic formulations where trehalose’s unique biochemical properties enhance product performance and shelf life.

As industries shift toward natural stabilizers and cryoprotectants, trehalose has emerged as a versatile disaccharide with applications spanning multiple sectors. This blog profiles the Top 10 Companies in the Trehalose Industry—from pioneering biotech firms to diversified chemical conglomerates—that are driving advancements and capacity expansions globally.

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🔟 1. Hayashibara Co., Ltd.

Headquarters: Okayama, Japan
Key Offering: USP/JP grade trehalose

A Nagase Group company, Hayashibara developed the first commercial enzymatic trehalose production process. The company maintains 40% global market share through continuous optimization of its proprietary maltooligosyl trehalose synthase technology.

Technological Leadership:

• Originated modern trehalose production methods in 1995
• Supplies 80% of Japan’s pharmaceutical-grade trehalose
• Certified Kosher/Halal production facilities

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Trehalose Market – View in Detailed Research Report

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9️⃣ 2. Meihua Holdings Group Co., Ltd.

Headquarters: Hebei, China
Key Offering: Industrial-grade trehalose

China’s largest trehalose manufacturer utilizes advanced fermentation technology to achieve economies of scale. Meihua’s vertical integration from corn starch to finished product enables competitive pricing for bulk buyers.

Production Scale:

• 40,000 MT annual capacity across 3 facilities
• 60% domestic market penetration in China
• Strategic pricing 15-20% below Japanese competitors

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8️⃣ 3. Sinozyme Biotechnology Co., Ltd.

Headquarters: Jiangsu, China
Key Offering: High-purity enzyme-derived trehalose

Sinozyme specializes in biocatalysis processes for premium-grade trehalose used in injectable pharmaceuticals. Their immobilized enzyme technology achieves 92% conversion efficiency—industry-leading for non-GMO production.

Quality Benchmarks:

• Meets EP 9.0/USP-NF standards
• Endotoxin levels <0.25 EU/mg
• Validated microbial control systems

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7️⃣ 4. Lianmeng Chemical Group

Headquarters: Shandong, China
Key Offering: Cost-effective trehalose solutions

This chemical producer focuses on mid-purity trehalose for food processing and industrial applications. Their continuous production system achieves 30% higher throughput than batch processing alternatives.

Operational Advantages:

• 25,000 MT annual throughput capacity
• 98.5% minimum purity for food applications
• Dedicated export facility with 15,000 MT/year capacity

Download FREE Sample Report:
Trehalose Market – View in Detailed Research Report

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6️⃣ 5. Shandong Fuyang Biotechnology Co., Ltd.

Headquarters: Shandong, China
Key Offering: Fermented trehalose specialties

Fuyang’s patented strain engineering delivers trehalose with customized molecular profiles for cosmetic emulsifiers and nutraceutical carriers. Their R&D pipeline includes trehalose-fatty acid conjugates for enhanced bioavailability.

Application Innovations:

• Moisture retention grades for skincare
• Thermostable formulations for baked goods
• Co-processed excipients for ODT medications

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5️⃣ 6. Cargill, Incorporated

Headquarters: Minnesota, USA
Key Offering: Food-system trehalose solutions

Cargill integrates trehalose into its sweetener and texturant portfolios for multinational food manufacturers. Their technical service teams assist with reformulation projects to replace less functional sugars.

Market Access:

• Regional warehouses in North America, Europe, Asia
• JIT delivery for Fortune 500 food processors
• FSSC 22000 certified facilities

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4️⃣ 7. BASF SE

Headquarters: Ludwigshafen, Germany
Key Offering: Pharma-grade trehalose

BASF supplies cGMP trehalose as a lyoprotectant for biologic drugs and vaccines. Their quality management system supports regulatory filings in all major markets with full documentation support.

Regulatory Compliance:

• EDMF/CEPs available for regulatory submissions
• ISO 15378 certified packaging
• ICH stability data packages

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3️⃣ 8. Merck KGaA

Headquarters: Darmstadt, Germany
Key Offering: Research-grade trehalose

Merck’s Life Science division provides ultra-pure trehalose for cell culture media and diagnostic applications. Each batch includes comprehensive analytical documentation for critical research uses.

Scientific Support:

• HPLC chromatograms with each batch
• NMR confirmation of structure
• Endotoxin testing for cell culture

Download FREE Sample Report:
Trehalose Market – View in Detailed Research Report

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2️⃣ 9. DSM Nutritional Products

Headquarters: Heerlen, Netherlands
Key Offering: Stabilized nutrient systems

DSM incorporates trehalose into vitamin premixes and sensitive bioactive compounds. Their proprietary blending technology prevents moisture migration in humid climates.

Formulation Expertise:

• 12-month shelf life validation data
• Customized particle engineering
• Compatibility testing with actives

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1️⃣ 10. CJ CheilJedang Corporation

Headquarters: Seoul, South Korea
Key Offering: Fermented functional ingredients

CJ’s biotechnology division produces trehalose through strain-optimized fermentation for the Asian functional food market. Their co-processing techniques enhance solubility and mixing characteristics.

Regional Specialization:

• Preferred supplier to Korean health brands
• Customized blends for beverage applications
• Clean-label certification programs

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🌍 Market Evolution: Trehalose’s Cross-Industry Impact

The trehalose market is transitioning from specialty applications to mainstream adoption across multiple verticals. Asia continues to dominate production, but new manufacturing technologies are enabling global supply chain diversification.

📈 Critical Development Areas:

• Precision fermentation for pharmaceutical applications
• Next-gen stabilization in mRNA therapeutics
• Clean-label reformulation in processed foods
• High-value cosmetic preservation systems

Read Full Report:
Trehalose Market – View in Detailed Research Report

The profiled companies represent the technological and commercial vanguard transforming trehalose from a niche specialty to an essential industrial biomaterial.